EC                 Enzyme                                 

protein-glutamine gamma-glutamyltransferase;
Factor XIIIa;
fibrin stabilizing factor;
glutaminylpeptide gamma-glutamyltransferase;
polyamine transglutaminase;
tissue transglutaminase;
R-glutaminyl-peptide:amine gamma-glutamyl transferase
BRITE hierarchy
protein-glutamine:amine gamma-glutamyltransferase
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 [RN:R03983]
protein glutamine [CPD:C02583];
alkylamine [CPD:C01664]
protein N5-alkylglutamine [CPD:C03636];
NH3 [CPD:C00014]
Requires Ca2+. The gamma-carboxamide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N6-(5-glutamyl)-lysine crosslinks. Formed by proteolytic cleavage from plasma Factor XIII
EC created 1978, modified 1981, modified 1983
K00686  protein-glutamine gamma-glutamyltransferase
K03917  coagulation factor XIII A1 polypeptide
K05619  transglutaminase 1
K05620  transglutaminase 3
K05621  transglutaminase 4
K05622  transglutaminase 5
K05623  transglutaminase 7
K05624  transglutaminase 6
K05625  transglutaminase 2
K22452  protein-glutamine gamma-glutamyltransferase
HSA: 116179(TGM7) 2162(F13A1) 343641(TGM6) 7047(TGM4) 7051(TGM1) 7052(TGM2) 7053(TGM3) 9333(TGM5)
PTR: 452814(TGM1) 453375(TGM5) 458043(TGM3) 458044(TGM6) 460311(TGM4) 462413(F13A1) 467667(TGM7) 469937(TGM2)
PPS: 100977152(TGM7) 100977828(TGM5) 100978535(TGM1) 100980699(TGM4) 100982798(F13A1) 100994168(TGM3) 100994169(TGM2) 100995088(TGM6)
GGO: 101124803(TGM1) 101138298(TGM4) 101143373(TGM6) 101144333(F13A1) 101149000(TGM5) 101149948(TGM7) 101154327(TGM2) 109025182(TGM3)
PON: 100189556(TGM4) 100440931(F13A1) 100441290(TGM2) 100453552(TGM6) 100454156(TGM3) 100457869(TGM1) 100459707(TGM5) 100460447(TGM7)
NLE: 100581513(F13A1) 100584804(TGM1) 100589876(TGM6) 100592355(TGM3) 100602130(TGM4) 100604663(TGM5) 100605556(TGM7) 100606817(TGM2)
MCC: 100430348(TGM6) 706777(TGM2) 711264(F13A1) 712605(TGM5) 712676(TGM7) 714883(TGM4) 715854(TGM1) 716498(TGM3)
MCF: 102118894(TGM1) 102122746(TGM2) 102124679(TGM4) 102126128(F13A1) 102129616(TGM5) 102130654(TGM7) 102134146(TGM6) 102141556(TGM3)
CSAB: 103215687(TGM3) 103220889(TGM6) 103222237(F13A1) 103227506(TGM4) 103228722(TGM1) 103245746(TGM5) 103246097(TGM7) 103246306(TGM2)
RRO: 104655820(TGM2) 104662683(TGM1) 104668593(F13A1) 104670984(TGM4) 104674632(TGM6) 104674634(TGM3) 104678482(TGM5) 104678483(TGM7)
