KEGG   ENZYME: 3.8.1.5
Entry
EC 3.8.1.5                  Enzyme                                 

Name
haloalkane dehalogenase;
1-chlorohexane halidohydrolase;
1-haloalkane dehalogenase
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
Sysname
1-haloalkane halidohydrolase
Reaction(IUBMB)
1-haloalkane + H2O = a primary alcohol + halide [RN:R02337]
Reaction(KEGG)
Substrate
1-haloalkane [CPD:C01872];
H2O [CPD:C00001]
Product
primary alcohol [CPD:C00226];
halide [CPD:C00462]
Comment
Acts on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds.
History
EC 3.8.1.5 created 1989
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00625  Chloroalkane and chloroalkene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01563  haloalkane dehalogenase
Genes
KMI: VW41_10305
SOF: NCTC11214_01991(dhaA)
LAB: LA76x_0649(dhaA)
LAQ: GLA29479_2842(linB)
LMB: C9I47_2934
DJI: CH75_13575
VOW: A9237_20330
VSH: BSZ05_17590
PCR: Pcryo_1253
PSO: PSYCG_06610
SSE: Ssed_1777
SPSW: Sps_02009
PAT: Patl_1915
PSM: PSM_B0300
PART: PARC_b0374(dhaA)
PTD: PTET_b0384(dhaA)
MAQ: Maqu_2428
MHC: MARHY0818(dhmA)
MAD: HP15_2669 HP15_590(dhmA)
MBS: MRBBS_3794(mhpC)
MARJ: MARI_21190(dhmA1)
AMAL: I607_08090
AMAE: I876_08355
AMAO: I634_08460
AMAD: I636_08890
AMAI: I635_09160
AMAG: I533_08400
AMAC: MASE_07990
AAUS: EP12_08760
GNI: GNIT_0188
GPS: C427_1826
MICT: FIU95_06845(dhlA) FIU95_07325(dhmA)
CBU: CBU_1225
CBD: CBUD_1310
CBG: CbuG_0785
CBC: CbuK_1085
ALG: AQULUS_10690(dhaA)
ASIP: AQUSIP_11620(dhaAF_1) AQUSIP_24890(dhaAF_2)
GAI: IMCC3135_16825(linB) IMCC3135_16970(dhaA_1) IMCC3135_16985(dhmA2) IMCC3135_17030(dhaA_2) IMCC3135_28350(dhaA_3)
HCH: HCH_05560
ABO: ABO_2415(dhmA)
OAI: OLEAN_C34210(dhmA)
SVA: SVA_0114
CHIZ: HQ393_06475(tadA)
CFON: HZU75_15270(tadA)
BCEN: DM39_1977(dhaA) DM39_2021(dhaA)
RFR: Rfer_2286
RHF: EUB48_10290(tadA)
RHG: EXZ61_09440(tadA)
POL: Bpro_2447
PNA: Pnap_1997
POO: F7R28_14115(tadA)
AAV: Aave_3082
AJS: Ajs_2282
AAA: Acav_2201
ACRA: BSY15_3011(dhlA)
ACIO: EAG14_08755(tadA)
VEI: Veis_2620
DAC: Daci_4809
CTES: O987_10940
RTA: Rta_19770
LIM: L103DPR2_01777(dhlA) L103DPR2_02525(dhmA)
LIH: L63ED372_01363(dhlA)
HYR: BSY239_1724(dhlA)
HYB: Q5W_10125
HYC: E5678_05560(tadA)
HPSE: HPF_11235(dhlA)
HYN: F9K07_15285(tadA)
DIH: G7047_12265(tadA)
CBAA: SRAA_1219
CBAB: SMCB_1084
XYK: GT347_26605(tadA)
DOE: DENOEST_2870(dhmA)
GEO: Geob_2043(linB)
DALK: DSCA_48290(dhmA1)
CCX: COCOR_03107(dha) COCOR_05952(dhmA2)
SCL: sce2168(dha)
HOH: Hoch_1443
MLO: mlr5354
MHUA: MCHK_6388
PLA: Plav_1611
ATU: Atu6064(dha)
RLE: pRL110536
RLG: Rleg_6597
NEN: NCHU2750_56020(dha)
BJA: blr1087
AZC: AZC_1390
RBM: TEF_16230
CCR: CC_1175
CAK: Caul_2671
CSE: Cseg_2706
PZU: PHZ_c2250(dhlA)
JAN: Jann_2620
MALU: KU6B_18090
HNE: HNE_0985(dhlA)
SPHK: SKP52_04710(dhmA)
SPHP: LH20_01540
SGI: SGRAN_1300(dhmA)
SPHU: SPPYR_2635(dhmA)
SSAN: NX02_14860
SPKC: KC8_11355
SJP: SJA_C1-19590(linB)
SINB: SIDU_17345
BLAS: BSY18_1050 BSY18_475(dhlA)
SMIC: SmB9_00360(dhaA)
ELI: ELI_03475
ERF: FIU90_10435(dhmA)
