KEGG ENZYME: 3.5.4.29

ENZYME: 3.5.4.29

Entry

EC 3.5.4.29                 Enzyme

Name

GTP cyclohydrolase IIa

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines

Sysname

GTP 8,9-hydrolase (phosphate-forming)

Reaction(IUBMB)

GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate [RN:R07306]

Reaction(KEGG)

R07306

Substrate

GTP [CPD:C00044];
H2O [CPD:C00001]

Product

2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C15563];
phosphate [CPD:C00009]

Comment

Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N7-methylguanosine 5'-triphosphate or inosine 5'-triphosphate. Xanthosine 5'-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC 3.5.4.25), this enzyme does not release formate, but does hydrolyse the diphosphate from GTP to phosphate.

History

EC 3.5.4.29 created 2003, modified 2011

Pathway

ec00740

Riboflavin metabolism

ec01100

Metabolic pathways

Orthology

K08096

GTP cyclohydrolase IIa

Genes

ABUT:

Ami103574_11595

MJA:

MJ_0145

MFE:	Mefer_0498

MVU:	Metvu_1460

MFS:	MFS40622_0137

MIF:	Metin_0291

MJH:	JH146_0012

MESG:

MLAUSG7_0148(gch)

MESA:

MLASG1_1327(gch)

MIG:	Metig_0265

MMP:	MMP0405(gch3)

MMQ:	MmarC5_1233

MMX:	MmarC6_0505

MMZ:	MmarC7_1403

MMD:

GYY_02095

MMAK:

MMKA1_04240(gch3)

MMAO:

MMOS7_04200(gch3)

MMAD:

MMJJ_06320

MAE:

Maeo_0818

MVN:	Mevan_1393

MVO:

Mvol_1650

MOK:	Metok_0352

METF:

CFE53_05915

MTH:

MTH_1017

MMG:	MTBMA_c13990(gch3)

MWO:	MWSIV6_1403(gch3)

MTEE:

MTTB_04070

METC:

MTCT_0925

METE:

tca_00978

METZ:

METMT2_1043

METK:

FVF72_06525

MTHM:

FZP57_06705

METJ:

FZP68_03955

MST:	Msp_1404(gch3)

METB:

AW729_08500

MEIS:

PXD04_00065

MRU:	mru_1845(arfA)

MSI:

Msm_0973

MEB:	Abm4_1486(arfA)

MMIL:

sm9_1936(arfA)

MEYE:

TL18_09135

MOL:

YLM1_1302

MARO:

MarbSA_16670

METV:

K4897_06610

MEL:	Metbo_2437

MEW:	MSWAN_0205

METH:

MBMB1_0199(gch3)

MFC:	BRM9_2101(arfA)

MFI:	DSM1535_1580(gch3)

MCUB:

MCBB_0214(gch3)

MSUB:

BK009_10790

METN:

BK008_06430

METT:

CIT01_02825

METO:

CIT02_06020

MEME:

HYG87_04420

MFEG:

GCM10025860_10180

MEER:

NKF70_07680

MFV:

Mfer_0318

HAL:	VNG_1011C VNG_1021C

HSL:	OE_2472F(gch3a) OE_2492F(gch3b)

HANR:

LJ422_04150 LJ422_04190

HDL:	HALDL1_11210

HHB:	Hhub_2223(gch3)

HAGS:

JT689_05390 JT689_05430

HABO:

JRZ79_03890 JRZ79_03930

HNO:	LT974_06010

HLU:	LT972_07135

HANX:

ABSL23_10880

HALH:

HTSR_0917

HHSR:

HSR6_0931(gch)

HSU:	HLASF_1555(gch)

HSF:	HLASA_1542(gch)

HAHS:

HSRCO_1787(gch31)

SALR:

FQU85_08800

HALR:

EFA46_008365

HJE:	HacjB3_15030

HDO:	MUK72_04340 MUK72_14300

HALX:

M0R89_18045

HAXZ:

M0R88_18385

HAYC:

NGM10_00040

HAXY:

NGM07_04570

SALI:

L593_10970

SAIM:

K0C01_07415 K0C01_11305

HARA:

AArcS_0056(gch31) AArcS_1434(gch312)

HMA:

rrnAC0115

HHI:

HAH_0868

HHN:	HISP_04485

HAB:	SG26_12185

HTA:	BVU17_04250

HALJ:

G9465_17470

HSIN:

KDQ40_09160

NPH:	NP_4142A(arfA)

NMO:	Nmlp_2421(gch3)

NHO:	HWV23_09295 HWV23_14935

NSAL:

HWV07_19590

HUT:

Huta_1998

HMU:

Hmuk_2633

HALZ:

E5139_00445

HALL:

LC1Hm_1978(gch3)

HAZP:

GBQ70_00445

HALI:

BV210_09450 BV210_14835

HSN:	DV733_08805 DV733_11860

HDS:	HSR122_0414(gch31) HSR122_0948(gch312)

HRR:	HZS55_16335

HPEL:

HZS54_19100

HLT:	I7X12_14885 I7X12_19560

HARC:

HARCEL1_06920

SSAI:

N0B31_07175 N0B31_14970

HAAD:

MW046_04520 MW046_05180

HWA:	HQ_2427A(arfA)

HWC:	Hqrw_2717(arfA)

HVO:	HVO_1284(gch3)

HALE:

G3A49_09620

HLN:	SVXHx_1244(gch3)

HME:

HFX_1350

HGI:	ABY42_06270

HLS:	KU306_11145

HBO:	Hbor_19420

HAQ:	DU484_08965

HAJ:	DU500_09215

HAER:

DU502_06285

HRA:	EI982_06960

HLM:	DV707_08865

HALM:

FCF25_13050

HLA:

Hlac_2188

HALP:

DOS48_10475

HALB:

EKH57_07645 EKH57_14865

HEZZ:

EO776_11305

HALQ:

Hrr1229_011200

HSAI:

HPS36_10190

HAZZ:

KI388_08310 KI388_09725

SRUB:

C2R22_08140

HAE:	halTADL_2942

HALN:

B4589_000910

HALG:

HUG10_05900

HALU:

HUG12_11030

HMP:	K6T50_03195

HRE:	K6T36_03080

HRM:	K6T25_12245

HACB:

Hbl1158_11005

HDF:	AArcSl_0927(gch3) AArcSl_2529(gch32)

HAH:	Halar_1491

HTU:

Htur_1598

HSAL:

JMJ58_00645

HAKZ:

J0X25_14815

NMG:	Nmag_3329(gch3)

HXA:	Halxa_3150

NAT:	NJ7G_0632 NJ7G_3305

NPE:	Natpe_2601

NVR:	FEJ81_11955

NPL:	FGF80_01095 FGF80_10980

NAY:	HYG81_14765

HALY:

HYG82_14370 HYG82_17370

HJT:	DVR14_02985

HLO:	J0X27_02160

NGE:	Natgr_3410

HRU:	Halru_1555

SAWL:

NGM29_08810

HALV:

NGM15_00975

NOU:	Natoc_1516

HLR:	HALLA_10870

HLC:	CHINAEXTREME16115

NAJ:	B1756_02415

NAG:	AArcMg_1652 AArcMg_4012

NAN:	AArc1_1987 AArc1_5063

NARA:

QQ977_00705

NBG:	DV706_13020

NAS:	GCU68_13760

HDA:	BB347_04080

APE:	APE_1365.1

ACJ:

ACAM_0863

SMR:

Smar_0486

SHC:	Shell_0316

IHO:

Igni_1352

IIS:

EYM_01970

PFM:	Pyrfu_1597

PDL:	Pyrde_2004

PABI:

PABY_20330

STO:

STK_03950

SOH:	D1869_01695

SJV:	SJAV_13870

SSO:

SSO0399

SOL:

Ssol_1377

SSOA:

SULA_1423

SSOL:

SULB_1424

SSOF:

SULC_1422

SSHI:

J5U23_03036

SCAS:

SACC_06280

SIS:	LS215_1832

SIA:	M1425_1704

SIM:	M1627_1820

SID:

M164_1751

SIY:	YG5714_1820

SIN:	YN1551_1106

SII:

LD85_1961

SIH:

SiH_1679

SIR:

SiRe_1600

SIC:

SiL_1592

SULA:

BFU36_03810

SULE:

GFS03_09565

SAI:

Saci_0819

SULO:

GFS33_01380

SULL:

EWF20_03165

MSE:

Msed_0049

MEMJ:

MJ1HA_0051

MCN:

Mcup_0048

MHK:	DFR87_07225

MPRU:

DFR88_06440

MTEN:

GWK48_04940

MJN:	MjAS7_0636

AHO:

Ahos_0727

AMAN:

B6F84_07075

ABRI:

DFR85_07865

ASUL:

DFR86_06135

AAMB:

D1866_11425

ACIH:

HS5_21020

SACD:

HS1genome_0323

SAZO:

D1868_02455

CSTY:

KN1_19780

STEP:

IC006_1494

SMET:

RQ359_000442

SAHS:

HS7_02920

PAI:

PAE2984

PIS:

Pisl_0384

PCL:

Pcal_1123

PAS:

Pars_1351

PYR:

P186_1548

POG:

Pogu_0863

TNE:

Tneu_1743

PYW:	PYWP30_01862

TTN:

TTX_1009

TUZ:

TUZN_0675

VDI:

Vdis_0343

VMO:

VMUT_1288

ASC:

ASAC_0813

ACIA:

SE86_05725

CLG:	Calag_0338

NMR:

Nmar_1614

NIR:	NSED_08735

NKR:	NKOR_08785

NID:	NPIRD3C_0439(gch)

NIN:	NADRNF5_0270(gch)

NIW:	Nisw_05820

NCL:	C5F47_08460

NOX:	C5F49_08345

NUE:	C5F50_07110 C5F50_11725

NIP:	NsoK4_00190

NZT:	NZOSNM25_000170

NCT:	NMSP_1555(gch3)

NGA:	Ngar_c32640(gch3)

NVN:	NVIE_021890(gch)

NEV:

NTE_03547

TAA:	NMY3_03741

NFN:	NFRAN_1030(gch)

NCV:	NCAV_0049(gch)

NDV:	NDEV_1968(gch)

CSY:	CENSYa_1757

NBV:

T478_1328

TAH:	SU86_005140

NIU:	DSQ19_00910

NCK:	QVH35_04475

CCAI:

NAS2_0573

» show all

Reference

1 [PMID:12475257]

Authors

Graham DE, Xu H, White RH

Title

A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates.

Journal

Biochemistry 41:15074-84 (2002)
DOI:10.1021/bi0268798

Sequence

[mja:MJ_0145]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.4.29

IUBMB Enzyme Nomenclature:

3.5.4.29

ExPASy - ENZYME nomenclature database:

3.5.4.29

BRENDA, the Enzyme Database:

3.5.4.29

LinkDB

DBGET integrated database retrieval system