RBB: 108518211(TGM7) 108519166(TGM5) 108519823(TGM2) 108529980(TGM3) 108529982(TGM6) 108532307(TGM4) 108537036(F13A1) 108540940(TGM1)
CJC: 100390001(TGM2) 100390536(TGM7) 100401849(F13A1) 100402216(TGM3) 100402574(TGM6) 100406524(TGM4) 100410848(TGM1) 100415505(TGM5)
SBQ: 101028218(TGM2) 101029891(TGM5) 101043441(TGM7) 101046928(F13A1) 101047215(TGM1) 101047452(TGM4) 101048601(TGM3) 101048923(TGM6) 101053414
MMU: 21816(Tgm1) 21817(Tgm2) 21818(Tgm3) 241636(Tgm6) 331046(Tgm4) 640543(Tgm7) 74145(F13a1) 74176(Tgm5)
RNO: 102552199(Tgm7) 296152(Tgm6) 366189(Tgm3) 56083(Tgm2) 60327(F13a1) 60335(Tgm1) 64679(Tgm4) 691932(Tgm7l1)
CGE: 100751827(Tgm6) 100752403(Tgm3) 100756034(Tgm7) 100756318(Tgm5) 100757784(Tgm1) 100759289(Tgm2) 100761709(F13a1) 100762929(Tgm4)
NGI: 103725088(Tgm7) 103726570(Tgm5) 103728480(Tgm2) 103732915(F13a1) 103739419(Tgm1) 103747165(Tgm4) 103751142(Tgm3) 103751150(Tgm6)
HGL: 101699097(Tgm2) 101715346(F13a1) 101716908(Tgm7) 101720615(Tgm5) 101721908(Tgm3) 101722232(Tgm4) 101722267(Tgm6) 101723323(Tgm1)
CCAN: 109682286(Tgm5) 109682288(Tgm7) 109685845(Tgm1) 109686490(Tgm4) 109692091(Tgm2) 109692901(Tgm3) 109692905(Tgm6) 109700024(F13a1)
TUP: 102484022(TGM6) 102491834(TGM3) 102496909(TGM2) 102497321(F13A1) 102501064(TGM1) 102502596(TGM7) 102503026(TGM5)
CFA: 403630(TGM1) 477180(TGM3) 478711(F13A1) 485807(TGM6) 485867(TGM2) 487522(TGM5) 487523(TGM7)
AML: 100468726(TGM7) 100468973(EPB42) 100471855(TGM6) 100472103(TGM3) 100473377(TGM1) 100477542(TGM2) 100479900(F13A1) 105238755(TGM5)
UMR: 103664944(F13A1) 103669768(TGM2) 103673406(TGM5) 103673528(TGM7) 103674507(TGM3) 103674509(TGM6) 103679327(TGM1)
ORO: 101369632(F13A1) 101371443(TGM2) 101376048(TGM1) 101376904(TGM3) 101377195(TGM6) 101381779(TGM7) 101382071(TGM5)
FCA: 101080534(F13A1) 101080542(TGM7) 101080797(TGM5) 101082066(TGM1) 101083506(TGM6) 101083762(TGM3) 101098215(TGM2)
PTG: 102954308(F13A1) 102963634(TGM1) 102965789(TGM7) 102967219(TGM5) 102972509(TGM3) 102972783(TGM6) 102972819(TGM2)
AJU: 106968495(TGM5) 106968557(TGM7) 106974485(TGM2) 106984886(F13A1) 106985990(TGM3) 106986038 106986039(TGM6) 106987870(TGM1)
BTA: 281528(TGM2) 407997(TGM1) 505080(TGM3) 514767(TGM5) 536356(TGM6) 538521(TGM7) 617881(F13A1)
BOM: 102268247(TGM3) 102268807(TGM6) 102278981(TGM5) 102279262(TGM7) 102282269(TGM2) 102282528(F13A1) 102287783(TGM1)
BIU: 109564768(TGM1) 109567220(TGM3) 109567436(TGM2) 109567644(TGM6) 109575225(TGM7) 109575778(TGM5) 109577234(F13A1)
