KEGG   ENZYME: 3.5.99.16
Entry
EC 3.5.99.16                Enzyme                                 
Name
deacetylipecoside synthase;
deacetylipecoside dopamine-lyase;
deacetylipecoside dopamine-lyase (secologanin-forming)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
Sysname
deacetylipecoside dopamine-hydroyase (secologanin-forming)
Reaction(IUBMB)
deacetylipecoside + H2O = dopamine + secologanin [RN:R05749]
Reaction(KEGG)
R05749
Substrate
deacetylipecoside [CPD:C07307];
H2O [CPD:C00001]
Product
dopamine [CPD:C03758];
secologanin [CPD:C01852]
Comment
The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 3.5.99.15, deacetylisoipecoside synthase. The product is rapidly converted to demethylalangiside.
History
EC 3.5.99.16 created 2000 as EC 4.3.3.4, transferred 2024 to EC 3.5.99.16
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
Reference
1
  Authors
DeEknamkul, W., Ounaroon, A., Tanahashi, T., Kutchan, T. and Zenk, M.H.
  Title
Enzymatic condensation of dopamine and secologanin by cell-free extracts of Alangium lamarckii.
  Journal
Phytochemistry 45:477-484 (1997)
Reference
2  [PMID:11065292]
  Authors
De-Eknamkul W, Suttipanta N, Kutchan TM.
  Title
Purification and characterization of deacetylipecoside synthase from Alangium lamarckii Thw.
  Journal
Phytochemistry 55:177-81 (2000)
DOI:10.1016/s0031-9422(00)00260-0
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.16
IUBMB Enzyme Nomenclature: 3.5.99.16
ExPASy - ENZYME nomenclature database: 3.5.99.16
BRENDA, the Enzyme Database: 3.5.99.16
CAS: 192827-93-3
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