KEGG   ENZYME: 2.7.7.106
Entry
EC 2.7.7.106                Enzyme                                 

Name
3-phospho-D-glycerate guanylyltransferase;
cofC (gene name) (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
GTP:3-phospho-D-glycerate guanylyltransferase
Reaction(IUBMB)
3-phospho-D-glycerate + GTP = 3-(D-glyceryl)-diphospho-5'-guanosine + diphosphate [RN:R12647]
Reaction(KEGG)
R12647
Substrate
3-phospho-D-glycerate [CPD:C00197];
GTP [CPD:C00044]
Product
3-(D-glyceryl)-diphospho-5'-guanosine [CPD:C22298];
diphosphate [CPD:C00013]
Comment
The enzyme, characterized from the Gram-negative bacterium Paraburkholderia rhizoxinica, participates in the biosynthesis of 3PG-factor 420. The enzyme can also accept 2-phospho-L-lactate and phosphoenolpyruvate, but activity is much higher with 3-phospho-D-glycerate. cf. EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase and EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase.
History
EC 2.7.7.106 created 2020
Reference
1  [PMID:31469543]
  Authors
Braga D, Last D, Hasan M, Guo H, Leichnitz D, Uzum Z, Richter I, Schalk F, Beemelmanns C, Hertweck C, Lackner G
  Title
Metabolic Pathway Rerouting in Paraburkholderia rhizoxinica Evolved Long-Overlooked Derivatives of Coenzyme F420.
  Journal
ACS Chem Biol 14:2088-2094 (2019)
DOI:10.1021/acschembio.9b00605
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.106
IUBMB Enzyme Nomenclature: 2.7.7.106
ExPASy - ENZYME nomenclature database: 2.7.7.106
BRENDA, the Enzyme Database: 2.7.7.106
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