PHD: 102325869(TGM3) 102332777(TGM5) 102333383(TGM7) 102336314(TGM2) 102337526(F13A1) 102339860(TGM1) 102341793(TGM6)
CHX: 102169238(F13A1) 102177982(TGM1) 102179888(TGM5) 102180159(TGM7) 102185477(TGM2) 102187690(TGM6) 102188149(TGM3)
OAS: 101105177(TGM3) 101106629(TGM7) 101108612(F13A1) 101109916(TGM5) 101114043(TGM6) 101114274(TGM1) 101123140(TGM2)
SSC: 100152931(TGM7) 100153042(TGM3) 100153504(F13A1) 100154530(TGM2) 100156489(TGM1) 100158178(TGM5) 106506638(TGM6)
CFR: 102506156(TGM3) 102512777(TGM6) 102521823(TGM2) 102522024(TGM5) 102522457(TGM7) 102522644(F13A1) 102522761(TGM1)
CDK: 105085004(TGM2) 105096047(TGM3) 105096062(TGM6) 105099774(F13A1) 105101729(TGM7) 105101755(TGM5) 105102427(TGM1)
BACU: 102999141(TGM2) 103003688(TGM1) 103005699(F13A1) 103011508(TGM7) 103017852(TGM3) 103019607(TGM4)
LVE: 103069042(TGM2) 103074098(TGM1) 103076844(TGM4) 103084172(TGM3) 103084459(TGM6) 103084825(TGM7) 103085096(TGM5) 103086768(F13A1)
OOR: 101276821(TGM6) 101277198(TGM2) 101285190(TGM7) 101286489(F13A1) 101288863(TGM1)
ECB: 100053068(TGM3) 100054584(TGM1) 100060428(F13A1) 100067214(TGM6) 100070046(TGM2) 100070842(TGM5) 100630434(TGM7)
EPZ: 103541040(TGM6) 103549243(TGM2) 103556419(TGM7) 103556421(TGM5) 103559774(TGM3) 103560726(F13A1) 103561041(TGM1)
EAI: 106823064(TGM3) 106823069(TGM6) 106832098(F13A1) 106835026(TGM7) 106835027(TGM5) 106835068(TGM2) 106848615(TGM1)
MYB: 102247111(TGM7) 102248755(TGM6) 102249978(TGM1) 102253096(F13A1) 102256943(TGM2) 102261311(TGM3) 102264061(TGM5)
MYD: 102761285(TGM3) 102761564(TGM6) 102762892(TGM7) 102763189(TGM5) 102763968(TGM1) 102766538(F13A1) 102767031(TGM2)
HAI: 109371983(F13A1) 109372134(TGM2) 109383989(TGM7) 109384011(TGM5) 109384367(TGM6) 109384398(TGM3) 109393695(TGM1)
RSS: 109434133(F13A1) 109436132(TGM1) 109444176(TGM5) 109444265(TGM7) 109448421(TGM3) 109448422(TGM6) 109457383(TGM2)
PALE: 102880919(F13A1) 102882668(TGM5) 102882669(TGM7) 102886109(TGM6) 102886354(TGM3) 102892263(TGM1) 102892954(TGM2)
LAV: 100655577(F13A1) 100670898(TGM6) 100674157(TGM2) 100674384(TGM1) 100676143(TGM3) 100676828(TGM5) 100677106(TGM7)
MDO: 100011026(TGM5) 100011115(TGM7) 100020636(F13A1) 100022632(TGM6) 100022686(TGM3) 100030812(TGM1) 100032853(TGM2)
SHR: 100913640(TGM6) 100913906(TGM3) 100918933(TGM1) 100926340(TGM5) 100926605(TGM7) 100930830(TGM2) 100931287(F13A1)
OAA: 100074981(TGM2) 100082527(TGM4)
GGA: 101749664(GGGT5L) 395420(F13A1) 396432(TGM2) 419215(TGM3) 420706(TGM4) 771136(TGM6L) 771144(TGM6)
