Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)

L-glutamate:ammonia ligase (ADP-forming)

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine [RN:R00253]

R00253

ATP [CPD:C00002];
L-glutamate [CPD:C00025];
NH3 [CPD:C00014]

Glutamine synthetase, which catalyses the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. Several types have been described, differing in their oligomeric structures and cofactor requirements.

EC 6.3.1.2 created 1961, modified 2016