Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy

dimethylallyl diphosphate:2-acylphloroglucinol 4-dimethylallyltransferase

dimethylallyl diphosphate + a 2-acylphloroglucinol = diphosphate + a 2-acyl-4-prenylphloroglucinol [RN:R11609]

R11609
Reaction

dimethylallyl diphosphate [CPD:C00235];
2-acylphloroglucinol [CPD:C21498]

The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids. It also acts with much lower activity on naringenin chalcone. Forms a complex with EC 2.5.1.137, 2-acyl-4-prenylphloroglucinol 6-prenyltransferase, which catalyses additional prenylation reactions. Requires Mg2+.

EC 2.5.1.136 created 2017

1  [PMID:22166201]

Tsurumaru Y, Sasaki K, Miyawaki T, Uto Y, Momma T, Umemoto N, Momose M, Yazaki K

HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops.

Biochem Biophys Res Commun 417:393-8 (2012)
DOI:10.1016/j.bbrc.2011.11.125

[ag:BAJ61049]

2  [PMID:25564559]

Li H, Ban Z, Qin H, Ma L, King AJ, Wang G

A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.

Plant Physiol 167:650-9 (2015)
DOI:10.1104/pp.114.253682

[ag:AJD80254]