FPG: 101910367(TGM2) 101913445(TGM3) 101914351 101914530(TGM6) 101914814(F13A1) 101918305(TGM4)
FCH: 102046693(F13A1) 102047927(TGM2) 102053197(TGM3) 102054584(TGM4) 102058624 102058798(TGM6)
ASN: 102371807(TGM4) 102372191 102375112(TGM1) 102380684 102387365(TGM2) 102387520(F13A1) 102387884(TGM3) 102388295(TGM6)
AMJ: 102558174(TGM1) 102560199(TGM4) 102564446(TGM6) 102566325(TGM5) 102566555(TGM3) 102569676(TGM2) 102571839 106736751(F13A1) 109283583
PSS: 102445477(TGM2) 102445996(TGM6) 102446242 102446471 102447904(TGM4) 102451818(TGM5) 102452114(F13A1)
CMY: 102931566(F13A1) 102932100(TGM2) 102932233 102943884(TGM3) 102944102(TGM6) 102944629(TGM1) 102945427(TGM4) 102946418
CPIC: 101931429(TGM5) 101931706 101933169(TGM4) 101937234(F13A1) 101943042(TGM2) 101944405 101950006(TGM1)
PBI: 103048098 103050548(TGM4) 103060917(TGM5) 103062421(TGM1) 103066935(TGM2) 103067398(F13A1) 103067576
XLA: 108695563(tgm1.L) 108701046 108701047 108701049(tgm5.L) 108701795(tgm6.L) 108701796(tgm3.1.L) 108701797 108701798 108701799(tgm3.2.L) 108702205 108702206(tgm3.2.S) 108702207(tgm5.S) 108704915(tgm1.S) 108718499 108718500(tgm4.L) 108719120(f13a1.L) 108720066(f13a1.S) 386605(tgm2) 443836(tgm2-a)
XTR: 100145475(tgm6) 100170618(tgm2) 100485935 100486088(epb42) 100486682(tgm5) 100487465(tgm1) 100488471 100488625(tgm4) 100491279(f13a1) 100498415 594880(tgm3.2)
DRE: 323856(tgm2b) 447909(tgm2a) 559012(tgm2l) 559691(tgm8) 561287(f13a1b) 566581(tgm1l1)
CIN: 100186234 445739(tgm2)
SPU: 578380(etg)
DME: Dmel_CG7356(Tg)
DSI: Dsimw501_GD23497(Dsim_GD23497)
MDE: 101898313
AAG: 5568609
AME: 409425(GB10917) 411132(Tg) 726462
NVI: 100117862
DNX: 107168474
FCD: 110842073
TSP: Tsp_05711
HMG: 100205231
SMIN: v1.2.022434.t1(symbB.v1.2.022434.t1)
DKO: I596_2514
PAE: PA2873
PAEV: N297_2976
PAEI: N296_2976
PAEP: PA1S_11045
PAEM: U769_10585
PAEL: T223_11055
PAEG: AI22_22825
PAEC: M802_2973
PAEO: M801_2841
PMY: Pmen_2448
PMK: MDS_2321
PPSE: BN5_1816
PCQ: PcP3B5_20130(tgpA_1)
PSB: Psyr_2055
PSYR: N018_09545
PSA: PST_1909
PSTT: CH92_08945
PKC: PKB_3686
PSET: THL1_2340
PAR: Psyc_1674
PALI: A3K91_2165
PSYA: AOT82_1221
SON: SO_2150
SDN: Sden_2350
SFR: Sfri_2532
SAZ: Sama_1899
SLO: Shew_2128
SSE: Ssed_1965
SPL: Spea_2418
SHL: Shal_1858
SWD: Swoo_2625
SWP: swp_2766
SVO: SVI_2406
SPSW: Sps_01221
CPS: CPS_2776
PHA: PSHAa1497
PSM: PSM_A1528
PSPO: PSPO_a1643
PART: PARC_a2058
MAQ: Maqu_1575
