KEGG   ENZYME: 4.2.1.155
Entry
EC 4.2.1.155                Enzyme                                 
Name
(methylthio)acryloyl-CoA hydratase;
DmdD
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-(methylsulfanyl)prop-2-enoyl-CoA hydro-lyase (acetaldehyde-forming)
Reaction(IUBMB)
3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2 (overall reaction) [RN:R10936];
(1a) 3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [RN:R10945];
(1b) 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol [RN:R10946];
(1c) 3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA [RN:R10947];
(1d) 3-oxopropanoate = acetaldehyde + CO2 [RN:R06973]
Reaction(KEGG)
R06973 R10936 R10945 R10946 R10947
Substrate
3-(methylsulfanyl)acryloyl-CoA [CPD:C20955];
H2O [CPD:C00001];
3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [CPD:C20968];
3-oxopropanoyl-CoA [CPD:C05989];
3-oxopropanoate [CPD:C00222]
Product
acetaldehyde [CPD:C00084];
methanethiol [CPD:C00409];
CoA [CPD:C00010];
CO2 [CPD:C00011];
3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [CPD:C20968];
3-oxopropanoyl-CoA [CPD:C05989];
3-oxopropanoate [CPD:C00222]
Comment
The enzyme is involved in the degradation of 3-(dimethylsulfonio)propanoate, an osmolyte produced by marine phytoplankton. Isolated from the bacterium Ruegeria pomeroyi.
History
EC 4.2.1.155 created 2015
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K20036  (methylthio)acryloyl-CoA hydratase
Genes
PFS: PFLU_2454
PTV: AA957_02575
PAZO: AYR47_18985
PMAB: U0037_12285
PFW: PF1751_v1c21520
PFF: PFLUOLIPICF725950
PFX: A7318_10225
PPEG: KUA23_11310
PCAA: V6L78_22080
APRS: BI364_09690
HEL: HELO_3943
HAK: KO116_00192
HHH: CLM76_03085
HSV: HNO53_19245
HASO: B2G49_18265
HCAM: I4484_18915
HAMC: HNO52_18825
HSX: HNO51_18970
HTX: EKK97_21245
MMW: Mmwyl1_3020
MME: Marme_2603
MPC: Mar181_1042
MPRI: MP3633_1206
MARD: IBG28_06875
MFOI: JSY38_15840
MPRF: J8N69_12515
MRHI: KDW99_13955
MPON: MACH16_21730(fad)
MATH: THO17_12260
MARL: HH196_06500
VFF: VITFI_CDS3132
REU: Reut_B4798 Reut_B5283
RME: Rmet_2366
CBW: RR42_s1574
CCUP: BKK81_29835
CUP: BKK80_26520
CUU: BKK79_32405
COX: E0W60_20475
BGF: BC1003_5123
BGD: bgla_2g28180
BXE: Bxe_C0923
BXB: DR64_7526
PCAF: DSC91_002454
PACS: FAZ98_16225
PPK: U875_11015
PPNO: DA70_03425
PPNM: LV28_02900
PRB: X636_23685
PPUL: RO07_21765
PSPU: NA29_15325
PAPI: SG18_20730
PVE: UC34_13105
POX: MB84_17630
