KEGG ENZYME: 2.5.1.126

ENZYME: 2.5.1.126

Entry

EC 2.5.1.126 Enzyme

Name

norspermine synthase;
long-chain polyamine synthase (ambiguous)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

S-adenosyl 3-(methylsulfanyl)propylamine:norspermidine 3-aminopropyltransferase

Reaction(IUBMB)

S-adenosyl 3-(methylsulfanyl)propylamine + norspermidine = S-methyl-5'-thioadenosine + norspermine [RN:R11088]

Reaction(KEGG)

R11088

Substrate

S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
norspermidine [CPD:C03375]

Product

S-methyl-5'-thioadenosine [CPD:C00170];
norspermine [CPD:C21004]

Comment

The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.127, caldopentamine synthase, this enzyme does not accept norspermine as a substrate.

History

EC 2.5.1.126 created 2014

Reference

1 [PMID:19822146]

Authors

Knott JM

Title

Biosynthesis of long-chain polyamines by crenarchaeal polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum.

Journal

FEBS Lett 583:3519-24 (2009)
DOI:10.1016/j.febslet.2009.10.014

Sequence

[pai:PAE1203]