KEGG ENZYME: 2.7.7.106

ENZYME: 2.7.7.106

Entry

EC 2.7.7.106 Enzyme

Name

3-phospho-D-glycerate guanylyltransferase;
cofC (gene name) (ambiguous)

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

GTP:3-phospho-D-glycerate guanylyltransferase

Reaction(IUBMB)

3-phospho-D-glycerate + GTP = 3-(D-glyceryl)-diphospho-5'-guanosine + diphosphate [RN:R12647]

Reaction(KEGG)

R12647

Substrate

3-phospho-D-glycerate [CPD:C00197];
GTP [CPD:C00044]

Product

3-(D-glyceryl)-diphospho-5'-guanosine [CPD:C22298];
diphosphate [CPD:C00013]

Comment

The enzyme, characterized from the Gram-negative bacterium Paraburkholderia rhizoxinica, participates in the biosynthesis of 3PG-factor 420. The enzyme can also accept 2-phospho-L-lactate and phosphoenolpyruvate, but activity is much higher with 3-phospho-D-glycerate. cf. EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase and EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase.

History

EC 2.7.7.106 created 2020

Reference

1 [PMID:31469543]

Authors

Braga D, Last D, Hasan M, Guo H, Leichnitz D, Uzum Z, Richter I, Schalk F, Beemelmanns C, Hertweck C, Lackner G

Title

Metabolic Pathway Rerouting in Paraburkholderia rhizoxinica Evolved Long-Overlooked Derivatives of Coenzyme F420.

Journal

ACS Chem Biol 14:2088-2094 (2019)
DOI:10.1021/acschembio.9b00605

Sequence

[brh:RBRH_02550]