ENZYME: 4.1.99.27
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Entry
EC 4.1.99.27 Enzyme
Name
cyclopenase;
asqI (gene name)
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
BRITE hierarchy
Sysname
(-)-cyclopenine methyl-isocyanate lyase (viridicatin-forming)
Reaction(IUBMB)
(-)-cyclopenine = viridicatin + methyl isocyanate [RN:
R13135
]
Reaction(KEGG)
R13135
Reaction
Substrate
(-)-cyclopenine [CPD:
C22623
]
Product
viridicatin [CPD:
C22644
];
methyl isocyanate [CPD:
C22645
]
Comment
This fungal enzyme catalyses a key reaction in the biosynthesis of quinolone compounds, converting the benzodiazepine structure into a quinolone structure. The enzyme is also active with (-)-4'-methoxycyclopenine.
History
EC 4.1.99.27 created 2022
Orthology
K26348
cyckopenase
Genes
ANI
:
ANIA_11201
Taxonomy
Reference
1 [PMID:
30026518
]
Authors
Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K.
Title
Enzymatic one-step ring contraction for quinolone biosynthesis.
Journal
Nat Commun 9:2826 (2018)
DOI:
10.1038/s41467-018-05221-5
Sequence
[ani:
ANIA_11201
]
Other DBs
ExplorEnz - The Enzyme Database:
4.1.99.27
IUBMB Enzyme Nomenclature:
4.1.99.27
ExPASy - ENZYME nomenclature database:
4.1.99.27
BRENDA, the Enzyme Database:
4.1.99.27
LinkDB
All DBs
DBGET
integrated database retrieval system