KEGG   ENZYME: 2.7.8.2
Entry
EC 2.7.8.2                  Enzyme                                 

Name
diacylglycerol cholinephosphotransferase;
phosphorylcholine-glyceride transferase;
alkylacylglycerol cholinephosphotransferase;
1-alkyl-2-acetylglycerol cholinephosphotransferase;
cholinephosphotransferase;
CPT (ambiguous);
alkylacylglycerol choline phosphotransferase;
diacylglycerol choline phosphotransferase;
1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase;
CDP-choline diglyceride phosphotransferase;
cytidine diphosphocholine glyceride transferase;
cytidine diphosphorylcholine diglyceride transferase;
phosphocholine diacylglyceroltransferase;
sn-1,2-diacylglycerol cholinephosphotransferase;
1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase;
CDP choline:1,2-diacylglycerol cholinephosphotransferase;
CDP-choline:1,2-diacylglycerol cholinephosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase
Reaction(IUBMB)
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine [RN:R01321]
Reaction(KEGG)
R01321;
(other) R04321 R04922 R07389
Substrate
CDP-choline [CPD:C00307];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CMP [CPD:C00055];
phosphatidylcholine [CPD:C00157]
Comment
1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately.
History
EC 2.7.8.2 created 1961, modified 1986 (EC 2.7.8.16 created 1983, incorporated 1986)
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec00564  Glycerophospholipid metabolism
ec00565  Ether lipid metabolism
ec01100  Metabolic pathways
Orthology
K00994  diacylglycerol cholinephosphotransferase
K13644  choline/ethanolamine phosphotransferase
Genes
HSA: 10390(CEPT1) 56994(CHPT1)
PTR: 457116(CEPT1) 467109(CHPT1)
PPS: 100975614(CEPT1) 100986998(CHPT1)
GGO: 101146100(CEPT1) 101151506(CHPT1)
PON: 100439046(CEPT1) 100440613(CHPT1)
NLE: 100599371(CEPT1) 100605676(CHPT1)
MCC: 696056(CHPT1) 702700(CEPT1)
MCF: 101926162(CEPT1) 102122766(CHPT1)
CSAB: 103224236(CEPT1) 103238948(CHPT1)
RRO: 104657409(CHPT1) 104658945(CEPT1)
RBB: 108528075(CEPT1) 108538927(CHPT1)
CJC: 100388578(CEPT1)
SBQ: 101043338(CEPT1) 101052362(CHPT1)
MMU: 212862(Chpt1) 99712(Cept1)
MCAL: 110291241(Cept1) 110303094(Chpt1)
MPAH: 110320080(Cept1) 110326383(Chpt1)
RNO: 310773(Cept1) 362866(Chpt1)
MUN: 110550296(Chpt1) 110550756(Cept1)
CGE: 100750762(Chpt1) 100773070(Cept1)
NGI: 103733732(Chpt1) 103747803(Cept1)
HGL: 101711138(Chpt1) 101721378(Cept1)
CCAN: 109690293(Chpt1) 109699595(Cept1)
OCU: 100353363(CEPT1) 100353669(CHPT1)
TUP: 102485648(CHPT1) 102499314(CEPT1)
CFA: 610214(CHPT1) 612948(CEPT1)
VVP: 112907235(CEPT1) 112930674(CHPT1)
AML: 100473311(CEPT1) 100484386(CHPT1)
UMR: 103675028(CEPT1) 103676503(CHPT1)
UAH: 113244896(CEPT1) 113256089(CHPT1)
ORO: 101377488(CHPT1) 101385081(CEPT1)
FCA: 101093451(CEPT1) 101099986(CHPT1)
PTG: 102961960(CHPT1) 102967463(CEPT1)
PPAD: 109265407(CHPT1) 109272032(CEPT1)
AJU: 106971875(CHPT1) 106978009(CEPT1)
BTA: 504650(CEPT1) 511291(CHPT1)
BOM: 102269460(CHPT1) 102273094(CEPT1)