MAD: HP15_1845
AMAL: I607_07025
AMAE: I876_07320
AMAO: I634_07440
AMAD: I636_07890
AMAI: I635_07800
AMAG: I533_07340
AMAC: MASE_06955
GNI: GNIT_1625
GPS: C427_3214
PIN: Ping_2368
FBL: Fbal_1408
CJA: CJA_1176
SDE: Sde_2067
SAGA: M5M_00655
MICC: AUP74_03228(tgpA)
LOK: Loa_02498
MCA: MCA0466
MEJ: Q7A_1226
MEC: Q7C_647
CYQ: Q91_2248
TEE: Tel_14450
AEH: Mlg_1885
TGR: Tgr7_1489
TKM: TK90_1325
TVR: TVD_05560
GAI: IMCC3135_32330(tgpA_2)
HCH: HCH_02669
HCO: LOKO_00275(tgpA)
HBE: BEI_0478
ABO: ABO_1451
ADI: B5T_02623
APAC: S7S_08290
AXE: P40_12730
KKO: Kkor_1972
KGE: TQ33_0566
TOL: TOL_1546
AHA: AHA_3138
ASA: ASA_1188
AVR: B565_3035
TAU: Tola_3054
DNO: DNO_0839
SLIM: SCL_2806
SVA: SVA_3909
TBN: TBH_C2857
ENM: EBS_2401
CVI: CV_3683
LHK: LHK_02565
PSE: NH8B_0663
RSO: RSp0111
RSE: F504_3562
RPI: Rpic_3856
REH: H16_B0163(h16_B0163)
RME: Rmet_3624
RFR: Rfer_2531
POL: Bpro_3148
PNA: Pnap_1217
AAV: Aave_2161
AJS: Ajs_2816
AAA: Acav_2981
ACRA: BSY15_283
VEI: Veis_2098
DAC: Daci_2384
RTA: Rta_25240
HYB: Q5W_05375
MPT: Mpe_A1243
MMS: mma_2658
JAG: GJA_4068
CFU: CFU_3735
CARE: LT85_4281
LCH: Lcho_2914
TIN: Tint_0768
THI: THI_1007
RGE: RGE_34600
METR: BSY238_493
MFA: Mfla_1839
MEH: M301_1895
MEP: MPQ_1013
SLT: Slit_2223
GCA: Galf_1825
DSU: Dsui_1973
DAR: Daro_2519
AZO: azo1092
AZA: AZKH_3524
AOA: dqs_1202
DGG: DGI_0729
DBA: Dbac_2074
BBA: Bd3883
BBAT: Bdt_3749
BBW: BDW_02285
BBAC: EP01_11895
BMX: BMS_1349
ACU: Atc_0917
BSU: BSU31270(tgl)
BSR: I33_3214(tgl)
BSL: A7A1_2238
BSH: BSU6051_31270(tgl)
BSY: I653_15025(tgl)
BSUT: BSUB_03342(tgl)
BSUL: BSUA_03342(tgl)
BSUS: Q433_17090
BSS: BSUW23_15185(tgl)
BST: GYO_3411(tgl)
BSO: BSNT_09584(tgl)
BSN: BSn5_06500(tgl)
BSQ: B657_31270(tgl)
BSX: C663_2981(tgl)
BLI: BL02523(tgl)
BLD: BLi03298(tgl)
BLH: BaLi_c33790(tgl)
BAY: RBAM_028330(tgl)
BAQ: BACAU_2858(tgl)
BYA: BANAU_3020(tgl)
BAMP: B938_14475(tgl)
BAML: BAM5036_2744(tgl)
BAMA: RBAU_2958(tgl)
BAMN: BASU_2750(tgl)
BAMB: BAPNAU_3007(tgl)
BAMT: AJ82_16020
BAMY: V529_30870(tgl)
BMP: NG74_02978(tgl)
BAO: BAMF_2924(tgl)
BAZ: BAMTA208_15520(tgl)
BQL: LL3_03190(tgl)
BXH: BAXH7_03171(tgl)
BQY: MUS_3406(tgl)
BAMI: KSO_005010(tgl)
BAMC: U471_29300
BAMF: U722_15270
BAE: BATR1942_13460(tgl)
BATR: TD68_12560
BHA: BH3970(tgl)
BAN: BA_4173
BAR: GBAA_4173
BAT: BAS3875(tgl)
BAI: BAA_4198
BANT: A16_41770
BANR: A16R_42300
BANH: HYU01_20415(tgl)
BANV: DJ46_2871(tgl)
BCE: BC3963(tgl)
BCZ: BCE33L3723(tgl)
BCQ: BCQ_3752(tgl)
BCX: BCA_4068
