Entry |
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Name |
lycopene elongase/hydratase (flavuxanthin-forming);
crtEb (gene name)
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Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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Sysname |
dimethylallyl-diphosphate:all-trans-lycopene dimethylallyltransferase (hydrating, flavuxanthin-forming)
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Reaction(IUBMB) |
(1) dimethylallyl diphosphate + all-trans-lycopene + acceptor + H2O = nonaflavuxanthin + reduced electron acceptor + diphosphate [RN: R12283];
(2) dimethylallyl diphosphate + nonaflavuxanthin + acceptor + H2O = flavuxanthin + reduced electron acceptor + diphosphate [RN: R12284]
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Reaction(KEGG) |
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Substrate |
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Product |
nonaflavuxanthin [CPD: C22056];
reduced electron acceptor;
diphosphate [CPD: C00013];
flavuxanthin [CPD: C22057]
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Comment |
The enzyme, characterized from the bacterium Corynebacterium glutamicum, is bifunctional. It catalyses the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2, as well as the hydroxylation of the new isoprene unit. The enzyme acts at both ends of the substrate, forming the C50 carotenoid flavuxanthin via the C45 intermediate nonaflavuxanthin. cf. EC 2.5.1.150, lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming).
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History |
EC 2.5.1.149 created 2018
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Orthology |
K23155 | lycopene elongase/hydratase (flavuxanthin-forming) |
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Genes |
» show all
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Reference |
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Authors |
Krubasik P, Kobayashi M, Sandmann G |
Title |
Expression and functional analysis of a gene cluster involved in the synthesis of decaprenoxanthin reveals the mechanisms for C50 carotenoid formation. |
Journal |
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Sequence |
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Reference |
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Authors |
Heider SA, Peters-Wendisch P, Wendisch VF |
Title |
Carotenoid biosynthesis and overproduction in Corynebacterium glutamicum. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.5.1.149 |
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LinkDB |
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