KEGG ENZYME: 5.3.3.12

ENZYME: 5.3.3.12

Entry

EC 5.3.3.12 Enzyme

Name

L-dopachrome isomerase;
dopachrome tautomerase;
tyrosinase-related protein 2;
TRP-1;
TRP2;
TRP-2;
tyrosinase-related protein-2;
dopachrome Delta7,Delta2-isomerase;
dopachrome Delta-isomerase;
dopachrome conversion factor;
dopachrome isomerase;
dopachrome oxidoreductase;
dopachrome-rearranging enzyme;
DCF;
DCT;
dopachrome keto-enol isomerase;
L-dopachrome-methyl ester tautomerase

Class

Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds

Sysname

L-dopachrome keto-enol isomerase

Reaction(IUBMB)

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate [RN:R03673]

Reaction(KEGG)

R03673

Substrate

L-dopachrome [CPD:C01693]

Product

5,6-dihydroxyindole-2-carboxylate [CPD:C04185]

Comment

A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).

History

EC 5.3.3.12 created 1992, modified 1999, modified 2005

Pathway

ec00350

Tyrosine metabolism

ec01100

Metabolic pathways

Orthology

K01827

dopachrome tautomerase

K22203

dopachrome tautomerase

Genes

HSA:

1638(DCT)

PTR:	452622(DCT)

PPS:	100975768(DCT)

GGO:	101133130(DCT)

PON:	100438537(DCT)

NLE:	100595345(DCT)

MCC:	694577(DCT)

MCF:	102127456(DCT)

CSAB:

103214664(DCT)

RRO:	104658800(DCT)

RBB:	108519938(DCT)

CJC:	100389709(DCT)

MMU:	13190(Dct)

MCAL:

110308926(Dct)

MPAH:

110325053(Dct)

RNO:	290484(Dct)

MUN:	110565610 110565611

CGE:	100764118(Dct)

NGI:	103729035(Dct)

HGL:	101716269(Dct)

CCAN:

109702871(Dct)

OCU:	100353923(DCT)

TUP:	102484655(DCT)

CFA:	485520(DCT)

VVP:	112923776(DCT)

AML:	100467156(DCT)

UMR:	103657595(DCT)

UAH:	113251084(DCT)

ORO:	101381485(DCT)

ELK:

111147121

FCA:	101094977(DCT)

PTG:	102953286(DCT)

PPAD:

109264168(DCT)

AJU:	106984228(DCT)

BTA:	280761(DCT)

BOM:	102285590(DCT)

BIU:	109566904(DCT)

BBUB:

102401407(DCT)

CHX:	102169882(DCT)

OAS:	100170232(DCT)

SSC:	574066(DCT)

CFR:

102519441

BACU:

103009988(DCT)

LVE:	103070463(DCT)

OOR:	101273282(DCT)

DLE:	111176330(DCT)

PCAD:

102981621(DCT)

ECB:	100058776(DCT)

EPZ:	103559368(DCT)

EAI:	106846221(DCT)

MYB:	102258295(DCT)

MYD:	102754085(DCT)

MNA:	107545906(DCT)

HAI:	109395407(DCT)

DRO:	112310734(DCT)

PALE:

102883222(DCT)

RAY:	107513731(DCT)

MJV:	108405185(DCT)

LAV:	100656003(DCT)

TMU:

101340616

MDO:	100027305(DCT)

SHR:	100920202(DCT)

PCW:	110193809(DCT)

OAA:	100081295(DCT)

GGA:	395775(DCT)

MGP:	100543862(DCT)

CJO:	107308023(DCT)

NMEL:

110392912(DCT)

APLA:

101792699(DCT)

ACYG:

106045352(DCT)

TGU:	100230498(DCT)

LSR:	110470581(DCT)

SCAN:

103812281(DCT)

GFR:	102032174(DCT)

FAB:	101812075(DCT)

PHI:	102103043(DCT)

PMAJ:

107199948(DCT)

CCAE:

111944860(DCT)

CCW:	104685963(DCT)

ETL:	114057672(DCT)

FPG:	101918681(DCT)

FCH:	102059594(DCT)

CLV:	102092544(DCT)

EGZ:	104122461(DCT)

NNI:	104014398(DCT)

ACUN:

113484458(DCT)

PADL:

103918279(DCT)

AAM:	106491647(DCT)

ASN:	102378044(DCT)

AMJ:	102571729(DCT)

PSS:	102443459(DCT)

CMY:	102934273(DCT)

CPIC:

101935852(DCT)

ACS:	100557746(dct)

PVT:	110073874(DCT)

PBI:	103062097(DCT)

PMUR:

107293449(DCT)

TSR:	106540695(DCT)

PMUA:

114596563(DCT)

GJA:	107116639(DCT)

XLA:	100381161(dct.L)

XTR:	549915(dct)

NPR:	108786125(DCT)

DRE:	58074(dct)

SRX:	107722116(dct)

SANH:

107662564 107666652

SGH:	107558385(dct) 107567421

CCAR:

109052004 109082707

IPU:	108266888(dct)

PHYP:

113524332(dct)

AMEX:

103044028(dct)

EEE:	113590857(dct)

TRU:	101077388(dct)

TNG:	GSTEN00026098G001

LCO:	104922692(dct)

NCC:	104947502(dct)

MZE:	101480314(dct)

ONL:	100693792(dct)

OLA:	101166914(dct)

XMA:	102224148(dct)

XCO:	114148268(dct)

PRET:

103459953(dct)

CVG:	107092114(dct)

NFU:	107389964(dct)

KMR:	108239787(dct)

ALIM:

106528179(dct)

AOCE:

111569955(dct)

CSEM:

103392019(dct)

POV:	109631435(dct)

LCF:	108901600(dct)

SDU:	111218368(dct)

SLAL:

111662191(dct)

HCQ:	109523392(dct)

BPEC:

110173138(dct)

MALB:

109958128(dct)

SASA:

100136917(dct) 100137092 106582441 106586271

OTW:	112224185 112234462 112237246

SALP:

111975947

ELS:	105024741 105024769

SFM:	108942570(dct)

PKI:	111834142(dct)

LCM:	102360769(DCT)

CMK:	103176933(dct)

RTP:	109915622(dct)

BFO:	118407975 118431962 118431963

CIN:

100187516

DME:	Dmel_CG18550(yellow-f) Dmel_CG8063

DER:	6552582 6553564

DSI:	Dsimw501_GD20528(Dsim_GD20528) Dsimw501_GD20529(Dsim_GD20529)

DYA:	Dyak_GE24474 Dyak_GE24475

DSR:

110187658

DPO:	Dpse_GA27163

DPE:

6587497

DMN:

108154170

DWI:	6647655 6647725

DGR:	Dgri_GH19199

DMO:	Dmoj_GI24232

DAZ:

DNV:

DHE:

MDE:

LCQ:

AGA:	AgaP_AGAP003095 AgaP_AGAP003096 AgaP_AGAP003097 AgaP_AGAP004324

AAG:	5563570 5563593 5563621

AALB:

109412583 109412586 109412587 109433602 109433623 115259651

CQU:	CpipJ_CPIJ002393 CpipJ_CPIJ002394 CpipJ_CPIJ002395

TCA:	657666(Y-f)

DPA:

109544651

ATD:

109609256

NVL:

108566790

BMOR:

101737203(yellow-11) 101737351 101737492 101738044 101738170 101738305 101738837 101740731 101741665 101741808 101741957 693000(Y-fa) 693002(Y-fb) 693004(Y-f2) 693006

BMAN:

114240104 114240105 114240199 114240221 114240222 114243745 114243750 114245737 114245738 114245740 114245769 114245811 114245812 114245834 114251500 114251509 114252251 114252906

DPL:	KGM_215143A KGM_215143B

PMAC:

106713422 106713423

PRAP:

110997292 110997307

HAW:	110383034 110383035 110383392

TNL:

113509028

PXY:	105380741 105382882

TSP:	Tsp_01297 Tsp_13809

» show all

Reference

1 [PMID:8573077]

Authors

Solano F, Jimenez-Cervantes C, Martinez-Liarte JH, Garcia-Borron JC, Jara JR, Lozano JA.

Title

Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase.

Journal

Biochem J 313 ( Pt 2):447-53 (1996)
DOI:10.1042/bj3130447

Sequence

[mmu:13190]

Reference

2 [PMID:2106316]

Authors

Pawelek JM.

Title

Dopachrome conversion factor functions as an isomerase.

Journal

Biochem Biophys Res Commun 166:1328-33 (1990)
DOI:10.1016/0006-291X(90)91011-G

Reference

3 [PMID:9794786]

Authors

Pennock JL, Behnke JM, Bickle QD, Devaney E, Grencis RK, Isaac RE, Joshua GW, Selkirk ME, Zhang Y, Meyer DJ

Title

Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.

Journal

Biochem J 335 ( Pt 3):495-8 (1998)
DOI:10.1042/bj3350495

Other DBs

ExplorEnz - The Enzyme Database:

5.3.3.12

IUBMB Enzyme Nomenclature:

5.3.3.12

ExPASy - ENZYME nomenclature database:

5.3.3.12

BRENDA, the Enzyme Database:

5.3.3.12

CAS:	130122-81-5

LinkDB

DBGET integrated database retrieval system