BIU: 109555949(CEPT1) 109558502(CHPT1)
BBUB: 102389799(CHPT1) 102404689(CEPT1)
CHX: 102175100(CHPT1) 102182086(CEPT1)
OAS: 101108821(CHPT1) 101112775(CEPT1)
SSC: 100154792(CEPT1) 100523738(CHPT1)
CFR: 102508627(CHPT1) 102513980(CEPT1)
BACU: 102998184(CEPT1) 103018700(CHPT1)
LVE: 103072539(CEPT1) 103085556(CHPT1)
OOR: 101272174(CHPT1) 101285127(CEPT1)
DLE: 111180041(CEPT1) 111187809(CHPT1)
PCAD: 102976930(CHPT1) 102988749(CEPT1)
ECB: 100062845(CEPT1) 106782693(CHPT1)
EPZ: 103547790(CEPT1) 103555701(CHPT1)
EAI: 106827266(CHPT1) 106828607(CEPT1)
MYB: 102257668(CHPT1) 102263162(CEPT1)
MYD: 102755578(CHPT1) 102763884(CEPT1)
MNA: 107545157(CHPT1) 107545321(CEPT1)
HAI: 109371576(CEPT1) 109387759(CHPT1)
DRO: 112313540(CEPT1) 112321764(CHPT1)
PALE: 102892767(CHPT1) 102898529(CEPT1)
RAY: 107501169(CHPT1) 107516123(CEPT1)
MJV: 108391619(CEPT1) 108400202(CHPT1)
LAV: 100674609(CEPT1) 104846858(CHPT1)
MDO: 100020969(CHPT1) 100030357(CEPT1)
SHR: 100933929(CEPT1) 116419654(CHPT1)
PCW: 110205641(CHPT1) 110218608(CEPT1)
OAA: 100075425(CHPT1) 100081592(CEPT1)
GGA: 418098(CHPT1) 421152(CEPT1)
MGP: 100546891 100550822(CEPT1)
CJO: 107316205(CHPT1) 107324694(CEPT1)
NMEL: 110388353(CEPT1) 110394003(CHPT1)
APLA: 101791878(CHPT1) 101801996(CEPT1)
ACYG: 106031029(CHPT1) 106046152(CEPT1)
TGU: 100219217(CEPT1) 100219586(CHPT1)
LSR: 110469172(CEPT1) 110473685(CHPT1)
SCAN: 103819647(CHPT1) 103822374(CEPT1)
GFR: 102039926(CHPT1) 102042695(CEPT1)
FAB: 101806735(CHPT1) 101813197(CEPT1)
PHI: 102104902(CEPT1) 102108343(CHPT1)
PMAJ: 107204414(CHPT1) 107214859(CEPT1)
CCAE: 111936201(CHPT1) 111939633(CEPT1)
CCW: 104692467(CEPT1) 104696223(CHPT1)
ETL: 114056155(CHPT1) 114071758
FPG: 101911330(CHPT1) 101917473(CEPT1)
FCH: 102046063(CEPT1) 102048528(CHPT1)
CLV: 102084659 102086581(CHPT1)
EGZ: 104121991(CEPT1) 104135594(CHPT1)
NNI: 104011091(CEPT1) 104013380(CHPT1)
ACUN: 113488607(CHPT1) 113489052(CEPT1)
PADL: 103924522(CHPT1) 103926254(CEPT1)
AAM: 106485642(CEPT1) 106488652(CHPT1)
ASN: 102368380(CEPT1) 102382218(CHPT1)
AMJ: 102560772(CEPT1) 102570848(CHPT1)
PSS: 102458739(CHPT1) 102461379(CEPT1)
CMY: 102933991(CHPT1) 102946218(CEPT1)
CPIC: 101937224(CHPT1) 101940701(CEPT1)
ACS: 100561765(chpt1) 100567654(cept1)
PVT: 110073385(CEPT1) 110082685(CHPT1)
PBI: 103064252(CHPT1) 103064689(CEPT1)
TSR: 106548630(CEPT1) 106549827(CHPT1)
PMUA: 114599437(CEPT1) 114605357(CHPT1)
GJA: 107114824(CEPT1) 107119583(CHPT1)
XLA: 108713210(chpt1.S) 379805(cept1.S) 734631(chpt1.L)
XTR: 100216268(chpt1) 549188(cept1)
NPR: 108787169(CHPT1) 108804882(CEPT1)
DRE: 322605(chpt1) 560225(cept1a) 570720(cept1b)
IPU: 100305100(cept1) 108265319 108274771(chpt1)
PHYP: 113529631(chpt1)
AMEX: 103025726(cept1) 103031285(chpt1) 103046724
EEE: 113586961(cept1) 113587966 113588005(chpt1)
TRU: 101078788(cept1)
LCO: 104926726(chpt1) 104927824(cept1)
NCC: 104950095(chpt1) 104961372(cept1)
MZE: 101474280(cept1) 101476120(chpt1)
ONL: 100697159(cept1) 100703364(chpt1)
OLA: 101173516(chpt1)
XMA: 102225565(cept1) 102235171(chpt1)
