KEGG ENZYME: 4.1.1.4

ENZYME: 4.1.1.4

Entry

EC 4.1.1.4 Enzyme

Name

acetoacetate decarboxylase;
acetoacetic acid decarboxylase;
acetoacetate carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

acetoacetate carboxy-lyase (acetone-forming)

Reaction(IUBMB)

acetoacetate + H+ = acetone + CO2 [RN:R01366]

Reaction(KEGG)

R01366

Substrate

acetoacetate [CPD:C00164];
H+ [CPD:C00080]

Product

acetone [CPD:C00207];
CO2 [CPD:C00011]

History

EC 4.1.1.4 created 1961

Pathway

ec00072

Synthesis and degradation of ketone bodies

ec00640

Propanoate metabolism

ec01100

Metabolic pathways

Orthology

K01574

acetoacetate decarboxylase

Genes

SOD:

Sant_2149

XBC:	ELE36_05380

DJA:	HY57_02905

DTX:	ATSB10_30600

DYE:	EO087_12185

DCS:	ISN74_00485

VHA:	VIBHAR_01634

VCA:	M892_04960

VNI:	VIBNI_A1549

PMAI:

CF386_02380

PAP:	PSPA7_3628

ABY:

ABAYE1742

ABN:

AB57_2158

ABB:	ABBFA_01610(adc)

ACAL:

BUM88_10390

ACD:	AOLE_08860

ADS:	FPL17_09310

MOS:	AXE82_10470

ZAL:	AZF00_04640

OSG:	BST96_08300 BST96_14785

HJA:	BST95_04415 BST95_09935

HALC:

EY643_12670 EY643_18075

ALG:	AQULUS_15330(adc)

ASIP:

AQUSIP_11420(adc)

LPN:

lpg0672

LPH:

LPV_0792

LPO:

LPO_0752

LPU:	LPE509_02541

LPM:	LP6_0655(adc)

LPF:

lpl0708

LPP:

lpp0728

LPC:	LPC_2621(adc)

LPA:	lpa_01052(adc)

LPE:

lp12_0680

LLO:	LLO_0619 LLO_1749

LFA:	LFA_2607(adc)

LHA:	LHA_0922(adc)

LOK:

Loa_02267

LCD:	clem_10470(adc)

LSH:	CAB17_07330 CAB17_13380

LLG:	44548918_01965(adc)

LIB:	E4T55_09670

LJR:	NCTC11533_02131(adc)

LCJ:	NCTC11976_01373(adc)

LWA:	SAMEA4504053_0998(adc)

LSS:	NCTC12082_00433(adc)

LADL:

NCTC12735_00965(adc)

TMC:	LMI_1009(adc)

MMOB:

F6R98_20790

FTQ:

RO31_1069

FTR:	NE061598_05330

FTL:

FTL_1279

FTH:	FTH_1252(adc)

FTS:

FTC:

FTV:

FTZ:

FTN:

FTX:

FTD:	AS84_1732 AS84_221(adc)

FTY:	CH70_1214 CH70_1602

FCF:	FNFX1_0817

FCN:	FN3523_0977

FHI:	FSC454_05175

FPH:

FPT:

FPI:

FPM:

FPX:

FPZ:

FPJ:

FRT:	F7308_1310

FRF:	LO80_01300

FRX:	F7310_04975

FRM:	BBG19_0835

FRC:

KX01_1314

FAD:	CDH04_04930

FMI:	F0R74_03580

FOO:	CGC45_04235

FGU:	SD28_05150

THIP:

N838_24315

GAI:	IMCC3135_28100(adc)

OME:	OLMES_2715

AEM:	CK911_01335

NBA:	CUN60_01510

CVI:

CV_3520

CVC:	BKX93_08355

CHRO:

CXB49_03930

CHRI:

DK842_02525

CHRB:

DK843_08005

CRZ:	D1345_14140

CHRM:

FYK34_12015

CHAE:

CH06BL_29750(adc)

AMAH:

DLM_2798

AQS:	DKK66_13055

RSO:	RSp1058(adc)

RSL:	RPSI07_mp1091(adc)

RSN:	RSPO_m01367(adc)

RSM:	CMR15_mp20167(adc)

RSE:

F504_4138

RSY:	RSUY_42550

RPI:

Rpic_4271

RPF:	Rpic12D_4381

RMN:	TK49_22010

RIN:	ACS15_4215

RPU:	CDC45_22940

CUH:	BJN34_28440

CBW:	RR42_m0247

CPAU:

EHF44_02675

BMA:	BMAA0018(adc)

BMV:	BMASAVP1_1168(adc)

BML:	BMA10229_1447(adc)

BMN:	BMA10247_A0022(adc)

BMAL:

BMAE:

BMAQ:

BMAI:

BMAF:

BMAZ:

BMAB:

BPS:	BPSS0018(adc)

BPM:	BURPS1710b_A1525

BPL:	BURPS1106A_A0022

BPD:	BURPS668_A0024

BPSE:

BPSM:

BPSU:

BPSD:

BPZ:	BP1026B_II0019(adc)

BPQ:	BPC006_II0021

BPK:

BPSH:

BPSA:

BPSO:

BUT:

BTE:	BTH_II0020

BTQ:

BTJ:

BTZ:

BTD:

BTV:

BTHE:

BTHM:

BTHA:

BTHL:

BOK:

BOC:

BUU:	WS70_17385

BVI:	Bcep1808_3777 Bcep1808_4583

BVE:	AK36_4334 AK36_4932

BUR:	Bcep18194_B1397 Bcep18194_B3166

BCN:

Bcen_5145

BCH:	Bcen2424_5714

BCM:	Bcenmc03_4525

BCJ:	BCAM0023(adc)

BCEN:

DM39_4984

BCEW:

DM40_3428

BCEO:

I35_4023(adc)

BAM:

Bamb_4983

BAC:	BamMC406_3126 BamMC406_5563

BMU:

BMK:

BMUL:

BCT:

BCED:

BCEP:

APZ15_24935 APZ15_36175

BDL:

AK34_4944

BPYR:

ABD05_21330 ABD05_30610

BCON:

NL30_25410

BUB:

BW23_4035

BDF:	WI26_15450

BLAT:

WK25_15965 WK25_19575

BTEI:

BSEM:

BPSL:

BMEC:

BSTG:

WT74_20460 WT74_24130

BSTL:

BBJ41_28100

BGL:	bglu_2g00230

BGU:

KS03_3618

BGD:	bgla_2g00270

BGO:

BM43_6753

BYI:	BYI23_D003570

BUK:	MYA_3434 MYA_4654

BUE:	BRPE67_DCDS05300

BUL:

BW21_4268

BUQ:	AC233_25510

BGP:	BGL_2c00230

BPLA:

bpln_2g00230

BUD:	AQ610_19580

BXE:	Bxe_A2916 Bxe_A3367

BXB:	DR64_1067 DR64_598

BPH:	Bphy_3919 Bphy_5526

BPY:	Bphyt_1567 Bphyt_2412

BUZ:	AYM40_23020 AYM40_28035

BFN:

OI25_154

BCAI:

K788_0000336 K788_0005690

PARA:

BTO02_31245

PARB:

CJU94_17225

PHS:	C2L64_26230 C2L64_27150

PTER:

C2L65_22200 C2L65_28160

PGP:	CUJ91_30705

PTS:	CUJ90_25220

PCAF:

DSC91_006665

PMEG:

FNZ07_10510

PTRO:

G5S35_27335

PTX:	ABW99_09945

HYF:	DTO96_102460(adc)

BUO:	BRPE64_DCDS09330

BAV:	BAV0264(adc)

BTRM:

SAMEA390648701655(adc)

BBRO:

BAU06_24145

BFZ:	BAU07_19180

BOZ:	DBV39_10855

PUS:	CKA81_13060

RHY:	RD110_13955

RHF:	EUB48_06495

AAA:

Acav_3657

VPE:	Varpa_3667

VAA:	AX767_00600

VAM:	C4F17_03210

HYC:	E5678_14280

JAG:	GJA_1480(adc)

HHT:	F506_04135

HEE:	hmeg3_06130

CFU:	CFU_1420(adc)

CARE:

LT85_3349

CPRA:

CPter91_3559

GLC:	JQN73_14705

TIN:

Tint_0561

THI:	THI_0731(adc)

RDP:	RD2015_2872

FPHO:

SHINM1_016820(adc)