PFG: AB870_00175
PNR: AT302_19050
PFIB: PI93_014860
PCOM: NTU39_14705
PANN: PanNE5_35710(fad)
PANX: OYT13_12485
TVL: FAZ95_34500
BOJ: CBF45_03330 CBF45_06585
PUT: PT7_0125
AFA: UZ73_01330 UZ73_07535
AFQ: AFA_11055
AAQU: D3M96_11865
AAMM: FE795_10295
ALCN: MID00_16110
PIG: EGT29_13920
KGY: EHF36_03780 EHF36_07020
PUD: G9Q38_03570 G9Q38_10260
RFR: Rfer_0274
RSB: RS694_00925
RHY: RD110_11725
RHF: EUB48_13060
RHOA: HZ993_17690
RHOB: HTY51_10060
RMK: RAN89_01095
RLH: MIZ03_2355
RHOF: AB3G31_05730
POL: Bpro_3111
PNA: Pnap_0605
ACK: C380_01285
ACRA: BSY15_1662
ACIO: EAG14_20805
ARAD: KI609_01255
ACIQ: ACDW_03000
ACIV: EXV95_17810
VAP: Vapar_4402
VPE: Varpa_5065
VPD: VAPA_1c45750
VAA: AX767_13925
VBO: CKY39_14475 CKY39_27680
VAM: C4F17_23700
VAZ: H7F35_06625 H7F35_34340
VAV: IG196_11925 IG196_25735
VAE: RZE79_12510 RZE79_25630 RZE79_31985
VAX: H7F36_01485
CTT: CtCNB1_2298 CtCNB1_4139
CTES: O987_24730
CAQT: KAQ61_13310
AANT: HUK68_18610
CRJ: QMY55_20410
RTA: Rta_25000
OTK: C6570_11155
LIM: L103DPR2_01477(paaF_3)
LIH: L63ED372_00989(paaF_3)
HYR: BSY239_2238
HYB: Q5W_08965
HYL: LPB072_16170
HYC: E5678_08855
HPSE: HPF_07975(paaF3)
HYN: F9K07_12120
HTN: KI616_18245
HCZ: G9Q37_03380
HYY: JNX00_10535
HYDR: SOM08_10880
HYDA: ABSY19_24510
CBAA: SRAA_0578
CBAB: SMCB_0808
HGR: DW355_09600
STHM: IS481_04375 IS481_07635
PBH: AAW51_0441
SNN: EWH46_03165
SMIO: CATMQ487_34530(fad_1) CATMQ487_47190(fad_2)
ATER: MW290_20370
LCH: Lcho_0994
HSE: Hsero_4006
HSZ: ACP92_20000
HRB: Hrubri_3960
HEE: hmeg3_01130
HHF: E2K99_20860
HFR: G5S34_21750
HEW: HBDW_40960
SHD: SUTH_01232
DOE: DENOEST_0611(dmdD)
DENI: B9N43_09935
EBA: ebA5318 ebA5619
ABRE: pbN1_04090
APET: ToN1_09320
AZO: azo2498(paaG3)
AOA: dqs_2651
AZA: AZKH_2163
AZI: AzCIB_2731
AZD: CDA09_14720
TMZ: Tmz1t_2492
TCL: Tchl_1082
THK: CCZ27_15680 CCZ27_17835
TAK: Tharo_1120
DDZ: DSYM_02080
BEBA: BWI17_21020
MLO: mlr6976
MEAA: ACG873_07965
NIY: FQ775_21445
NTU: NTH_01134(dmdD)
MESO: BSQ44_21420
CHEA: PVE73_06185
AMIS: Amn_19980
ORM: HTY61_05125
ESJ: SJ05684_b59780
EAK: EKH55_4145
ATU: Atu1417(fad)
ALF: CFBP5473_16040
AVQ: HRR99_21620
ASAL: CFBP5507_05425
ALEG: CFBP4996_22065
AGRC: GSF67_05775
NGL: RG1141_CH41200
NGG: RG540_CH41720
NEO: CYG48_15380
NPM: QEO92_25050
RHT: NT26_3192(fad)
RFV: RFYW14_03205
PDES: FE840_020140
HOE: IMCC20628_02027
BJA: blr7844(fad)
BJU: BJ6T_84670
BJP: RN69_40915
BRA: BRADO0962
