| Entry |
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| Name |
pseudaminic acid synthase;
PseI;
NeuB3
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
phosphoenolpyruvate:2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose transferase (phosphate-hydrolysing, 2,7-acetylamino-transfering, 2-carboxy-2-oxoethyl-forming)
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| Reaction(IUBMB) |
phosphoenolpyruvate + 2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose + H2O = 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid + phosphate [RN: R09841]
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| Reaction(KEGG) |
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| Substrate |
phosphoenolpyruvate [CPD: C00074];
2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose;
H2O [CPD: C00001]
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| Product |
5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid [CPD: C20082];
phosphate [CPD: C00009]
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| Comment |
The enzyme requires a divalent metal ion, the highest activity values are observed in the presence of Mn2+ and Co2+ (10 mM).
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| History |
EC 2.5.1.97 created 2011
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
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| Orthology |
| K15898 | pseudaminic acid synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Chou WK, Dick S, Wakarchuk WW, Tanner ME |
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| Title |
Identification and characterization of NeuB3 from Campylobacter jejuni as a pseudaminic acid synthase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.97 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.97 |
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| LinkDB |
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