Entry |
|
Name |
norspermine synthase;
long-chain polyamine synthase (ambiguous)
|
Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
|
Sysname |
S-adenosyl 3-(methylsulfanyl)propylamine:norspermidine 3-aminopropyltransferase
|
Reaction(IUBMB) |
S-adenosyl 3-(methylsulfanyl)propylamine + norspermidine = S-methyl-5'-thioadenosine + norspermine [RN: R11088]
|
Reaction(KEGG) |
|
Substrate |
S-adenosyl 3-(methylsulfanyl)propylamine [CPD: C01137];
norspermidine [CPD: C03375]
|
Product |
S-methyl-5'-thioadenosine [CPD: C00170];
norspermine [CPD: C21004]
|
Comment |
The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.127, caldopentamine synthase, this enzyme does not accept norspermine as a substrate.
|
History |
EC 2.5.1.126 created 2014
|
Reference |
|
Authors |
Knott JM |
Title |
Biosynthesis of long-chain polyamines by crenarchaeal polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum. |
Journal |
|
Sequence |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.5.1.126 |
|
LinkDB |
|