EC 18.104.22.168 Enzyme
PT-1 (gene name);
PT1L (gene name);
aromatic prenyltransferase (ambiguous)
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
dimethylallyl diphosphate:2-acylphloroglucinol 4-dimethylallyltransferase
dimethylallyl diphosphate + a 2-acylphloroglucinol = diphosphate + a 2-acyl-4-prenylphloroglucinol [RN:
dimethylallyl diphosphate [CPD:
The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids. It also acts with much lower activity on naringenin chalcone. Forms a complex with EC
, 2-acyl-4-prenylphloroglucinol 6-prenyltransferase, which catalyses additional prenylation reactions. Requires Mg2+.
EC 22.214.171.124 created 2017
Tsurumaru Y, Sasaki K, Miyawaki T, Uto Y, Momma T, Umemoto N, Momose M, Yazaki K
HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops.
Biochem Biophys Res Commun 417:393-8 (2012)
Li H, Ban Z, Qin H, Ma L, King AJ, Wang G
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.
Plant Physiol 167:650-9 (2015)
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