BAL: BACI_c39200(tgl)
BNC: BCN_3863
BCF: bcf_19690
BCER: BCK_15420(tgl)
BTK: BT9727_3708(tgl)
BTL: BALH_3589
BTB: BMB171_C3628(tgl)
BTT: HD73_4248
BTHR: YBT1520_21050(tgl)
BTHI: BTK_20915(tgl)
BTC: CT43_CH3969(tgl)
BTF: YBT020_19475(tgl)
BTM: MC28_3249(tgl)
BTG: BTB_c40960(tgl)
BTI: BTG_29615(tgl)
BTN: BTF1_18115(tgl)
BTHU: YBT1518_21985(tgl)
BTW: BF38_5133(tgl)
BTHY: AQ980_10105(tgl)
BWW: bwei_0990(tgl)
BMYC: DJ92_1055
BMYO: BG05_2062
BCL: ABC2191(tgl)
BPU: BPUM_2792
BPUM: BW16_15145
BPUS: UP12_14740
BPF: BpOF4_04260(tgl)
BMQ: BMQ_2447
BMD: BMD_2424
BMH: BMWSH_2770(tgl)
BMEG: BG04_4823
BJS: MY9_3135
BACI: B1NLA3E_09130(tgl)
BMET: BMMGA3_04935(tgl)
BACW: QR42_14175
BACP: SB24_14585
BACB: OY17_17470
BBY: CY96_18895(tgl)
BACY: QF06_13945
BACL: BS34A_34210(tgl)
BALM: BsLM_3116
BEO: BEH_12900
BGY: BGLY_3692
BKW: BkAM31D_09315(tgl)
GKA: GK2914
GTN: GTNG_2863
GGH: GHH_c29940(tgl)
GEA: GARCT_02944(tgl)
AAMY: GFC30_688
HHD: HBHAL_4227(tgl)
BBE: BBR47_08610(tgl)
PPY: PPE_02788
PPM: PPSC2_14805(tgl)
PPO: PPM_2976(tgl)
PPOL: X809_31215
PPOY: RE92_21910
PMW: B2K_01500
PTA: HPL003_23605(tgl)
PSAB: PSAB_17240(tgl)
PRI: PRIO_0358(tgl)
ASOC: CB4_02754(tgl)
CBO: CBO2291(tgl)
CBA: CLB_2236(tgl)
CBH: CLC_2219(tgl)
CBY: CLM_2599(tgl)
CBL: CLK_1739(tgl)
CBB: CLD_2279(tgl)
CBI: CLJ_B2602(tgl)
CBF: CLI_2345
CBM: CBF_2335
CKL: CKL_0538(tgl)
CKR: CKR_0475
CPAS: Clopa_3523
CPAT: CLPA_c13790(tgl)
CPAE: CPAST_c13790(tgl)
CSQ: CSCA_1223
CTYK: CTK_C02750
CSS: Cst_c03560(tgl)
CSD: Clst_0338
CCEL: CCDG5_0307(tgl)
SYC: syc2217_d
OBG: Verru16b_03571(tgpA)
PLS: VT03_05450(tgpA_2)
SBR: SY1_24230
MPD: MCP_2689
MEZ: Mtc_0300
 » show all
1  [PMID:4151471]
Folk JE, Chung SI.
Molecular and catalytic properties of transglutaminases.
Adv Enzymol Relat Areas Mol Biol 38:109-91 (1973)
2  [PMID:5928192]
Folk JE, Cole PW.
Mechanism of action of guinea pig liver transglutaminase. I. Purification and properties of the enzyme: identification of a functional cysteine essential for activity.
J Biol Chem 241:5518-25 (1966)
3  [PMID:73346]
Folk JE, Finlayson JS.
The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases.
Adv Protein Chem 31:1-133 (1977)
4  [PMID:2877456]
Takahashi N, Takahashi Y, Putnam FW.
Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta.
Proc Natl Acad Sci U S A 83:8019-23 (1986)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 80146-85-6
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