Entry
Name
P-type Mn2+ transporter;
Mn(II)-translocating P-type ATPase;
Mn2+-exporting ATPase;
P1B-type ATPase (ambiguous);
ctpC (gene name)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (P-type, Mn2+-exporting)
Reaction(IUBMB)
ATP + H2O + Mn2+[side 1] = ADP + phosphate + Mn2+[side 2]
Substrate
Product
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, detected in mycobacteria, is a high affinity slow turnover ATPase exporting Mn2+.
History
EC 7.2.2.22 created 2021
Orthology
K12950 manganese-transporting P-type ATPase C
Genes
MRM : A7982_04415 A7982_04417
CACE : CACET_c29480(ctpC) CACET_c29510
DRU : Desru_0231 Desru_0880 Desru_1040
GFE : Gferi_11795 Gferi_18770
PHX : KGNDJEFE_02142(ctpC)
STED : SPTER_38010(ctpC_1) SPTER_43450(ctpC_2)
MID : MIP_04141 MIP_06163 MIP_06567
MYO : OEM_27760 OEM_32830 OEM_41190
MCHI : AN480_13080 AN480_17385 AN480_21490
MMI : MMAR_1271(ctpC) MMAR_2147
MMAE : MMARE11_12370(ctpC)
MMM : W7S_14190 W7S_20435 W7S_21845
MXE : MYXE_22660(ctpC_1) MYXE_37180(ctpC_2)
MBAI : MB901379_01162(ctpV_1)
MHEK : JMUB5695_03663(ctpC_2)
MKY : IWGMT90018_13100(ctpC_1) IWGMT90018_25560(ctpC_2) IWGMT90018_46350(ctpC_3)
MAUU : NCTC10437_05089(ctpC)
MSAL : DSM43276_02937(ctpV)
MTER : 4434518_03007(ctpC)
MVM : MJO54_04605(ctpC) MJO54_17105(ctpC)
TPUL : TPB0596_30020(ctpC)
PAUT : Pdca_30780 Pdca_69050(ctpC)
FPOL : ERS445057_01001(copA_2)
» show all
Taxonomy
Reference
Authors
Padilla-Benavides T, Long JE, Raimunda D, Sassetti CM, Arguello JM
Title
A novel P(1B)-type Mn2+-transporting ATPase is required for secreted protein metallation in mycobacteria.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.22
ExPASy - ENZYME nomenclature database: 7.2.2.22
LinkDB
All DBs