| Entry |
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| Name |
t-plasminogen activator;
tissue plasminogen activator;
plasminogen activator, tissue-type;
tissue-type plasminogen activator;
tPA;
t-PA
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Specific cleavage of Arg!Val bond in plasminogen to form plasmin
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| Comment |
A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC 3.4.21.31 and EC 3.4.99.26
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| History |
EC 3.4.21.68 created 1972 as EC 3.4.99.26, transferred 1978 as EC 3.4.21.31, part transferred 1992 to EC 3.4.21.68
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| Orthology |
| K01343 | tissue plasminogen activator |
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| Genes |
» show all
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| Reference |
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| Authors |
Pennica D, Holmes WE, Kohr WJ, Harkins RN, Vehar GA, Ward CA, Bennett WF, Yelverton E, Seeburg PH, Heyneker HL, Goeddel DV, Collen D |
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| Title |
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Loskutoff DJ, Schleef RR. |
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| Title |
Plasminogen activators and their inhibitors. |
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| Journal |
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| Reference |
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| Authors |
Petersen LC, Johannessen M, Foster D, Kumar A, Mulvihill E. |
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| Title |
The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage. |
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| Journal |
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| Reference |
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| Authors |
Verheijen JH. |
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| Title |
Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma. |
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| Journal |
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| Reference |
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| Authors |
Gerard RD, Meidell RS. |
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| Title |
Regulation of tissue plasminogen activator expression. |
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| Journal |
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| Reference |
6 |
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| Authors |
Collen, D., Lijnen, H. R. and Verstraete, M. |
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| Title |
The fibrinolytic system and its disorders. |
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| Journal |
In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.), Blood: Principles and Practice of Hematology, 2nd ed., J.B.Lippincott Company, Philadelphia, 1990 |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.68 |
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| LinkDB |
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