KEGG   Gracilinanus agilis (agile gracile opossum): 123250672
Entry
123250672         CDS       T07702                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
gas  Gracilinanus agilis (agile gracile opossum)
Pathway
gas01522  Endocrine resistance
gas04010  MAPK signaling pathway
gas04015  Rap1 signaling pathway
gas04068  FoxO signaling pathway
gas04071  Sphingolipid signaling pathway
gas04114  Oocyte meiosis
gas04148  Efferocytosis
gas04218  Cellular senescence
gas04261  Adrenergic signaling in cardiomyocytes
gas04370  VEGF signaling pathway
gas04380  Osteoclast differentiation
gas04550  Signaling pathways regulating pluripotency of stem cells
gas04611  Platelet activation
gas04613  Neutrophil extracellular trap formation
gas04620  Toll-like receptor signaling pathway
gas04621  NOD-like receptor signaling pathway
gas04622  RIG-I-like receptor signaling pathway
gas04625  C-type lectin receptor signaling pathway
gas04657  IL-17 signaling pathway
gas04658  Th1 and Th2 cell differentiation
gas04659  Th17 cell differentiation
gas04660  T cell receptor signaling pathway
gas04664  Fc epsilon RI signaling pathway
gas04668  TNF signaling pathway
gas04670  Leukocyte transendothelial migration
gas04714  Thermogenesis
gas04722  Neurotrophin signaling pathway
gas04723  Retrograde endocannabinoid signaling
gas04728  Dopaminergic synapse
gas04750  Inflammatory mediator regulation of TRP channels
gas04912  GnRH signaling pathway
gas04914  Progesterone-mediated oocyte maturation
gas04917  Prolactin signaling pathway
gas04926  Relaxin signaling pathway
gas04932  Non-alcoholic fatty liver disease
gas04933  AGE-RAGE signaling pathway in diabetic complications
gas04935  Growth hormone synthesis, secretion and action
gas04936  Alcoholic liver disease
gas05014  Amyotrophic lateral sclerosis
gas05020  Prion disease
gas05022  Pathways of neurodegeneration - multiple diseases
gas05132  Salmonella infection
gas05133  Pertussis
gas05135  Yersinia infection
gas05140  Leishmaniasis
gas05142  Chagas disease
gas05145  Toxoplasmosis
gas05152  Tuberculosis
gas05161  Hepatitis B
gas05163  Human cytomegalovirus infection
gas05167  Kaposi sarcoma-associated herpesvirus infection
gas05169  Epstein-Barr virus infection
gas05170  Human immunodeficiency virus 1 infection
gas05171  Coronavirus disease - COVID-19
gas05205  Proteoglycans in cancer
gas05208  Chemical carcinogenesis - reactive oxygen species
gas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
gas05415  Diabetic cardiomyopathy
gas05417  Lipid and atherosclerosis
gas05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:gas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123250672 (MAPK12)
   04015 Rap1 signaling pathway
    123250672 (MAPK12)
   04370 VEGF signaling pathway
    123250672 (MAPK12)
   04668 TNF signaling pathway
    123250672 (MAPK12)
   04068 FoxO signaling pathway
    123250672 (MAPK12)
   04071 Sphingolipid signaling pathway
    123250672 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    123250672 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    123250672 (MAPK12)
   04218 Cellular senescence
    123250672 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    123250672 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123250672 (MAPK12)
   04613 Neutrophil extracellular trap formation
    123250672 (MAPK12)
   04620 Toll-like receptor signaling pathway
    123250672 (MAPK12)
   04621 NOD-like receptor signaling pathway
    123250672 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    123250672 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    123250672 (MAPK12)
   04660 T cell receptor signaling pathway
    123250672 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    123250672 (MAPK12)
   04659 Th17 cell differentiation
    123250672 (MAPK12)
   04657 IL-17 signaling pathway
    123250672 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    123250672 (MAPK12)
   04670 Leukocyte transendothelial migration
    123250672 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    123250672 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    123250672 (MAPK12)
   04917 Prolactin signaling pathway
