Felis catus (domestic cat): 493967
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Entry
493967 CDS
T02385
Symbol
CYP17A1
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase precursor
KO
K00512
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:
1.14.14.19
1.14.14.32
]
Organism
fca
Felis catus (domestic cat)
Pathway
fca00140
Steroid hormone biosynthesis
fca01100
Metabolic pathways
fca04913
Ovarian steroidogenesis
fca04917
Prolactin signaling pathway
fca04927
Cortisol synthesis and secretion
fca04934
Cushing syndrome
Module
fca_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
fca_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
fca_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
fca_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
fca00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
493967 (CYP17A1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
493967 (CYP17A1)
04917 Prolactin signaling pathway
493967 (CYP17A1)
04927 Cortisol synthesis and secretion
493967 (CYP17A1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
493967 (CYP17A1)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:
fca00199
]
493967 (CYP17A1)
Enzymes [BR:
fca01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.19 steroid 17alpha-monooxygenase
493967 (CYP17A1)
1.14.14.32 17alpha-hydroxyprogesterone deacetylase
493967 (CYP17A1)
Cytochrome P450 [BR:
fca00199
]
Cytochrome P450, animal type
CYP17 family
493967 (CYP17A1)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
p450
Motif
Other DBs
NCBI-GeneID:
493967
NCBI-ProteinID:
NP_001009371
EnsemblRapid:
ENSFCTG00005011139
UniProt:
Q9GMC8
LinkDB
All DBs
Position
D2:complement(61041655..61047383)
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AA seq
508 aa
AA seq
DB search
MWELLVFLLFAVAYFLWPKAKCPGAKYPKSLPSLPLVGSLLFLPRSGHPHKNFFKLQKKY
GPIYSFRLGTKTTVMVGDHQLAKEVLVKKGKEFSGRPHVVTLDILSDNQKGIAFADHGAS
WQMHRKLALATFALFKDGDQRLEKIICREISLLCDNLAMQDGQSIDLYLPLFLAVTNIIC
LICFNSSFKNGDPALKIIQNYNEGILKTLGKDNLVDIFPVLKIFPNKTLEKMKNYVKNRD
ELLREILEKHKENFSNDSITNMLDVLIQARMNSDNNGAASDQDSKLLSDKHILTTIGDIF
GAGVETTTSVVRWTVAFLLHHPQLYKKLQEEIDQNIGFSRTPTMSDRNQLILLEATIREV
LRIRPVAPTLIPHKAIMDSSIGEFAVDKGTNVIINLWALHHNEKEWYRPDQFMPERFLDP
TRSQLISPSLSYLPFGAGPRSCLGESLARQEVFLFMAWLLQRFDLEVPDDGQLPHLEGNP
TVVFLIAPFKVKVKVRQAWREAQAEGST
NT seq
1527 nt
NT seq
+upstream
nt +downstream
nt
atgtgggagctcttggttttcttgctgttcgccgtagcctatttcttgtggcccaaggca
aagtgccctggtgccaagtatcccaagagcctcccatccctgcccttggtgggcagcctg
ctattcctccccagaagtggtcatccacacaagaacttcttcaagctgcagaaaaaatac
ggccccatctattcctttcgtctggggaccaagactacagtgatggtcggtgaccaccag
ctggccaaggaggtgcttgtcaagaagggcaaggaattctctgggcggccccatgtggtg
actctggatatcctgtctgacaaccaaaagggcattgcctttgccgaccatggtgccagc
tggcagatgcacaggaagctggcactggccacctttgccctgttcaaggatggcgaccaa
aggctagagaagatcatttgtcgggaaatcagtttattgtgtgataacctggccatgcag
gatggacagtccatagatttgtacttgcctctcttcctggcggtgaccaacatcatctgc
ttgatctgcttcaactcctccttcaagaatggagatcctgctctgaagatcatacagaat
tacaatgaaggcatcttgaaaactttgggaaaggacaatttggtagacatattccccgtg
ttgaagattttccccaacaaaaccttggaaaaaatgaagaattatgttaaaaaccgagat
gagttgctgagagaaatccttgaaaaacataaggagaacttcagcaatgactctatcacc
aacatgctggatgtactgatccaagccaggatgaactcagacaataacggtgctgcctca
gaccaggattcgaagctgctttcggataaacacatccttaccaccataggggacatcttt
ggggctggtgtggagaccaccacatccgtggtgaggtggactgtggccttcctgttacac
catcctcagttgtataagaagctccaggaggagattgaccagaatataggtttcagccgc
acgccaactatgagtgaccggaatcaactcatcttgctagaggccaccatccgagaggtg
cttcgcatccggcctgtggcccctacgctcatcccccacaaggctatcatggattctagc
attggcgagtttgctgttgacaagggcacaaatgttatcatcaatttgtgggcactgcat
cacaatgagaaggagtggtaccggcccgaccagttcatgcccgaacgcttcttggacccc
acgaggagtcagctcatctcgccatcattaagttacttgccctttggagcaggaccccgc
tcctgcctaggtgagagcctggcccgccaggaggtcttcctcttcatggcctggttgctg
cagaggtttgacctggaggtcccggatgatgggcagctgccccacctggaaggcaacccc
acggtggtctttttgattgcgcctttcaaagtgaaggtgaaggtacgccaggcctggagg
gaagcccaggctgagggtagcacctaa
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