Entry |
|
Name |
4-hydroxyphenylpyruvate 3-dimethylallyltransferase;
CloQ;
4HPP dimethylallyltransferase;
NovQ
|
Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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Sysname |
dimethylallyl diphosphate:4-hydroxyphenylpyruvate 3-dimethylallyltransferase
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Reaction(IUBMB) |
dimethylallyl diphosphate + 4-hydroxyphenylpyruvate = diphosphate + 3-dimethylallyl-4-hydroxyphenylpyruvate [RN: R06757]
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Reaction(KEGG) |
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Substrate |
dimethylallyl diphosphate [CPD: C00235];
4-hydroxyphenylpyruvate [CPD: C01179]
|
Product |
diphosphate [CPD: C00013];
3-dimethylallyl-4-hydroxyphenylpyruvate [CPD: C12456]
|
Comment |
The enzyme is involved in the biosynthesis of the 3-dimethylallyl-4-hydroxyphenylpyruvate moiety of the aminocoumarin antibiotics clorobiocin and novobiocin [1].
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History |
EC 2.5.1.111 created 2013
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Pathway |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K12707 | 4-hydroxyphenylpyruvate 3-dimethylallyltransferase |
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Genes |
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Reference |
|
Authors |
Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L. |
Title |
CloQ, a prenyltransferase involved in clorobiocin biosynthesis. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Keller S, Pojer F, Heide L, Lawson DM |
Title |
Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes. |
Journal |
|
Reference |
|
Authors |
Metzger U, Keller S, Stevenson CE, Heide L, Lawson DM |
Title |
Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway. |
Journal |
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Sequence |
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Reference |
|
Authors |
Ozaki T, Mishima S, Nishiyama M, Kuzuyama T |
Title |
NovQ is a prenyltransferase capable of catalyzing the addition of a dimethylallyl group to both phenylpropanoids and flavonoids. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.5.1.111 |
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LinkDB |
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