Entry |
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Name |
L-dopachrome isomerase;
dopachrome tautomerase;
tyrosinase-related protein 2;
TRP-1;
TRP2;
TRP-2;
tyrosinase-related protein-2;
dopachrome Delta7,Delta2-isomerase;
dopachrome Delta-isomerase;
dopachrome conversion factor;
dopachrome isomerase;
dopachrome oxidoreductase;
dopachrome-rearranging enzyme;
DCF;
DCT;
dopachrome keto-enol isomerase;
L-dopachrome-methyl ester tautomerase
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Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
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Sysname |
L-dopachrome keto-enol isomerase
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Reaction(IUBMB) |
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate [RN: R03673]
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Reaction(KEGG) |
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Substrate |
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Product |
5,6-dihydroxyindole-2-carboxylate [CPD: C04185]
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Comment |
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).
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History |
EC 5.3.3.12 created 1992, modified 1999, modified 2005
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Pathway |
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Solano F, Jimenez-Cervantes C, Martinez-Liarte JH, Garcia-Borron JC, Jara JR, Lozano JA. |
Title |
Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase. |
Journal |
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Sequence |
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Reference |
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Authors |
Pawelek JM. |
Title |
Dopachrome conversion factor functions as an isomerase. |
Journal |
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Reference |
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Authors |
Pennock JL, Behnke JM, Bickle QD, Devaney E, Grencis RK, Isaac RE, Joshua GW, Selkirk ME, Zhang Y, Meyer DJ |
Title |
Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 5.3.3.12 |
ExPASy - ENZYME nomenclature database: | 5.3.3.12 |
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LinkDB |
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