KEGG   ENZYME: 2.5.1.126Help
Entry
EC 2.5.1.126                Enzyme                                 

Name
norspermine synthase;
long-chain polyamine synthase (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl 3-(methylsulfanyl)propylamine:norspermidine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosyl 3-(methylsulfanyl)propylamine + norspermidine = S-methyl-5'-thioadenosine + norspermine [RN:R11088]
Reaction(KEGG)
Substrate
S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
norspermidine [CPD:C03375]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
norspermine [CPD:C21004]
Comment
The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.127, caldopentamine synthase, this enzyme does not accept norspermine as a substrate.
History
EC 2.5.1.126 created 2014
Reference
1  [PMID:19822146]
  Authors
Knott JM
  Title
Biosynthesis of long-chain polyamines by crenarchaeal polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum.
  Journal
FEBS Lett 583:3519-24 (2009)
DOI:10.1016/j.febslet.2009.10.014
  Sequence
[pai:PAE1203]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.126
IUBMB Enzyme Nomenclature: 2.5.1.126
ExPASy - ENZYME nomenclature database: 2.5.1.126
BRENDA, the Enzyme Database: 2.5.1.126
LinkDB All DBs

DBGET integrated database retrieval system