KEGG   ENZYME: 2.8.3.9
Entry
EC 2.8.3.9                  Enzyme                                 

Name
butyrate---acetoacetate CoA-transferase;
butyryl coenzyme A-acetoacetate coenzyme A-transferase;
butyryl-CoA-acetoacetate CoA-transferase
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
Sysname
butanoyl-CoA:acetoacetate CoA-transferase
Reaction(IUBMB)
butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA [RN:R01365]
Reaction(KEGG)
R01365
Substrate
butanoyl-CoA [CPD:C00136];
acetoacetate [CPD:C00164]
Product
butanoate [CPD:C00246];
acetoacetyl-CoA [CPD:C00332]
Comment
Butanoate, acetoacetate and their CoA thioesters are the preferred substrates, but the enzyme also acts, more slowly, on the derivatives of a number of C2 to C6 monocarboxylic acids.
History
EC 2.8.3.9 created 1984
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K01034  acetate CoA/acetoacetate CoA-transferase alpha subunit
K01035  acetate CoA/acetoacetate CoA-transferase beta subunit
Genes
ECO: b2221(atoD) b2222(atoA)
ECJ: JW2215(atoD) JW2216(atoA)
ECD: ECDH10B_2379(atoD) ECDH10B_2380(atoA)
EBW: BWG_1995(atoD) BWG_1996(atoA)
ECOK: ECMDS42_1789(atoD) ECMDS42_1790(atoA)
ECG: E2348C_2366(atoD) E2348C_2367(atoA)
ELH: ETEC_2355 ETEC_2356
EUN: UMNK88_2770 UMNK88_2771
ECP: ECP_2266
ENA: ECNA114_2314(atoD) ECNA114_2315(atoA)
ECOS: EC958_2558(atoD) EC958_2559(atoA)
ECV: APECO1_4337(atoA) APECO1_4338(atoD)
ECQ: ECED1_2687(atoD) ECED1_2688(atoA)
EUM: ECUMN_2559(atoD) ECUMN_2560(atoA)
ECT: ECIAI39_2359(atoD) ECIAI39_2360(atoA)
EOC: CE10_2596(atoD) CE10_2597(atoA)
EBR: ECB_02148(atoD) ECB_02149(atoA)
EBL: ECD_02148(atoD) ECD_02149(atoA)
EBE: B21_02107(atoD) B21_02108(atoA)
ECI: UTI89_C2503(atoD) UTI89_C2504(atoA)
EIH: ECOK1_2456(pcaI)
ECZ: ECS88_2370(atoD) ECS88_2371(atoA)
ECC: c2764(atoD) c2765(atoA)
ELO: EC042_2462(atoD) EC042_2463(atoA)
EAB: ECABU_c25570(atoD) ECABU_c25580(atoA)
ELC: i14_2562(atoD) i14_2563(atoA)
ELD: i02_2562(atoD) i02_2563(atoA)
ELP: P12B_c2313(atoD) P12B_c2314(atoA)
ELF: LF82_0185(atoA) LF82_0188(atoD)
ECOI: ECOPMV1_02383(atoD_2) ECOPMV1_02384(atoA)
EFE: EFER_0937(atoA) EFER_0938(atoD)
SSN: SSON_2280(atoD) SSON_2281(atoA)
KPT: VK055_4879(atoA) VK055_4880(ctfA)
YIN: CH53_2126(atoA) CH53_2127(atoD)
ECA: ECA1283(atoA) ECA1284(atoD)
PATO: GZ59_13090(atoA) GZ59_13100(atoD)
PLU: plu3799(atoD) plu3800(atoA)
PAY: PAU_01019(atoA) PAU_01020(atoD)
ETR: ETAE_2012(atoD) ETAE_2013(atoA1) ETAE_2119(pcaI) ETAE_2120(atoA2)
ETE: ETEE_4071(atoD) ETEE_4072(atoA)
HIT: NTHI0934(atoA) NTHI0935(atoD)
HIZ: R2866_1620(atoD) R2866_1621(atoA)
HIK: HifGL_000448(atoA) HifGL_000449(atoD)
HIW: NTHI477_00932(atoD) NTHI477_00933(atoA)
HIX: NTHI723_00836(atoD) NTHI723_00837(atoA)
PDAG: 4362423_01901(atoA) 4362423_01902(atoD)
