Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy

dimethylallyl diphosphate:4-hydroxyphenylpyruvate 3-dimethylallyltransferase

dimethylallyl diphosphate + 4-hydroxyphenylpyruvate = diphosphate + 3-dimethylallyl-4-hydroxyphenylpyruvate [RN:R06757]

R06757
Reaction

dimethylallyl diphosphate [CPD:C00235];
4-hydroxyphenylpyruvate [CPD:C01179]

The enzyme is involved in the biosynthesis of the 3-dimethylallyl-4-hydroxyphenylpyruvate moiety of the aminocoumarin antibiotics clorobiocin and novobiocin [1].

EC 2.5.1.111 created 2013

1  [PMID:12618544]

Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L.

CloQ, a prenyltransferase involved in clorobiocin biosynthesis.

Proc Natl Acad Sci U S A 100:2316-21 (2003)
DOI:10.1073/pnas.0337708100

[ag:AAN65239]

2  [PMID:17077503]

Keller S, Pojer F, Heide L, Lawson DM

Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase  CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes.

Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1153-5 (2006)
DOI:10.1107/S1744309106042527

3  [PMID:20946900]

Metzger U, Keller S, Stevenson CE, Heide L, Lawson DM

Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway.

J Mol Biol 404:611-26 (2010)
DOI:10.1016/j.jmb.2010.09.067

[ag:AAN65239]

4  [PMID:19557032]

Ozaki T, Mishima S, Nishiyama M, Kuzuyama T

NovQ is a prenyltransferase capable of catalyzing the addition of a dimethylallyl group to both phenylpropanoids and flavonoids.

J Antibiot (Tokyo) 62:385-92 (2009)
DOI:10.1038/ja.2009.48

[ag:AAF67510]