BBT: BBta_5093 BBta_7093
BRS: S23_09440(fad)
AOL: S58_66670
BRC: BCCGELA001_33005
BRAD: BF49_4145
BIC: LMTR13_35510
BRO: BRAD285_0457
BRK: CWS35_02980
BOT: CIT37_06570
BRQ: CIT40_28175
BGQ: X265_33275
BGZ: XH91_31675
BSYM: CIT39_27190
BBET: F8237_19635
BARH: WN72_05965
BVZ: BRAD3257_8266(fad)
BEL: BE61_14310(fad)
BDG: LPJ38_00680
BSEP: HAP48_0019025
BQB: J4P68_0022520
BSEI: KMZ68_23760
BBAN: J4G43_047470
BCAN: BcanWSM471_05700
BAUT: QA635_39400
BBRA: QA636_40455
BGK: IC762_33975
BCOU: IC761_33305
BPAH: QA639_39410
BXN: I3J27_36065
BROS: QUH67_04225
BRAZ: LRP30_39450
BOY: LQG66_19995
BRAY: ML401_30650
BRAI: FJV43_12740
BRAA: NL528_41125
BLUP: AB3L03_14130
RPA: TX73_009185
RPB: RPB_3578
RPD: RPD_1886
RPE: RPE_3803
RPT: Rpal_1988
RPX: Rpdx1_3746
RBK: E0H22_20670
RHOR: ONR75_28360
RHOL: RBJ75_11360
TRB: HB776_16035
TALZ: RPMA_23635
TARD: RSO67_09770 RSO67_11550
TARV: FIU28_22110
BVES: QO058_30965
PTAW: DW352_17125
MNO: Mnod_6456
MAQU: Maq22A_c00770(caiD)
MEE: DA075_12475
MTEA: DK419_20350
MIND: mvi_14950(paaG)
RHZ: RHPLAN_62540 RHPLAN_69940
PHL: KKY_2321
PEM: OF122_05250
PNF: V6617_05210
DEQ: XM25_21120
DEI: C4375_05470
DEA: FPZ08_20665
DSAL: K1X15_01035
DEVO: H4N61_07420
DOY: JI749_05660
DEVD: GHV40_10240
DRI: QOV41_19015
YTI: FNA67_02440
MHAR: L1P08_13135
BVR: BVIR_1682
BLAG: BLTE_16420(fad)
MAAD: AZF01_17850 AZF01_20095
MLUT: JET14_00305 JET14_17550
PSIN: CAK95_06170 CAK95_14960
BRN: D1F64_22285
PPHR: APZ00_03860 APZ00_05265
LAP: ACP90_06325
LABR: CHH27_14215
LABT: FIU93_11965(paaF2)
LAGG: B0E33_17875
RPOP: K1718_06715
PHR: C6569_04915
PSTG: E8M01_13635
PAQT: E8L99_07120
ACUT: MRB58_01555 MRB58_08790(dmdD)
SIL: SPO3805(dmdD)
JAN: Jann_0665
PGA: PGA1_262p01540 PGA1_262p01850
PGL: PGA2_239p1720
PGD: Gal_03918
PHP: PhaeoP97_03685
PPIC: PhaeoP14_03588
PHQ: D1820_17695
PHAE: N1037_19035 N1037_21930
LMD: METH_04510
LEJ: ETW24_05600
LEV: ETW23_14095
LEIM: K3557_03655(dmdD)
CID: P73_1463
CEH: CEW89_18655
CBAK: DA792_03695
YPAC: CEW88_03015
YAN: AYJ57_10060
SUAM: BOO69_11775
SULZ: C1J03_19935
SPOT: G6548_08570
SMED: JNX03_19590(dmdD)
SUAL: KDD17_12510
SULB: IV89_002035
SULY: ABM428_08230
SULP: AADW22_08255
SPSE: SULPSESMR1_00293(dmdD) SULPSESMR1_03318(dmdD)
AHT: ANTHELSMS3_04102(dmdD)
SAGU: CDO87_15325
SSTL: ABFK29_18360
OCD: FHY55_02030
MALU: KU6B_17010(fad)
TGL: HFZ77_03705 HFZ77_13875
PALX: GQA70_14310
LALG: LentiSH36_00182
TRY: QF118_09170
