KEGG   ENZYME: 2.8.3.22
Entry
EC 2.8.3.22                 Enzyme                                 

Name
succinyl-CoA---L-malate CoA-transferase;
SmtAB
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
Sysname
succinyl-CoA:(S)-malate CoA-transferase
Reaction(IUBMB)
(1) succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA [RN:R00406];
(2) succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA [RN:R03154]
Reaction(KEGG)
R00406 R03154
Substrate
succinyl-CoA [CPD:C00091];
(S)-malate [CPD:C00149];
(S)-citramalate [CPD:C02614]
Product
succinate [CPD:C00042];
(S)-malyl-CoA [CPD:C04348];
(S)-citramalyl-CoA [CPD:C01011]
Comment
The enzyme, purified from the bacterium Chloroflexus aurantiacus, can also accept itaconate as acceptor, with lower efficiency. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 2.8.3.22 created 2014
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14471  succinyl-CoA:(S)-malate CoA-transferase subunit A
K14472  succinyl-CoA:(S)-malate CoA-transferase subunit B
K18289  itaconate CoA-transferase
Genes
PGE: LG71_13505
PAE: PA0882
PAEV: N297_910
PAEI: N296_910
PAU: PA14_52870
PAP: PSPA7_4632
PAG: PLES_44341
PAF: PAM18_4157
PNC: NCGM2_1660
PAEB: NCGM1900_1840
PAEP: PA1S_22030
PAEM: U769_21400
PAEL: T223_22665
PAEG: AI22_11910
PAEC: M802_906
PAEO: M801_910
PMK: MDS_3404
PPSE: BN5_1316
PCQ: PcP3B5_31090(frc_3)
PPUN: PP4_26590
PSB: Psyr_2175
PFL: PFL_2650
PPRO: PPC_2699
PFS: PFLU_3473
PFB: VO64_0586
PSA: PST_1697
PSTT: CH92_08225
PSES: PSCI_4461
PSEM: TO66_12955
PSIL: PMA3_18310
PALL: UYA_16450
AUG: URS_0099
LLG: 44548918_02119(frc)
ADI: B5T_02015
APAC: S7S_06585
AXE: P40_09635
CGD: CR3_0428(caiB)
BTD: BTI_2434
BOK: DM82_900
BOC: BG90_35
BVE: AK36_3487
BCN: Bcen_5809
BCJ: BCAS0021
BCEN: DM39_6414
BCEW: DM40_5519
BCEO: I35_7020
BAM: Bamb_6269
BMK: DM80_1411
BCED: DM42_6392
BCON: NL30_35115
BUB: BW23_6275
BPSL: WS57_16950
BMEC: WJ16_18910
BSTG: WT74_17815
BGO: BM43_2915
BUL: BW21_2401
BPH: Bphy_4945
PNU: Pnuc_1389
PPNO: DA70_03750
PPNM: LV28_02565
PPUL: RO07_21515
PSPU: NA29_15815
PAPI: SG18_20340
PLG: NCTC10937_02758(frc_1)
BPAR: BN117_0346
BHO: D560_1019
BHM: D558_1005
BHZ: ACR54_03834(frc_9)
AXX: ERS451415_00903(frc_3)
TEA: KUI_1573
TEG: KUK_0904
TAS: TASI_1544
TAT: KUM_1149
PUT: PT7_0056
AMIM: MIM_c40130
RFR: Rfer_3485
AJS: Ajs_0117
VEI: Veis_4805
CTES: O987_01130
RTA: Rta_16640
LIH: L63ED372_02959(frc_3)
HPSE: HPF_12655(frc1)
HSE: Hsero_2797(caiB)
HRB: Hrubri_2848(caiB)
LCH: Lcho_2416
AZA: AZKH_1922
CCQ: N149_0441
CCF: YSQ_07645
CCY: YSS_02010
CCOI: YSU_06655
CCOF: VC76_02325(frc)
CCOO: ATE51_03326(frc)
BMEL: DK63_2182
BMEE: DK62_2094
BABO: DK55_2160
BABR: DO74_2287
BABT: DK49_2268
BABB: DK48_2532
BABU: DK53_2975
BABS: DK51_2463
BABC: DO78_3182
BSZ: DK67_2187
BOV: BOV_A0147
BCAR: DK60_3042
BCAS: DA85_11295
BMR: BMI_II163
BPP: BPI_II163
BPV: DK65_2306
BBT: BBta_6664
BRS: S23_58700
RPB: RPB_3936
RPT: Rpal_1801
VGO: GJW-30_1_00417(frc_2)
SNO: Snov_3517
MNO: Mnod_6787
MAQU: Maq22A_c12690(caiB)
BID: Bind_2536
SPSE: SULPSESMR1_04146(yfdE)
RID: RIdsm_03587(frc_6)
MARU: FIU81_05545(bbsF)
SPHP: LH20_19545
SMAZ: LH19_26470
SPHD: HY78_30015
SECH: B18_16060
SPHT: K426_18730
SMIC: SmB9_16430
ACR: Acry_2578
MIT: OCO_14320
MIA: OCU_14780
MIR: OCQ_28570
MMC: Mmcs_3742
MKM: Mkms_3815
MVA: Mvan_4208
MGI: Mflv_2443
MPHL: MPHLCCUG_03775(frc_4)
MTHN: 4412656_03069(frc_11)
MHAS: MHAS_02595(smtB_2)
MTER: 4434518_00718(frc_3)
CPSE: CPTA_01735
CPSU: CPTB_02028
CPSF: CPTC_01726
RER: RER_52090
REY: O5Y_24645
RRT: 4535765_04348(frc_10)
RCR: NCTC10994_03025(frc_4)
GRU: GCWB2_12120(frc5)
GOM: D7316_02162(yfdE_2) D7316_02375(yfdE_3)
SALB: XNR_0226
SGB: WQO_06375
SFA: Sfla_1417
SHY: SHJG_3170
SVE: SVEN_1337
SALS: SLNWT_6159
STRP: F750_5463
SALU: DC74_7458
SALL: SAZ_38515
STRE: GZL_01187
SPRI: SPRI_5820
SRW: TUE45_02185(frc_1)
STRD: NI25_23140
SLAU: SLA_0538
SALF: SMD44_01319(frc)
SALJ: SMD11_0726
SFK: KY5_1012
SGE: DWG14_00638(yfdE)
SRJ: SRO_5753
AUW: AURUGA1_01429(frc)
BLIN: BLSMQ_0276
NDA: Ndas_1193
FAL: FRAAL3412
SEN: SACE_4588
AMN: RAM_23535
AMM: AMES_4566
AMZ: B737_4566
AOI: AORI_4919(mcr)
AMYY: YIM_08245(frc2)
PSEA: WY02_08930
PSEE: FRP1_19745
PSEH: XF36_05585
ALO: CRK55392
ACTN: L083_5712
RXY: Rxyl_2734
HAU: Haur_2263
STI: Sthe_1793
NMG: Nmag_3456
 » show all
Reference
1  [PMID:16547052]
  Authors
Friedmann S, Steindorf A, Alber BE, Fuchs G.
  Title
Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J Bacteriol 188:2646-55 (2006)
DOI:10.1128/JB.188.7.2646-2655.2006
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.22
IUBMB Enzyme Nomenclature: 2.8.3.22
ExPASy - ENZYME nomenclature database: 2.8.3.22
BRENDA, the Enzyme Database: 2.8.3.22
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