DAL:	Dalk_0253 Dalk_5186

DTI:	Desti_0617

RBT:	NOVO_06325(adc)

MLO:	mll5917 mlr2399 mlr3634

MLN:	A9174_07425 A9174_32420

MCI:	Mesci_1460

MOP:	Mesop_1502

MAM:	Mesau_01515

MAMO:

A6B35_01070

MESW:

A9K65_007490

MESM:

EJ066_12285

MESP:

C1M53_17115 C1M53_17410

MHUA:

MCHK_5016

MJR:	EB229_07635 EB229_33140

MERD:

EB233_07550 EB233_30785

PHT:	BLM14_18370

NIY:	FQ775_12400

SFD:	USDA257_c17320 USDA257_c17360

SIX:	BSY16_5136

RLE:	pRL90174(adc)

RLG:

Rleg_6203

RTR:	RTCIAT899_PC07610

RHL:	LPU83_pLPU83d0937

RHR:	CKA34_24375

RII:	FFM53_006555 FFM53_034345

KAI:	K32_06370(adc)

BJA:	bll7763(bll7763) blr3945(blr3945) blr7028(blr7028)

BJU:	BJ6T_16150 BJ6T_58910 BJ6T_62570

BJP:	RN69_07975 RN69_30325

BBT:	BBta_1411(adc)

BRC:	BCCGELA001_06320

BRAD:

BF49_0522 BF49_1107

BIC:	LMTR13_18410

BRK:	CWS35_01220 CWS35_27820

BOT:	CIT37_17685 CIT37_22400 CIT37_34260 CIT37_35815

BGQ:	X265_23275

BGZ:	XH91_31050

BARH:

WN72_21245

BVZ:	BRAD3257_2299(adc)

BOP:	AXW83_05225

BVV:	BHK69_03865

BOI:	BLM15_25975

BOF:	FQV39_15580 FQV39_29260

VGO:	GJW-30_1_03383(adc_1) GJW-30_1_03970(adc_2)

TRB:	HB776_20345 HB776_20960

XAU:

AZC:

SNO:

STAR:

LNE:	FZC33_29985

ANC:	GBB76_08680

APRA:

G3A50_05825

MNO:	Mnod_4592 Mnod_7618

MAQU:

Maq22A_2p40725 Maq22A_c24380(adc)

MEE:	DA075_16590

MTEA:

DK419_22800

MOC:	BB934_02595 BB934_11530 BB934_31395 BB934_36525

BID:	Bind_1938 Bind_2695

MSL:

Msil_2114

MTUN:

MTUNDRAET4_2027(adc)

MLG:	CWB41_08665

CHEL:

AL346_14825

HDN:

Hden_0804

HDT:	HYPDE_33703

HMC:	HYPMC_1385(adc)

RHZ:	RHPLAN_16330 RHPLAN_31430

MSC:

MBRY:

MHEY:

MPAR:

MTW:	CQW49_20700

MMED:

Mame_04573(adc)

PSIN:

CAK95_21710

NOH:	G5V57_06280

PSF:	PSE_4743(adc)

OCT:	FTO60_03710

PTP:	RCA23_c23280

THW:	BMG03_19400

PSEB:

EOK75_19330

NTD:	EGO55_03040

SPHK:

SKP52_08055(adc1)

SPHX:

SPHD:

SPHM:

SSAN:

SPKC:

SJP:	SJA_C1-05680(adc)

SUFL:

FIL70_04295

BLAS:

BSY18_3376 BSY18_3377

BFW:	B5J99_07755 B5J99_07760

SPHJ:

BSL82_17630

ACR:

Acry_0495

AMV:	ACMV_05700(adc)

ATI:	AL072_27465

NAO:	Y958_21525

HTQ:	FRZ44_16710(adc2) FRZ44_20890

HADH:

FRZ61_26150

PSTG:

E8M01_28145 E8M01_28150

BAY:	RBAM_030030

BAQ:	BACAU_3026(adc)

BYA:	BANAU_3191(adc)

BAMP:

B938_15370

BAML:

BAM5036_2915(adc)

BAMA:

RBAU_3134(adc)

BAMN:

BASU_2921(adc)

BAMB:

BAPNAU_3182(adc)

BAMT:

AJ82_16990

BAMY:

V529_32620

BMP:	NG74_03152(adc)

BQY:	MUS_3595(adc)

BAMI:

KSO_004145

BAMC:

U471_31140

BAMF:

U722_16140

BAE:	BATR1942_11245

BVM:	B9C48_15350

BACP:

SB24_13720

BACB:

OY17_18340

TAP:	GZ22_05505

VNE:	CFK40_04275 CFK40_04285

SCA:	SCA_2369(adc)

SSIF:

AL483_11335

SCV:	A4G25_08380

SCAR:

DWB96_00205

EXM:	U719_06385

EXU:	ESP131_08780

PPY:

PPE_01174

PPM:	PPSC2_06055(adc1) PPSC2_12620(adc3)

PPO:	PPM_1145(adc1) PPM_2419(adc3)

PPOL:

X809_06080

PPQ:	PPSQR21_012350(adc)

PPOY:

RE92_05830 RE92_24155

PTA:	HPL003_14115

PGM:	PGRAT_02175

POD:	PODO_04285

PAEN:

P40081_05090

PRI:	PRIO_0485(adc) PRIO_1671

PPEO:

ABE82_06170

PBV:	AR543_07805

PXL:	BS614_18985

PDH:	B9T62_37500

PKB:	B4V02_16110

PAIH:

ASL14_05605

PBAC:

HUB98_01770

RST:	ATY39_08040

LJE:	BUE77_06840

LCA:

LSEI_0716

LCZ:	LCAZH_0655

LCS:

LCBD_0791

LCE:

LC2W_0790

LCW:	BN194_07850

LCL:	LOCK919_0817

LPI:	LBPG_02782

LPAP:

LBPC_0634

LCB:	LCABL_07810

LCX:	LCA12A_1743

LRH:	LGG_00705(adc)

LRG:

LRHM_0682

LPJ:

JDM1_0071

LPT:	zj316_0277(adc)

LPS:	LPST_C0050

LPR:	LBP_cg0051

LPZ:

Lp16_0063

LPB:	SH83_00270

LPX:	ASU28_03095

LPG:	BB562_00270

LLE:	AYR59_02500

LFV:	LF543_00935

LSL:

LSL_0135

LSI:

HN6_00115

LSJ:

LSJ_0164

LCY:	LC20004_00610

LROS:

LROSL1_1927

WVR:	IE337_06635

CAC:	CA_P0165(adc)

CAE:	SMB_P163(adc)

CAY:	CEA_P0163(adc)

CBK:

CBE:

CBZ:

CBEI:

CSR:	Cspa_c56910(adc)

CPAS:

Clopa_1770

CPAT:

CLPA_c15190(adc)

CPAE:

CPAST_c15190(adc)

CSB:	CLSA_c33610(adc)

CEU:	A7L45_02865

CTAE:

BGI42_07960

CDY:	F3K33_19600

ACEL:

acsn021_01220(adc)

MHW:	ACT01_12400

PFT:

MPA:

MAO:

MAVI:

MAVU:

MAV:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MSA:	Mycsm_01688

MMI:

MMAR_4819

MMAE:

MMARE11_46490

MMM:

W7S_16890

MLI:	MULP_05051

MKN:	MKAN_10550

MYE:	AB431_17560

MXE:	MYXE_48460

MNV:	MNVI_17560

MNM:	MNVM_19640

MNE:	D174_26230

MYN:	MyAD_07535

MRH:	MycrhN_4709

MMOR:

MAIC:

MSAR:

MCHE:

MJD:	JDM601_4221

MTER:

4434518_04159(adc)

ASD:

AS9A_2277

NSL:	BOX37_13000

NAD:	NCTC11293_03327

RHA:	RHA1_ro08625

RAV:	AAT18_24735

RTM:	G4H71_04245

SMA:	SAVERM_1349(adc)

SCB:

SCAB_9691

SVL:	Strvi_5947

SCT:	SCAT_p0752(adc) SCAT_p1328(adc)

SCY:	SCATT_p03950 SCATT_p09870

SBH:	SBI_00526 SBI_08674

SHY:

SHJG_1786

SHO:	SHJGH_1551

SCI:	B446_09495

SRC:	M271_42575

SALU:

SALL:

STRE:

SLD:

STRM:

STRT:

SGS:	AVL59_35935

STSI:

A4E84_21340

SLS:	SLINC_8478

SNR:	SNOUR_31080

SPLU:

LK06_006090

SPUN:

BFF78_32205

SGV:	B1H19_11245

SALF:

SMD44_01968(adc)

SALJ:

SMD11_6826

SLX:	SLAV_28250(adc)

STRO:

STRMOE7_32465

SFK:	KY5_1742c KY5_2595c

SGE:	DWG14_01131(adc_2)

SRJ:

SRO_3431

SLK:	SLUN_08815

SDX:	C4B68_38780

SCYA:

EJ357_37715

SNQ:	CP978_02645

SKA:	CP970_33955

SVN:	CP980_25620

SALW:

CP975_07680

SHAW:

CEB94_21475

SVR:	CP971_02470

SFY:	GFH48_31020

SAQU:

EJC51_43195

SGF:	HEP81_03643

SSEO:

D0Z67_27000

SBY:	H7H31_00240

SSUB:

CP968_25430

STRI:

C7M71_000890

CUM:	NI26_09280

CUG:	C1N91_09425

ARI:	UM93_15800

RSA:	RSal33209_0180

SATK:

SA2016_2865

SRO:

Sros_7640

FRI:	FraEuI1c_1622

SEN:	SACE_5407(adc)

AMD:	AMED_6368(adc)

AMN:

RAM_32650

AMM:	AMES_6277(adc)

AMZ:	B737_6277(adc)

AOI:	AORI_2197(adc)

AJA:	AJAP_28300(adc)

AMQ:	AMETH_6177(adc)

AMYC:

CU254_20680

AMYB:

BKN51_03565

AMYY:

YIM_22705(adc)

AORI:

SD37_11975

PSEA:

WY02_01425

PSEH:

XF36_09655

SESP:

BN6_44810(adc)

KAL:

KALB_2691

KPHY:

AOZ06_28490

LED:	BBK82_28450

CAI:

Caci_2286

AEY:	CDG81_08725

CWO:

Cwoe_0117

AYM:	YM304_17700

SHI:	Shel_02690

GLP:	Glo7428_0618

CYC:	PCC7424_0744

CYJ:	Cyan7822_5322

MPRO:

BJP34_34195

CEP:	Cri9333_2345

ACY:	Anacy_5651

TOQ:	HCG51_14840

PLP:	Ple7327_1006

CPH:	Cpha266_0763

MPG:	Theba_2376

MINF:

METH:

MSUB:

METN:

AFG:	AFULGI_00012750

GAH:

MHOR:

MCJ:

MHU:

MEM:	Memar_1128

MBG:	BN140_1595

MEMA:

MMAB1_2041

MPI:

Mpet_0201

SIS:	LS215_0799

SIA:	M1425_0807

SIM:	M1627_0812

SID:

M164_0838

SIY:	YG5714_0828

SIN:	YN1551_2026

SII:

LD85_1037

SULA:

BFU36_12620

VDI:	Vdis_0265 Vdis_2137

VMO:	VMUT_0534 VMUT_1368

» show all

Reference

1 [PMID:16747621]

Authors

Davies R.

Title

Studies on the acetone-butanol fermentation: 4. Acetoacetic acid decarboxylase of Cl. acetobutylicum (BY).

Journal

Biochem J 37:230-8 (1943)
DOI:10.1042/bj0370230

Reference

2 [PMID:5911291]

Authors

Zerner B, Coutts SM, Lederer F, Waters HH, Westheimer FH.

Title

Acetoacetate decarboxylase. Preparation of the enzyme.

Journal

Biochemistry 5:813-6 (1966)
DOI:10.1021/bi00867a001

Reference

3 [PMID:19458715]

Authors

Ho MC, Menetret JF, Tsuruta H, Allen KN

Title

The origin of the electrostatic perturbation in acetoacetate decarboxylase.

Journal

Nature 459:393-7 (2009)
DOI:10.1038/nature07938

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.4

IUBMB Enzyme Nomenclature:

4.1.1.4

ExPASy - ENZYME nomenclature database:

4.1.1.4

BRENDA, the Enzyme Database:

4.1.1.4

CAS:

9025-03-0

LinkDB

DBGET integrated database retrieval system