KEGG   ENZYME: 4.1.1.106
Entry
EC 4.1.1.106                Enzyme                                 

Name
fatty acid photodecarboxylase;
FAP (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
fatty acid carboxy-lyase (light-dependent, alkane-forming)
Reaction(IUBMB)
a long-chain fatty acid + hnu = a long-chain alkane + CO2 [RN:R11915]
Reaction(KEGG)
R11915
Substrate
long-chain fatty acid [CPD:C00638];
hnu [CPD:C00205]
Product
long-chain alkane [CPD:C21763];
CO2 [CPD:C00011]
Comment
This algal enzyme, characterized from the green algae Chlorella variabilis and Chlamydomonas reinhardtii, is dependent on blue light, which photooxidizes its FAD cofactor. The enzyme acts on fatty acids in the range of C12 to C22, with a higher efficiency for C16 to C17 chains, and forms an alkane product that is one carbon shorter than the substrate. The enzyme can also act on unsaturated fatty acids, forming the respective alkenes, but does not generate a new double bond.
History
EC 4.1.1.106 created 2017
Orthology
K22464  fatty acid photodecarboxylase
Genes
CRE: CHLREDRAFT_140509
VCN: VOLCADRAFT_103673
CSL: COCSUDRAFT_60347
CVR: CHLNCDRAFT_28598
Reference
1  [PMID:28860382]
  Authors
Sorigue D, Legeret B, Cuine S, Blangy S, Moulin S, Billon E, Richaud P, Brugiere S, Coute Y, Nurizzo D, Muller P, Brettel K, Pignol D, Arnoux P, Li-Beisson Y, Peltier G, Beisson F
  Title
An algal photoenzyme converts fatty acids to hydrocarbons.
  Journal
Science 357:903-907 (2017)
DOI:10.1126/science.aan6349
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.106
IUBMB Enzyme Nomenclature: 4.1.1.106
ExPASy - ENZYME nomenclature database: 4.1.1.106
BRENDA, the Enzyme Database: 4.1.1.106
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