KEGG ENZYME: 2.5.1.53

ENZYME: 2.5.1.53

Entry

EC 2.5.1.53                 Enzyme

Name

uracilylalanine synthase;
O3-acetyl-L-serine acetate-lyase (adding uracil);
isowillardiine synthase;
willardiine synthase;
3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase;
O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase

Reaction(IUBMB)

O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate [RN:R03131]

Reaction(KEGG)

R03131

Substrate

O-acetyl-L-serine [CPD:C00979];
uracil [CPD:C00106]

Product

3-(uracil-1-yl)-L-alanine [CPD:C03584];
acetate [CPD:C00033]

Comment

The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Acacia willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC 2.5.1.47 cysteine synthase.

History

EC 2.5.1.53 created 1990 as EC 4.2.99.16, transferred 2002 to EC 2.5.1.53

Reference

Authors

Ahmmad MAS, Maskall CS, Brown EG.

Title

Partial-purification and properties of willardiine and synthase activity from Pisum sativum.

Journal

Phytochemistry 23:265-270 (1984)

Reference

Authors

Ikegami F, Kaneko M, Lambein F, Kuo Y-H, Murakoshi I.

Title

Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum.

Journal

Phytochemistry 26:2699-2704 (1987)

Reference

Authors

Murakoshi I, Ikegami F, Ookawa N, Ariki T, Haginiwa J, Kuo Y-H, Lambein F.

Title

Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants.

Journal

Phytochemistry 17:1571-1576 (1978)

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.53

IUBMB Enzyme Nomenclature:

2.5.1.53

ExPASy - ENZYME nomenclature database:

2.5.1.53

BRENDA, the Enzyme Database:

2.5.1.53

CAS:	113573-73-2

LinkDB

DBGET integrated database retrieval system