| Entry |
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| Name |
N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase;
murU (gene name)
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
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| Sysname |
UDP:N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase
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| Reaction(IUBMB) |
UDP + N-acetyl-alpha-D-muramate 1-phosphate = UDP-N-acetyl-alpha-D-muramate + phosphate
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| Reaction(KEGG) |
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| Substrate |
UDP [CPD: C00015];
N-acetyl-alpha-D-muramate 1-phosphate [CPD: C21027]
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| Product |
UDP-N-acetyl-alpha-D-muramate [CPD: C01050];
phosphate [CPD: C00009]
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| Comment |
The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway.
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| History |
EC 2.7.7.99 created 2017
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
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| Orthology |
| K00992 | N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Gisin J, Schneider A, Nagele B, Borisova M, Mayer C |
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| Title |
A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Renner-Schneck M, Hinderberger I, Gisin J, Exner T, Mayer C, Stehle T |
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| Title |
Crystal Structure of the N-Acetylmuramic Acid alpha-1-Phosphate (MurNAc-alpha1-P) Uridylyltransferase MurU, a Minimal Sugar Nucleotidyltransferase and Potential Drug Target Enzyme in Gram-negative Pathogens. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.7.99 |
| ExPASy - ENZYME nomenclature database: | 2.7.7.99 |
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| LinkDB |
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