KEGG ENZYME: 2.7.7.28

ENZYME: 2.7.7.28

Entry

EC 2.7.7.28                 Enzyme

Name

nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase;
NDP hexose pyrophosphorylase;
hexose 1-phosphate nucleotidyltransferase;
hexose nucleotidylating enzyme;
nucleoside diphosphohexose pyrophosphorylase;
hexose-1-phosphate guanylyltransferase;
GTP:alpha-D-hexose-1-phosphate guanylyltransferase;
GDP hexose pyrophosphorylase;
guanosine diphosphohexose pyrophosphorylase;
nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase;
NTP:hexose-1-phosphate nucleotidyltransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase

Reaction(IUBMB)

nucleoside triphosphate + alpha-D-aldose 1-phosphate = diphosphate + NDP-hexose [RN:R03149]

Reaction(KEGG)

R03149 > R03318

Substrate

nucleoside triphosphate [CPD:C00201];
alpha-D-aldose 1-phosphate [CPD:C00991]

Product

diphosphate [CPD:C00013];
NDP-hexose [CPD:C01600]

Comment

In decreasing order of activity, guanosine, inosine and adenosine diphosphate hexoses are substrates in the reverse reaction, with either glucose or mannose as the sugar.

History

EC 2.7.7.28 created 1972, modified 2004 (EC 2.7.7.29 created 1972, incorporated 2004)

Reference

1 [PMID:5946626]

Authors

Verachtert H, Rodriguez P, Bass ST, Hansen RG.

Title

Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues.

Journal

J Biol Chem 241:2007-13 (1966)

Reference

Authors

Hansen RG, Verachtert H, Rodriguez P, Bass ST.

Title

GDP-hexose pyrophosphorylase from liver.

Journal

Methods Enzymol 8:269-271 (1966)

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.28

IUBMB Enzyme Nomenclature:

2.7.7.28

ExPASy - ENZYME nomenclature database:

2.7.7.28

BRENDA, the Enzyme Database:

2.7.7.28

CAS:	37278-26-5

LinkDB

DBGET integrated database retrieval system