KEGG   ENZYME: 3.4.17.2
Entry
EC 3.4.17.2                 Enzyme                                 

Name
carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Preferential release of a C-terminal lysine or arginine amino acid
Comment
A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2
Orthology
K01291  carboxypeptidase B
Genes
HSA: 1360(CPB1)
PTR: 460763(CPB1)
PPS: 100992024(CPB1)
GGO: 101129511(CPB1)
PON: 100434248(CPB1)
NLE: 100606718(CPB1)
MCC: 712639(CPB1)
MCF: 102133877(CPB1)
CSAB: 103241512(CPB1)
RRO: 104671554(CPB1)
RBB: 108518296(CPB1)
CJC: 100406051(CPB1)
SBQ: 101037025(CPB1)
MMU: 76703(Cpb1)
MCAL: 110291636(Cpb1)
MPAH: 110320577(Cpb1)
RNO: 24271(Cpb1)
MUN: 110563021(Cpb1)
CGE: 100751091(Cpb1)
NGI: 103745993(Cpb1)
HGL: 101715608(Cpb1)
CCAN: 109682822(Cpb1)
OCU: 100358803(CPB1)
TUP: 102469136(CPB1)
CFA: 403512(CPB1)
VVP: 112932756(CPB1)
AML: 100471468(CPB1)
UMR: 103678088(CPB1)
UAH: 113254039(CPB1)
ORO: 101376449(CPB1)
ELK: 111147955
FCA: 101082684(CPB1)
PTG: 102968194(CPB1)
PPAD: 109260704(CPB1)
AJU: 106975221(CPB1)
BTA: 510039(CPB1)
BOM: 102265167(CPB1)
BIU: 109564536(CPB1)
BBUB: 102406620(CPB1)
CHX: 102184477(CPB1)
OAS: 101123433(CPB1)
SSC: 397341(CPB1)
CFR: 102508460(CPB1)
CDK: 105089516(CPB1)
BACU: 103002331(CPB1)
LVE: 103090379(CPB1)
OOR: 101269328(CPB1)
DLE: 111179171(CPB1)
PCAD: 102974801(CPB1)
ECB: 100058959(CPB1)
EPZ: 103558753(CPB1)
EAI: 106829437(CPB1)
MYB: 102244805(CPB1)
MYD: 102772230(CPB1)
MNA: 107544050(CPB1)
HAI: 109375861(CPB1)
DRO: 112300986(CPB1)
PALE: 102895857(CPB1)
RAY: 107513417(CPB1)
MJV: 108388604(CPB1)
LAV: 100658791(CPB1)
TMU: 101345894
MDO: 100012656(CPB1)
SHR: 100927003(CPB1)
PCW: 110204795(CPB1)
OAA: 100091762(CPB1)
GGA: 424888(CPB1)
MGP: 100544821(CPB1)
CJO: 107318162(CPB1)
NMEL: 110398295(CPB1)
APLA: 101797837
ACYG: 106036191
TGU: 100222062(CPB1)
LSR: 110473919(CPB1)
SCAN: 103815405(CPB1)
GFR: 102034134(CPB1)
FAB: 101812580(CPB1)
PHI: 102112631(CPB1)
PMAJ: 107209058
CCAE: 111933485(CPB1)
CCW: 104693471
ETL: 114057377
FPG: 101914576(CPB1)
FCH: 102052617(CPB1)
CLV: 102083429(CPB1)
EGZ: 104127123(CPB1)
NNI: 104015688(CPB1)
ACUN: 113483340(CPB1)
PADL: 103913837
AAM: 106485858(CPB1)
ASN: 102371682
AMJ: 102570215(CPB1)
PSS: 102455777
CMY: 102929825(CPB1)
CPIC: 101953934(CPB1)
ACS: 100562609(cpb1)
PVT: 110073048
PBI: 103064521
PMUR: 107284837(CPB1)
TSR: 106538569
PMUA: 114597863
GJA: 107124660(CPB1)
XLA: 108716366 495368(cpb1.S) 733324
XTR: 496994(cpb1)
DRE: 322412(cpb1)
SRX: 107739144(cpb1)
SANH: 107687549
SGH: 107588040(cpb1)
CCAR: 109051049(cpb1) 109051051
IPU: 108272506(cpb1)
PHYP: 113545433
AMEX: 103027518(cpb1)
EEE: 113584770
TRU: 101065526
LCO: 104937211(cpb1)
NCC: 104965401
MZE: 101480644(cpb1)
ONL: 100702694(cpb1)
OLA: 101169819(cpb1)
XMA: 102232269(cpb1)
XCO: 114136502(cpb1)
PRET: 103456548(cpb1)
CVG: 107096477(cpb1)
NFU: 107382805(cpb1)
KMR: 108230520(cpb1)
ALIM: 106513362(cpb1)
AOCE: 111579237(cpb1)
CSEM: 103377267(cpb1)
POV: 109629670(cpb1)
LCF: 108881689(cpb1)
SDU: 111237915(cpb1)
HCQ: 109519484
BPEC: 110170041(cpb1)
MALB: 109961496(cpb1)
SASA: 100196225(cbpb1)
OTW: 112227610
SALP: 112074819
ELS: 105026596
SFM: 108927668
PKI: 111840702
LCM: 102347915(CPB1)
CMK: 103184479
DER: 6544308
DPE: 6597184
DMN: 108165536
DWI: 6639599
MDE: 101895246
LCQ: 111684849
AME: 551327
BIM: 100746741
BTER: 100649475
CCAL: 108626036
OBB: 114871244
MDL: 103569002
TCA: 657015
TNL: 113499978
BTAB: 109035442
CLEC: 106663524
CRG: 105322408
NVE: 5519024
 » show all
Reference
1
  Authors
Folk, J.E.
  Title
Carboxypeptidase B (porcine pancreas).
  Journal
Methods Enzymol 19:504-508 (1970)
Reference
2  [PMID:1009123]
  Authors
Brodrick JW, Geokas MC, Largman C.
  Title
Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.
  Journal
Biochim Biophys Acta 452:468-81 (1976)
DOI:10.1016/0005-2744(76)90197-2
Reference
3  [PMID:40714]
  Authors
Butterworth J, Duncan JJ.
  Title
Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.
  Journal
Clin Chim Acta 97:39-43 (1979)
DOI:10.1016/0009-8981(79)90023-8
Reference
4  [PMID:6130442]
  Authors
Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD.
  Title
Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?
  Journal
Life Sci 31:1793-6 (1982)
DOI:10.1016/0024-3205(82)90212-0
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.2
IUBMB Enzyme Nomenclature: 3.4.17.2
ExPASy - ENZYME nomenclature database: 3.4.17.2
BRENDA, the Enzyme Database: 3.4.17.2
CAS: 9025-24-5
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