PLCG: RVY76_09350
MARU: FIU81_05950(echA1)
ASCA: QEZ52_06575(dmdD)
PDE: Pden_2560
PCON: B0A89_04960
PZH: CX676_15280
PARO: CUV01_03995 CUV01_04030 CUV01_08275
PARU: CYR75_11380
PARS: DRW48_04255
PARR: EOJ32_01265
PKD: F8A10_09685
PPAN: ESD82_11390
PSAN: HGN31_07185
PMAU: CP157_00210(dmdD)
PMEH: JWJ88_01160
PSEW: JHW44_00370
PSAP: JHX88_11465
PFIS: JHX87_11675
PAEX: JHW48_01000 JHW48_17445
PSTL: JHW45_02485
PVER: E3U25_21305
PALS: PAF20_15865
PDIM: PAF18_14755
PFEO: E3U26_09575
PTP: RCA23_c26210(crt)
DON: BSK21_06015
MALC: QQG91_01990 QQG91_14785(dmdD)
RBZ: B9057_07500
SALO: EF888_01205 EF888_16370
SEDI: EBB79_18915
PPSO: QPJ95_17065
PPRU: FDP22_13980
PALW: PSAL_022640(dmdD)
PSHQ: F3W81_00380 F3W81_12695
PGV: SL003B_2869(fad)
GCE: KYE46_16960
GYJ: AADW23_06125
NSM: JO391_18160
AMYL: QBD29_08785
AMAQ: GO499_03935
PBAE: P8S53_04770
RBG: BG454_07465
SINR: O5O51_14205(dmdD)
SSY: SLG_07670 SLG_35020
ERY: CP97_08825
RAP: RHOA_5185(dmdD)
FER: FNB15_11965
TII: DY252_19175
THAI: IT893_02215
TTB: MACH01_04440(fad)
NACI: NUH88_16325
TMO: TMO_c0641
PAUU: E8A73_040205
HHY: Halhy_0462
SLI: Slin_1561
SPIR: CWM47_14210
SPIK: EXU85_00745
SRHO: HH216_17380
SENF: GJR95_37955
RHOZ: GXP67_01720
EOL: Emtol_1593
RSI: Runsl_0511
RUP: DTQ70_10440
MARB: CJ263_16340
MLIO: NYZ99_12385
SGRF: SGFS_022310
SLAU: SLA_7088
SPHV: F9278_04880
SGX: H4W23_04770
KIT: CFP65_0448
ALX: LVQ62_14330
ARS: ADJ73_05985
BLIN: BLSMQ_1405
BCAU: I6G59_01295
BREB: PGC08_07225
NOCQ: QI633_24580
AGRA: AGRA3207_007192
FRI: FraEuI1c_2567
AMD: AMED_3269(paaG)
AMN: RAM_16630
AMM: AMES_3233(paaG)
AMZ: B737_3233(paaG)
APRT: MUY14_19030
AMOG: QRX60_32475
ANW: QP939_44825
PSEH: XF36_04825
PAUT: Pdca_17660(paaG_4)
PBRO: HOP40_01125
PPEL: H6H00_01695
PSDS: K1T35_21665
ACTY: OG774_06220
DVC: Dvina_24630
DAUR: Daura_31230
DMAT: Dmats_20240
JTL: M6D93_11190
 » show all
Reference
1  [PMID:23704947]
  Authors
Tan D, Crabb WM, Whitman WB, Tong L
  Title
Crystal structure of DmdD, a crotonase superfamily enzyme that catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA.
  Journal
PLoS One 8:e63870 (2013)
DOI:10.1371/journal.pone.0063870
  Sequence
[sil:SPO3805]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.155
IUBMB Enzyme Nomenclature: 4.2.1.155
ExPASy - ENZYME nomenclature database: 4.2.1.155
BRENDA, the Enzyme Database: 4.2.1.155
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