| Entry |
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| Name |
norspermine synthase;
long-chain polyamine synthase (ambiguous)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
S-adenosyl 3-(methylsulfanyl)propylamine:norspermidine 3-aminopropyltransferase
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| Reaction(IUBMB) |
S-adenosyl 3-(methylsulfanyl)propylamine + norspermidine = S-methyl-5'-thioadenosine + norspermine [RN: R11088]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl 3-(methylsulfanyl)propylamine [CPD: C01137];
norspermidine [CPD: C03375]
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| Product |
S-methyl-5'-thioadenosine [CPD: C00170];
norspermine [CPD: C21004]
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| Comment |
The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.127, caldopentamine synthase, this enzyme does not accept norspermine as a substrate.
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| History |
EC 2.5.1.126 created 2014
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| Reference |
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| Authors |
Knott JM |
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| Title |
Biosynthesis of long-chain polyamines by crenarchaeal polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.126 |
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| LinkDB |
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