Entry |
|
Name |
sym-norspermidine synthase;
S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase;
S-adenosyl 3-(methylthio)propylamine:propane-1,3-diamine 3-aminopropyltransferase
|
Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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Sysname |
S-adenosyl 3-(methylsulfanyl)propylamine:propane-1,3-diamine 3-aminopropyltransferase
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Reaction(IUBMB) |
S-adenosyl 3-(methylsulfanyl)propylamine + propane-1,3-diamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine [RN: R03271]
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Reaction(KEGG) |
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Substrate |
S-adenosyl 3-(methylsulfanyl)propylamine [CPD: C01137];
propane-1,3-diamine [CPD: C00986]
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Product |
S-methyl-5'-thioadenosine [CPD: C00170];
bis(3-aminopropyl)amine [CPD: C03375]
|
Comment |
The enzyme has been originally characterized from the protist Euglena gracilis [1,2]. The enzyme from the archaeon Sulfolobus solfataricus can transfer the propylamine moiety from S-adenosyl 3-(methylsulfanyl)propylamine to putrescine, sym-norspermidine and spermidine with lower efficiency [3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.22 (spermine synthase).
|
History |
EC 2.5.1.23 created 1983, modified 2013
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Reference |
|
Authors |
Aleksijevic A, Grove J, Schuber F. |
Title |
Studies on polyamine biosynthesis in Euglena gracilis. |
Journal |
|
Reference |
2 |
Authors |
Villanueva, V.R., Adlakha, R.C. and Calbayrac, R. |
Title |
Biosynthesis of polyamines in Euglena gracilis. |
Journal |
Phytochemistry 19:787-790 (1980) |
Reference |
|
Authors |
Cacciapuoti G, Porcelli M, Carteni-Farina M, Gambacorta A, Zappia V |
Title |
Purification and characterization of propylamine transferase from Sulfolobus solfataricus, an extreme thermophilic archaebacterium. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.5.1.23 |
ExPASy - ENZYME nomenclature database: | 2.5.1.23 |
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LinkDB |
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