RPNE: NCTC8284_03595(atoD) NCTC8284_03596(atoA_1)
VNI: VIBNI_B0463(ctfB) VIBNI_B0464(ctfA)
HCO: LOKO_02616(atoD)
HBE: BEI_2296(atoD) BEI_2297
BCEN: DM39_3657(ctfB) DM39_3658
BUB: BW23_3843
PBH: AAW51_0375 AAW51_0877(atoD) AAW51_0878(atoA)
AZA: AZKH_p0587(atoA) AZKH_p0588(atoD)
SFU: Sfum_2291
BJA: bll3461(pcaJ) bll3462(pcaI)
FIL: BN1229_v1_3823(atoD) BN1229_v1_3824(atoA)
FIY: BN1229_v1_3813(atoD) BN1229_v1_3814(atoA)
LABT: FIU93_14760(ctfB) FIU93_14765(atoD)
ROH: FIU89_05735(scoA)
AZL: AZL_d00130(atoD) AZL_d00140(scoB)
ALI: AZOLI_p40132(scoA) AZOLI_p40133(scoB)
BSH: BSU6051_19720(yodR) BSU6051_19730(yodS)
BSUT: BSUB_02124(yodR) BSUB_02125(yodS)
BSUL: BSUA_02124(yodR) BSUA_02125(yodS)
BSS: BSUW23_10550(yodR) BSUW23_10555(yodS)
BSO: BSNT_08545(yodR) BSNT_08546(yodS)
BSQ: B657_19720(yodR) B657_19730(yodS)
BSX: C663_2030(yodR) C663_2031(atoD)
BLI: BL01426(yodS)
BLD: BLi02298(yodS)
BLH: BaLi_c23820(yodR) BaLi_c23830(yodS)
BAQ: BACAU_1956(yodR) BACAU_1957(yodS)
BYA: BANAU_2079(yodR) BANAU_2080(yodS)
BAML: BAM5036_1887(yodR) BAM5036_1888(yodS)
BAMA: RBAU_1924(yodR) RBAU_1925(yodS)
BAMN: BASU_1904(yodR) BASU_1905(yodS)
BAMB: BAPNAU_1789(yodS) BAPNAU_1790(yodR)
BAMY: V529_21780(yodR) V529_21790(yodS)
BMP: NG74_02034(scoB_2) NG74_02035(atoD)
BAO: BAMF_2051(yodR) BAMF_2052(yodS)
BAZ: BAMTA208_07245(yodS) BAMTA208_07250(yodR)
BQL: LL3_02154(yodR) LL3_02155(yodS)
BXH: BAXH7_01473(yodS) BAXH7_01474(yodR)
BQY: MUS_2333(yodR) MUS_2334(yodS)
BSON: S101395_02306(atoD) S101395_02307(scoB)
BAN: BA_2295(atoD)
BAR: GBAA_2295(atoD)
BAT: BAS2140
BAI: BAA_2359(atoD) BAA_2360
BANV: DJ46_1092(atoD) DJ46_1093
BCE: BC2246
BCA: BCE_2329(atoD)
BCZ: BCE33L2074(atoD) BCE33L2075(atoA)
BCQ: BCQ_2229(atoD) BCQ_2230(atoA)
BCX: BCA_2376(atoD) BCA_2377
BAL: BACI_c22560(atoD) BACI_c22570(atoA)
BCER: BCK_23365
BTK: BT9727_2078(atoD) BT9727_2079(atoA)
BTM: MC28_1465
BTG: BTB_c23280(yodS) BTB_c23290(yodR)
BTW: BF38_3496(atoD) BF38_3497
BWW: bwei_2749(atoA) bwei_2750(atoD)
BMYC: DJ92_4847
BMET: BMMGA3_10150(yodR) BMMGA3_10155(yodS)
BACL: BS34A_21880(yodR)
BGY: BGLY_2550(yodR) BGLY_2551(yodS)
BFD: NCTC4823_00159(scoB_1) NCTC4823_00160(atoD)
BHA: BH2259
BPF: BpOF4_18595(atoA) BpOF4_18600(atoD)
BKW: BkAM31D_12405(scoB_1) BkAM31D_12410(atoD)
HHD: HBHAL_4175(atoA) HBHAL_4176(atoD)
PASA: BAOM_3338 BAOM_3339(atoD)
LMOE: BN418_2618
LMOB: BN419_2623
PPM: PPSC2_06045(atoA) PPSC2_06050(atoD)
PPO: PPM_1143(atoA) PPM_1144(atoD)
PPQ: PPSQR21_012330(atoA) PPSQR21_012340(atoD)
PRI: PRIO_0483(ctfB1) PRIO_0484 PRIO_1096(atoD) PRIO_1097(ctfB3)
SPY: SPy_0141(atoD.2) SPy_0142 SPy_1638(atoD.1) SPy_1639(atoA)
SPYA: A20_0169(atoD) A20_0170(ctfB) A20_1388(atoD) A20_1389(atoA)
SPG: SpyM3_0109(atoD.2) SpyM3_0110 SpyM3_1379(atoD.1) SpyM3_1380(atoA)
