KEGG   ENZYME: 4.2.2.8
Entry
EC 4.2.2.8                  Enzyme                                 

Name
heparin-sulfate lyase;
heparin-sulfate eliminase;
heparitin-sulfate lyase;
heparitinase I;
heparitinase II
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
Sysname
heparin-sulfate lyase
Reaction(IUBMB)
Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
Comment
Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
History
EC 4.2.2.8 created 1972
Orthology
K19051  heparin/heparan-sulfate lyase
K19052  heparan-sulfate lyase
Genes
BTH: BT_4657 BT_4662
BTHO: Btheta7330_03330(hepC_1) Btheta7330_03335(hepC_2)
BHL: Bache_1616
BXY: BXY_37640 BXY_37690
BOA: Bovatus_04863(hepC_2) Bovatus_04868(hepC_3)
BCEL: BcellWH2_01704(hepC)
BCAE: A4V03_04720
BHF: C3V43_00350
BIS: DXK01_000620
ASH: AL1_01210 AL1_01260
COC: Coch_0606
 » show all
Reference
1  [PMID:5484472]
  Authors
Hovingh P, Linker A.
  Title
The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria.
  Journal
J Biol Chem 245:6170-5 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.8
IUBMB Enzyme Nomenclature: 4.2.2.8
ExPASy - ENZYME nomenclature database: 4.2.2.8
BRENDA, the Enzyme Database: 4.2.2.8
CAS: 37290-86-1
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