ADO: A6F68_01339(dhmA) A6F68_02625(dhaAF)
TMO: TMO_0441(dhlA)
PMW: B2K_22145
SAY: TPY_0500(dhaA)
MTU: Rv1833c Rv2296 Rv2579(dhaA)
MTC: MT1881 MT2353 MT2656(linB)
MTUH: I917_18205
MCQ: BN44_40093 BN44_50246(dhmA) BN44_60039(dhaA)
MCV: BN43_30971 BN43_31543(dhmA) BN43_40253(dhaA)
MCX: BN42_40214(dhmA) BN42_40560(dhaA)
MCZ: BN45_50096 BN45_50630(dhmA) BN45_50969(dhaA)
MLP: MLM_1870
MUL: MUL_3052 MUL_3979(dhaA)
MMC: Mmcs_4949
MKM: Mkms_5037
MJL: Mjls_5330
MLI: MULP_00098(dhaA_1) MULP_04277(dhaA) MULP_04652
MSHG: MSG_00594(dhmA) MSG_03236(dhmA1) MSG_04148
MFJ: MFLOJ_06360(dhmA2) MFLOJ_07610 MFLOJ_58400(dhmA1)
MXE: MYXE_03100 MYXE_25740(dhmA2)
MSG: MSMEI_6149(dhmA1) MSMEI_6656(dhaA)
MVA: Mvan_2384
MTHN: 4412656_02462(dhaA_2)
MDU: MDUV_21770(dhaA)
MCHT: MCHIJ_23020(dhmA2)
MSTE: MSTE_02828 MSTE_02831(dhaA)
MTER: 4434518_03970(dhmA)
MMIN: MMIN_04590(dhmA2) MMIN_14740
ASD: AS9A_0181
MKR: MKOR_23800(dhmA1)
NFA: NFA_26230
NNO: NONO_c01140(dhmA1) NONO_c48280(dhmA2) NONO_c72790
NAD: NCTC11293_00425(dhaA_1)
REY: O5Y_05410
GPO: GPOL_c45710(dhmA)
GRU: GCWB2_12385(dhaA2)
TPR: Tpau_2475
STRE: GZL_08308
STRM: M444_06220
SNR: SNOUR_37320(dhmA2)
MTS: MTES_0866
CFI: Celf_3754
NDK: I601_0825(dhmA_1)
KFL: Kfla_1983
GOB: Gobs_0257
BSD: BLASA_0113(dhmA) BLASA_0238(dhaA)
MMAR: MODMU_0271(dhaA)
SACC: EYD13_00725(dhmA)
AMD: AMED_0191(dhaA) AMED_6398(dhaA)
AMM: AMES_0187(dhaA) AMES_6306(dhaA)
AMZ: B737_0188(dhaA) B737_6306(dhaA)
AOI: AORI_0188(dhaA) AORI_2120(dhaA)
AJA: AJAP_01000(dhmA) AJAP_28925(dhmA2)
AMQ: AMETH_0214(dhaA) AMETH_5325(dhaA)
AMYY: YIM_00990(dhmA1) YIM_24780(dhaA2) YIM_29890(dhaA3)
PAUT: Pdca_50730(dhaA)
ACTI: UA75_12695
ACAD: UA74_12615
MIL: ML5_4654
CAI: Caci_6469
AYM: YM304_07150(dhaA) YM304_31380(dhmA)
VBL: L21SP4_02395(dhmA_3)
ABAS: ACPOL_2872
ABAC: LuPra_02086(dhaA)
TMAR: MARIT_0441(dhaA)
HME: HFX_2390(mhpC)
SALI: L593_05270
LOKI: Lokiarch_30800(dhlA)
 » show all
Reference
1  [PMID:4019411]
  Authors
Keuning S, Janssen DB, Witholt B.
  Title
Purification and characterization of hydrolytic haloalkane dehalogenase from Xanthobacter autotrophicus GJ10.
  Journal
J Bacteriol 163:635-9 (1985)
DOI:10.1128/JB.163.2.635-639.1985
  Sequence
Reference
2  [PMID:3667524]
  Authors
Scholtz R, Leisinger T, Suter F, Cook AM.
  Title
Characterization of 1-chlorohexane halidohydrolase, a dehalogenase of wide substrate range from an Arthrobacter sp.
  Journal
J Bacteriol 169:5016-21 (1987)
DOI:10.1128/JB.169.11.5016-5021.1987
Reference
3  [PMID:3624201]
  Authors
Yokota T, Omori T, Kodama T.
  Title
Purification and properties of haloalkane dehalogenase from Corynebacterium sp. strain m15-3.
  Journal
J Bacteriol 169:4049-54 (1987)
DOI:10.1128/JB.169.9.4049-4054.1987
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.5
IUBMB Enzyme Nomenclature: 3.8.1.5
ExPASy - ENZYME nomenclature database: 3.8.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.5
BRENDA, the Enzyme Database: 3.8.1.5
CAS: 95990-29-7
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