SPF: SpyM50115(atoD1) SpyM50116(atoA1) SpyM50446(atoD2)
SPB: M28_Spy0118(atoD.2) M28_Spy0119(atoA) M28_Spy1386(atoD.1) M28_Spy1387(atoA)
STG: MGAS15252_0156(atoD.1) MGAS15252_0157(atoA.1) MGAS15252_1241(atoD.2) MGAS15252_1242(atoA.2)
STX: MGAS1882_0156(atoD.1) MGAS1882_0157(atoA.1) MGAS1882_1302(atoD.2) MGAS1882_1303(atoA.2)
SOZ: Spy49_0124(atoD.2) Spy49_0125 Spy49_1269(atoD1) Spy49_1270(atoA)
SEZO: SeseC_01932(scoB) SeseC_01933(atoD)
SUB: SUB1395(atoD2) SUB1396(atoA2)
SDS: SDEG_1701(atoD.1) SDEG_1702(atoA)
SDA: GGS_1534(atoD.1) GGS_1535(atoA)
SDC: SDSE_1796(atoD) SDSE_1797(atoA)
SDQ: SDSE167_1761(atoD.1) SDSE167_1762(atoA)
SANG: SAIN_0966(cftB) SAIN_0967(ctfA)
SANC: SANR_1042(cftB) SANR_1043(ctfA)
SCG: SCI_0953(cftB) SCI_0954(ctfA)
SCON: SCRE_0881(cftB) SCRE_0882(ctfA)
SCOS: SCR2_0881(cftB) SCR2_0882(ctfA)
STRN: SNAG_1863(atoA) SNAG_1864(ctfA)
JDA: BW727_101419(atoD)
CAC: CA_P0163(ctfa) CA_P0164(ctfb)
CAE: SMB_P161(ctfa) SMB_P162(ctfb)
CAY: CEA_P0161(ctfa) CEA_P0162(ctfb)
CBO: CBO2847(ctfA) CBO2848(ctfB)
CBI: CLJ_B3081
CSR: Cspa_c21000(atoD1) Cspa_c21010(ctfB1) Cspa_c22630(atoD2) Cspa_c22640(ctfB2) Cspa_c56890(ctfA) Cspa_c56900(ctfB3)
CPAT: CLPA_c08840(ctfB1) CLPA_c08850(atoD) CLPA_c15170(ctfA) CLPA_c15180(ctfB2)
CPAE: CPAST_c08840(ctfB1) CPAST_c08850(atoD) CPAST_c15170(ctfA) CPAST_c15180(ctfB2)
CSB: CLSA_c33620(ctfB) CLSA_c33630(ctfA)
CACE: CACET_c04240(ctfA) CACET_c04250(ctfB)
BPRL: CL2_15490
CDF: CD630_26770(scoA) CD630_26780(scoB)
PDC: CDIF630_02931(ctfA) CDIF630_02932(ctfB)
CDC: CD196_2518(ctfA) CD196_2519(ctfB)
CDL: CDR20291_2565(ctfA) CDR20291_2566(ctfB)
CST: CLOST_1123(atoD) CLOST_1124(atoA)
PTH: PTH_0268(AtoD) PTH_0269(AtoA)
AWO: Awo_c10970(ctfA)
TTE: TTE0720(AtoD) TTE0721(AtoA)
STED: SPTER_04980(atoD_1) SPTER_04990(atoA_1) SPTER_16100(atoD_2) SPTER_16110(atoA_2) SPTER_25710(atoA_3) SPTER_25720(atoD_3) SPTER_28440(atoA_4) SPTER_28450(atoD_4) SPTER_39590(atoD_5) SPTER_39600(atoA_5)
PFAC: PFJ30894_01339(atoA)
MBJ: KQ51_00858(ctfA) KQ51_00859(ctfB)
PGI: PG_1066(ctfA) PG_1075
PCRE: NCTC12858_00671(ctfA) NCTC12858_01322(ctfB)
PCAG: NCTC12856_01001(ctfA) NCTC12856_01010(ctfB)
BACC: BRDCF_p1066(ctfB) BRDCF_p1076(ctfA)
SDJ: NCTC13534_04619(scoA_2)
CACI: CLOAM0042(atoD) CLOAM0043(atoA)
MINF: MESINF_1592(atoD) MESINF_1593(atoA)
 » show all
Reference
1  [PMID:624727]
  Authors
Barker HA, Jeng IM, Neff N, Robertson JM, Tam FK, Hosaka S.
  Title
Butyryl-CoA:acetoacetate CoA-transferase from a lysine-fermenting Clostridium.
  Journal
J Biol Chem 253:1219-25 (1978)
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.9
IUBMB Enzyme Nomenclature: 2.8.3.9
ExPASy - ENZYME nomenclature database: 2.8.3.9
BRENDA, the Enzyme Database: 2.8.3.9
CAS: 66231-37-6
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