KEGG   ENZYME: 4.4.1.33Help
Entry
EC 4.4.1.33                 Enzyme                                 

Name
R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase;
rpcG (gene name)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
[R-phycocyanin alpha-subunit]-Cys84-phycourobilin:(2R,3E)-phycoerythrobilin lyase/isomerase
Reaction(IUBMB)
[R-phycocyanin alpha-subunit]-Cys84-phycourobilin = apo-[R-phycocyanin alpha-subunit] + (2R,3E)-phycoerythrobilin
Substrate
[R-phycocyanin alpha-subunit]-Cys84-phycourobilin
Product
apo-[R-phycocyanin alpha-subunit];
(2R,3E)-phycoerythrobilin
Comment
The enzyme, characterized from the cyanobacterium Synechococcus sp. WH8102, catalyses the covalent attachment of the phycobilin chromophore phycoerythrobilin to cysteine 84 of the alpha subunit of the phycobiliprotein R-phycocyanin and its isomerization to phycourobilin.
History
EC 4.4.1.33 created 2015
Orthology
K20713  R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase
Genes
SYW: SYNW2025
SYD: Syncc9605_0418
SYNK: KR100_03605
Taxonomy
Reference
1  [PMID:19182270]
  Authors
Blot N, Wu XJ, Thomas JC, Zhang J, Garczarek L, Bohm S, Tu JM, Zhou M, Ploscher M, Eichacker L, Partensky F, Scheer H, Zhao KH
  Title
Phycourobilin in trichromatic phycocyanin from oceanic cyanobacteria is formed post-translationally by a phycoerythrobilin lyase-isomerase.
  Journal
J Biol Chem 284:9290-8 (2009)
DOI:10.1074/jbc.M809784200
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.33
IUBMB Enzyme Nomenclature: 4.4.1.33
ExPASy - ENZYME nomenclature database: 4.4.1.33
BRENDA, the Enzyme Database: 4.4.1.33
LinkDB All DBs

DBGET integrated database retrieval system