Entry |
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Name |
2-acylphloroglucinol 4-prenyltransferase;
PT-1 (gene name);
PT1L (gene name);
aromatic prenyltransferase (ambiguous)
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Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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Sysname |
dimethylallyl diphosphate:2-acylphloroglucinol 4-dimethylallyltransferase
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Reaction(IUBMB) |
dimethylallyl diphosphate + a 2-acylphloroglucinol = diphosphate + a 2-acyl-4-prenylphloroglucinol [RN: R11609]
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Reaction(KEGG) |
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Substrate |
dimethylallyl diphosphate [CPD: C00235];
2-acylphloroglucinol [CPD: C21498]
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Product |
diphosphate [CPD: C00013];
2-acyl-4-prenylphloroglucinol [CPD: C21499]
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Comment |
The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids. It also acts with much lower activity on naringenin chalcone. Forms a complex with EC 2.5.1.137, 2-acyl-4-prenylphloroglucinol 6-prenyltransferase, which catalyses additional prenylation reactions. Requires Mg2+.
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History |
EC 2.5.1.136 created 2017
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Orthology |
K21590 | 2-acylphloroglucinol 4-prenyltransferase |
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Reference |
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Authors |
Tsurumaru Y, Sasaki K, Miyawaki T, Uto Y, Momma T, Umemoto N, Momose M, Yazaki K |
Title |
HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops. |
Journal |
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Sequence |
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Reference |
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Authors |
Li H, Ban Z, Qin H, Ma L, King AJ, Wang G |
Title |
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.5.1.136 |
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LinkDB |
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