KEGG ENZYME: 2.5.1.23

ENZYME: 2.5.1.23

Entry

EC 2.5.1.23                 Enzyme

Name

sym-norspermidine synthase;
S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase;
S-adenosyl 3-(methylthio)propylamine:propane-1,3-diamine 3-aminopropyltransferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

S-adenosyl 3-(methylsulfanyl)propylamine:propane-1,3-diamine 3-aminopropyltransferase

Reaction(IUBMB)

S-adenosyl 3-(methylsulfanyl)propylamine + propane-1,3-diamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine [RN:R03271]

Reaction(KEGG)

R03271

Substrate

S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
propane-1,3-diamine [CPD:C00986]

Product

S-methyl-5'-thioadenosine [CPD:C00170];
bis(3-aminopropyl)amine [CPD:C03375]

Comment

The enzyme has been originally characterized from the protist Euglena gracilis [1,2]. The enzyme from the archaeon Sulfolobus solfataricus can transfer the propylamine moiety from S-adenosyl 3-(methylsulfanyl)propylamine to putrescine, sym-norspermidine and spermidine with lower efficiency [3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.22 (spermine synthase).

History

EC 2.5.1.23 created 1983, modified 2013

Reference

1 [PMID:116684]

Authors

Aleksijevic A, Grove J, Schuber F.

Title

Studies on polyamine biosynthesis in Euglena gracilis.

Journal

Biochim Biophys Acta 565:199-207 (1979)
DOI:10.1016/0005-2787(79)90096-0

Reference

Authors

Villanueva VR, Adlakha RC, Calbayrac R.

Title

Biosynthesis of polyamines in Euglena gracilis.

Journal

Phytochemistry 19:787-790 (1980)

Reference

3 [PMID:3096734]

Authors

Cacciapuoti G, Porcelli M, Carteni-Farina M, Gambacorta A, Zappia V

Title

Purification and characterization of propylamine transferase from Sulfolobus solfataricus, an extreme thermophilic archaebacterium.

Journal

Eur J Biochem 161:263-71 (1986)
DOI:10.1111/j.1432-1033.1986.tb10442.x

Sequence

[sso:SSO0757]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.23

IUBMB Enzyme Nomenclature:

2.5.1.23

ExPASy - ENZYME nomenclature database:

2.5.1.23

BRENDA, the Enzyme Database:

2.5.1.23

LinkDB

DBGET integrated database retrieval system