| Entry |
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| Name |
cyclohexa-1,5-dienecarbonyl-CoA hydratase;
cyclohexa-1,5-diene-1-carbonyl-CoA hydratase;
dienoyl-CoA hydratase;
cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect);
6-hydroxycyclohex-1-enecarbonyl-CoA hydro-lyase (cyclohexa-1,5-dienecarbonyl-CoA-forming)
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
6-hydroxycyclohex-1-ene-1-carbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming)
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| Reaction(IUBMB) |
6-hydroxycyclohex-1-ene-1-carbonyl-CoA = cyclohexa-1,5-diene-1-carbonyl-CoA + H2O [RN: R05597]
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| Reaction(KEGG) |
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| Substrate |
6-hydroxycyclohex-1-ene-1-carbonyl-CoA [CPD: C06749]
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| Product |
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD: C06322];
H2O [CPD: C00001]
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| Comment |
Forms part of the anaerobic benzoate degradation pathway, which also includes EC 1.3.8.6 [glutaryl-CoA dehydrogenase (ETF)], EC 1.3.7.8 (benzoyl-CoA reductase) and EC 4.2.1.55 (3-hydroyxbutyryl-CoA dehydratase).
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| History |
EC 4.2.1.100 created 2000, modified 2001
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K07537 | cyclohexa-1,5-dienecarbonyl-CoA hydratase |
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| Genes |
» show all
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| Reference |
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| Authors |
Laempe D, Eisenreich W, Bacher A, Fuchs G |
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| Title |
Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Harwood CS, Gibson J. |
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| Title |
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes? |
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| Journal |
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| Reference |
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| Authors |
Koch J, Eisenreich W, Bacher A, Fuchs G. |
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| Title |
Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.1.100 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 4.2.1.100 |
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| LinkDB |
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