    123250672 (MAPK12)
   04926 Relaxin signaling pathway
    123250672 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    123250672 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123250672 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    123250672 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    123250672 (MAPK12)
   04722 Neurotrophin signaling pathway
    123250672 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123250672 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123250672 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    123250672 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    123250672 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    123250672 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123250672 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    123250672 (MAPK12)
   05161 Hepatitis B
    123250672 (MAPK12)
   05171 Coronavirus disease - COVID-19
    123250672 (MAPK12)
   05163 Human cytomegalovirus infection
    123250672 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123250672 (MAPK12)
   05169 Epstein-Barr virus infection
    123250672 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123250672 (MAPK12)
   05135 Yersinia infection
    123250672 (MAPK12)
   05133 Pertussis
    123250672 (MAPK12)
   05152 Tuberculosis
    123250672 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    123250672 (MAPK12)
   05140 Leishmaniasis
    123250672 (MAPK12)
   05142 Chagas disease
    123250672 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    123250672 (MAPK12)
   05020 Prion disease
    123250672 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    123250672 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123250672 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    123250672 (MAPK12)
   05415 Diabetic cardiomyopathy
    123250672 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    123250672 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    123250672 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123250672 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    123250672 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:gas01001]
    123250672 (MAPK12)
Enzymes [BR:gas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     123250672 (MAPK12)
Protein kinases [BR:gas01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   123250672 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 RIO1 APH Kdo Kinase-like Haspin_kinase UvrD_C FTA2
Other DBs
NCBI-GeneID: 123250672
NCBI-ProteinID: XP_044535799
LinkDB
Position
5:complement(305863268..305881714)
AA seq 349 aa
MSSPPPPRKGFYRQEVTKTAWEVRELYRDLQPVGSGAYGAVCSAIDSRTGTKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDDTLDDFTDFYLVMPFMGTDLSKLM
KHEQLSDDRIQFLVYQILRGLKYIHAAGIVHRDLKPGNLAVNEDCELKILDFGLARQTDS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGSDHLDQLMEIMK
VTGTPPPEFVQRLQSQDAKNYMENLPELEKKDFASILKNAPPLAVNLLEKMLVLDAEKRV
TAAEALTHPYFETVHESEEEPKAQLYDDSFDDVDRTLEEWKRESWPSMP
NT seq 1050 nt   +upstreamnt  +downstreamnt
atgagttcccctccgcccccccggaagggcttttaccggcaggaggtcactaagacagct
tgggaggtgcgggaactctaccgcgacctgcagcccgtgggctctggggcttacggggcc
gtgtgctcggccattgacagcaggaccggcaccaaggtggccatcaagaagctgtaccgt
cccttccagtcggagctgttcgccaagcgcgcctaccgggagctgcggctgctcaaacac
atgcgccacgagaacgtgattggcctactggatgtcttcaccccggatgacacactggat
gacttcacagacttttacctggtcatgccgttcatgggcaccgatctcagcaagctgatg
aaacatgagcagctcagcgatgaccggatccagttcttggtttaccagattcttcggggg
ctcaagtacatccatgctgctggcatcgtccacagggatctcaaacccggtaacctggca
gtgaatgaggactgtgagctgaagattctggactttggcctggccagacagacagacagt
gagatgactggctacgtggtgaccagatggtaccgggcacctgaggtcatcctcaactgg
atgcgttacacacagacagtggacatctggtctgtgggctgcatcatggcagagatgatc
actggaaagatccttttcaaagggagtgaccacctggaccagctgatggagatcatgaag
gtgacggggacacctccccccgagtttgtgcagcgcctccagagtcaggatgccaagaac
tacatggagaatctcccagagctggagaagaaggactttgcctccatcctgaagaacgcg
ccccccctggctgtgaacctgctcgagaagatgttggtactggatgccgagaagcgagtg
acagctgccgaggcgctgactcacccctactttgagactgtgcatgaatccgaggaggag
cccaaggcccagctctacgatgactccttcgacgacgttgaccggaccttggaggagtgg
aaacgtgagtcctggccttccatgccctga

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