EC                Enzyme                                 

carboxypeptidase U;
arginine carboxypeptidase;
carboxypeptidase R;
plasma carboxypeptidase B (misleading, since the term carboxypeptidase B is used for other enzymes);
thrombin-activatable fibrinolysis inhibitor
Acting on peptide bonds (peptidases);
Release of C-terminal Arg and Lys from a polypeptide
Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U, with activity similar to that of the more stable lysine carboxypeptidase, except that no preference is shown for Lys over Arg. A zinc enzyme, in peptidase family M14 (carboxypeptidase A family)
EC created 1997
K01300  carboxypeptidase B2
HSA: 1361(CPB2)
PTR: 452582(CPB2)
PPS: 100993828(CPB2)
GGO: 101153798(CPB2)
PON: 100452501(CPB2)
NLE: 100582393(CPB2)
MCC: 703317(CPB2)
MCF: 102132600(CPB2)
CSAB: 103214382(CPB2)
RRO: 104658149(CPB2)
RBB: 108528946(CPB2)
CJC: 100411115(CPB2)
SBQ: 101041667(CPB2)
MMU: 56373(Cpb2)
MCAL: 110309374(Cpb2)
MPAH: 110325644(Cpb2)
RNO: 113936(Cpb2)
MUN: 110547470(Cpb2)
CGE: 100754304(Cpb2)
NGI: 103726752(Cpb2)
HGL: 101712343(Cpb2)
CCAN: 109698557(Cpb2)
OCU: 100341346(CPB2)
TUP: 102473098(CPB2)
CFA: 608910(CPB2)
VVP: 112933941(CPB2)
AML: 100482734(CPB2)
UMR: 103677685(CPB2)
UAH: 113251347(CPB2)
ORO: 101370239(CPB2)
ELK: 111147094
FCA: 101082116(CPB2)
PTG: 102952076(CPB2)
PPAD: 109265929(CPB2)
AJU: 106972009(CPB2)
BTA: 508222(CPB2)
BOM: 102285531(CPB2)
BIU: 109566696(CPB2)
BBUB: 102390937(CPB2)
CHX: 102181135(CPB2)
OAS: 101112329(CPB2)
SSC: 100155038(CPB2)
CFR: 102509764(CPB2)
CDK: 105089749(CPB2)
BACU: 103010017(CPB2)
LVE: 103075780(CPB2)
OOR: 101269719(CPB2)
DLE: 111175334(CPB2)
PCAD: 102985818(CPB2)
ECB: 100058534(CPB2)
EPZ: 103548935(CPB2)
EAI: 106829669(CPB2)
MYB: 102250791(CPB2)
MYD: 102755974(CPB2)
MNA: 107542259(CPB2)
HAI: 109391288(CPB2)
DRO: 112310676(CPB2)
PALE: 102878653(CPB2)
RAY: 107505990(CPB2)
MJV: 108407588(CPB2)
MDO: 100016398(CPB2)
SHR: 100928968(CPB2)
PCW: 110197346(CPB2)
OAA: 100083738(CPB2)
GGA: 418851(CPB2)
MGP: 100545409(CPB2)
CJO: 107308136(CPB2)
NMEL: 110387568(CPB2)
APLA: 101791007(CPB2)
ACYG: 106035057(CPB2)
TGU: 100229153(CPB2)
LSR: 110469572(CPB2)
SCAN: 103827416(CPB2)
GFR: 102041508(CPB2)
FAB: 101808771(CPB2)
PHI: 102107395(CPB2)
PMAJ: 107199992(CPB2)
CCAE: 111937540(CPB2)
CCW: 104689980(CPB2)
ETL: 114059887(CPB2)
FPG: 101919154(CPB2)
FCH: 102052809(CPB2)
CLV: 102085489(CPB2)
EGZ: 104131617(CPB2)
NNI: 104010961(CPB2)
ACUN: 113481749(CPB2)
PADL: 103915914(CPB2)
AAM: 106489197(CPB2)
ASN: 102376487(CPB2)
AMJ: 102562517(CPB2)
PSS: 102448472(CPB2)
CMY: 102946625(CPB2)
CPIC: 101933938(CPB2)
ACS: 100567959(cpb2)
PVT: 110076120(CPB2)
PBI: 103051972(CPB2)
PMUR: 107289863(CPB2)
PMUA: 114593624(CPB2)
GJA: 107110254(CPB2)
XLA: 108708528(cpb2.L) 108709798(cpb2.S)
XTR: 595005(cpb2)
NPR: 108794281(CPB2)
DRE: 100000935(cpb2)
SRX: 107707839(cpb2)
SANH: 107654270(cpb2)
SGH: 107588824(cpb2)
CCAR: 109067316(cpb2)
IPU: 108258492(cpb2)
PHYP: 113537361(cpb2)
AMEX: 103039184(cpb2)
EEE: 113585022(cpb2)
TRU: 101063870(cpb2)
LCO: 104937555(cpb2)
NCC: 104941379
ONL: 100699903
OLA: 101175299(cpb2)
XMA: 102234292(cpb2)
XCO: 114138216(cpb2)
PRET: 103475539(cpo)
CVG: 107093726(cpb2)
NFU: 107381108(cpb2)
KMR: 108246710(cpb2)
ALIM: 106529640(cpb2)
AOCE: 111580792(cpb2)
CSEM: 103389881(cpb2)
POV: 109643485
LCF: 108872994(cpb2)
SDU: 111238723(cpb2)
SLAL: 111644417(cpb2)
HCQ: 109520860(cpb2)
BPEC: 110168983(cpb2)
SASA: 106574315(cpb2) 106575090(cpo)
SALP: 111953182 111953547(cpb2)
ELS: 105023706(cpo)
PKI: 111860687
LCM: 102355283(CPB2)
CMK: 103177537(cpb2)
RTP: 109917215
AAG: 5572629
MDL: 103577483
EPA: 110245430
SPIS: 111335355
 » show all
1  [PMID:1939207]
Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D.
Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.
J Biol Chem 266:21833-8 (1991)
2  [PMID:8130654]
Shinohara T, Sakurada C, Suzuki T, Takeuchi O, Campbell W, Ikeda S, Okada N, Okada H.
Pro-carboxypeptidase R cleaves bradykinin following activation.
Int Arch Allergy Immunol 103:400-4 (1994)
3  [PMID:8195249]
Wang W, Hendriks DF, Scharpe SS.
Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen.
J Biol Chem 269:15937-44 (1994)
4  [PMID:7727441]
Tan AK, Eaton DL.
Activation and characterization of procarboxypeptidase B from human plasma.
Biochemistry 34:5811-6 (1995)
5  [PMID:8916945]
Broze GJ Jr, Higuchi DA.
Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma.
Blood 88:3815-23 (1996)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 156621-18-0

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