XCO: 114135685(cept1) 114160853(chpt1)
PRET: 103459173(chpt1) 103464802
CVG: 107085961 107093179(cept1)
NFU: 107384952(cept1) 107386145(chpt1)
KMR: 108233186(chpt1) 108244951(cept1)
ALIM: 106522857(cept1) 106534105
AOCE: 111575997(cept1) 111582864
CSEM: 103382702(chpt1) 103386450(cept1)
POV: 109641563 109642404(cept1)
LCF: 108889793(cept1) 108890214(chpt1)
SDU: 111219428(cept1) 111225032(chpt1)
SLAL: 111656498(chpt1) 111662327(cept1)
HCQ: 109510326(cept1) 109523684
BPEC: 110161596(chpt1) 110162476(cept1)
MALB: 109959927(chpt1) 109966394(cept1)
LCM: 102361623(CHPT1) 102364240(CEPT1)
CMK: 103179874(chpt1) 103190121(cept1)
RTP: 109937061(cept1)
CIN: 100176633
SPU: 763773
APLC: 110979864
DER: 6549550
DPE: 6592752
DWI: 6637888
DAZ: 108615613
DNV: 108653836
DHE: 111599715
LCQ: 111677410
AAG: 5564361
AME: 552795
BIM: 100743718
BTER: 100648463
CCAL: 108630752
OBB: 114873119
SOC: 105199340
MPHA: 105835416
AEC: 105144198
ACEP: 105618031
PBAR: 105433149
VEM: 105564112
HST: 105184799
DQU: 106749738
CFO: 105254704
LHU: 105672484
PGC: 109861346
OBO: 105275992
PCF: 106791137
NVI: 100118853
CSOL: 105362583
MDL: 103569897
DPA: 109535370
ATD: 109598181
NVL: 108559838
BMOR: 101747123
BMAN: 114243587
PMAC: 106709609
PRAP: 110998327
HAW: 110375203
TNL: 113507303
API: 100160590
AGS: 114129453
RMD: 113557302
BTAB: 109030120
CLEC: 106670009
ZNE: 110826593
FCD: 110850762
PVM: 113814834
TUT: 107363409
DPTE: 113795927
CSCU: 111629693
TSP: Tsp_04639
PCAN: 112560592
CRG: 105326860
MYI: 110453160
OBI: 106867824
NVE: 5501998
EPA: 110249485
ADF: 107349498
AMIL: 114956904
PDAM: 113667768
SPIS: 111325395
HMG: 101234743
AQU: 100638347
SCE: YNL130C(CPT1)
ERC: Ecym_8190
KMX: KLMA_60263(CPT1)
NCS: NCAS_0G02370(NCAS0G02370)
NDI: NDAI_0B04390(NDAI0B04390) NDAI_0F02920(NDAI0F02920)
TPF: TPHA_0I01400(TPHA0I01400)
TBL: TBLA_0B01190(TBLA0B01190) TBLA_0D00380(TBLA0D00380)
TDL: TDEL_0B05000(TDEL0B05000)
KAF: KAFR_0J02190(KAFR0J02190)
 » show all
Reference
1  [PMID:192727]
  Authors
Coleman R, Bell RM.
  Title
Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities.
  Journal
J Biol Chem 252:3050-6 (1977)
Reference
2  [PMID:6295501]
  Authors
Lee TC, Blank ML, Fitzgerald V, Snyder F.
  Title
Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver.
  Journal
Biochim Biophys Acta 713:479-83 (1982)
DOI:10.1016/0005-2760(82)90269-7
Reference
3  [PMID:204847]
  Authors
Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ.
  Title
Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate.
  Journal
Lipids 13:161-4 (1978)
DOI:10.1007/BF02533260
Reference
4  [PMID:6260215]
  Authors
Renooij W, Snyder F.
  Title
Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues.
  Journal
Biochim Biophys Acta 663:545-56 (1981)
DOI:10.1016/0005-2760(81)90182-X
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.2
IUBMB Enzyme Nomenclature: 2.7.8.2
ExPASy - ENZYME nomenclature database: 2.7.8.2
BRENDA, the Enzyme Database: 2.7.8.2
CAS: 9026-13-5
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