Gallus gallus (chicken): 421894
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Entry
421894 CDS
T01006
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
gga
Gallus gallus (chicken)
Pathway
gga00270
Cysteine and methionine metabolism
gga00480
Glutathione metabolism
gga01100
Metabolic pathways
gga01240
Biosynthesis of cofactors
gga04216
Ferroptosis
Module
gga_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
gga00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
421894 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
421894 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
421894 (GCLC)
Enzymes [BR:
gga01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
421894 (GCLC)
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GFIT
Motif
Pfam:
GCS
GCS2
SANT_DAMP1_like
Motif
Other DBs
NCBI-GeneID:
421894
NCBI-ProteinID:
XP_419910
CGNC:
12202
Ensembl:
ENSGALG00000016313
UniProt:
F1NQZ9
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Position
3:88184018..88216693
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AA seq
636 aa
AA seq
DB search
MGLLSQGSPLSWEETRRHAEHVRKHGILQFLHIYRALRDRHKDVLKWGDEVEYMLVKFDH
ENKKVRLVLSGEEVLQTLQDKGEKINPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
QDNMRKRRQEAASVLKENEAVCTVTSFPRLGCPGFTLPEYKPTPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPNDDGEAAKAAKPDFIYMD
AMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGV
ISASVDDRTREERGLEPLKNNHYRISKSRYDSIDSYLSECGEKYNDIDLTIDKDIYEHLI
KEGIDHLLAQHIAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSD
IGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAV
RQGMFYFRKDICKGGNVVVDGCGSAQNGTGTDTEEYTLMSIDTIINGKEGVFPGLIPILN
SYLENMEVDVDTRCTILNYLKLIKKRASGELMTVARWMREFIAQHPDYKQDSVITDEMNY
SLIWKCNQIAQGQAECPELLGVAFNKKPSGNKTDPL
NT seq
1911 nt
NT seq
+upstream
nt +downstream
nt
atggggttgctgtcgcagggctcgccgctgagctgggaggagacgcggcggcacgcggag
cacgtgcggaagcacggcatcctccagttcctccacatctatcgcgcgctgcgcgaccgc
cacaaggacgtccttaagtggggcgatgaggtggagtacatgttagtaaaatttgaccat
gagaataagaaagtacgcttagtgctgagtggcgaagaagttcttcaaacgctgcaagac
aagggggagaagataaaccccaaccacccaacactctggcgaccagaatatggaagctat
atgattgaaggcacacctgggcagccatatgggggaaccatgtcggaattcaacactgtt
caagacaacatgaggaagaggaggcaagaggctgcttctgtgctgaaagaaaatgaggct
gtttgcactgtgacatcttttccaaggttagggtgtcccggatttacgctgccggaatat
aagccaacgccagtggaaggaggagcttcaaaatccctcttctttccagatgaagccatc
aataaacatcctagatttagtacactgaccagaaacattcggcaccgaagaggagagaag
gttgtcataaatgtaccaatttttaaagataagaatacaccatcaccatttatagaaaca
tttcctaatgatgatggagaagcagcaaaagcagcgaagccagacttcatatatatggac
gctatggggtttggaatgggcaactgctgtcttcaggtaacattccaggcttgcagcatt
tctgaagcaagatatctctatgatcagctagccacaatctgtcccattgtgatggccttg
agcgctgcatctccgttctacagaggctatgtgtccgatattgattgtcgctggggagta
atatctgcatctgtagatgatcgaacgcgagaagagcgggggctagagccactgaagaac
aaccattatagaatcagtaaatccagatatgattccatagacagttatctatctgaatgt
ggtgaaaaatacaatgacattgatttgacaatagacaaagatatctacgagcacctaata
aaggaaggtattgaccaccttttggcacagcatattgcacacttgtttattcgagaccca
ttgactttgtttgaggagaaaatacatctagatgatgcaaatgaatccgaccattttgag
aatattcagtctacaaactggcagacaatgagatttaaaccaccccctccaaattcagat
ataggatggagagtggaattcaggcctatggaggtccagttaacagactttgaaaactct
gcatatgttgtgtttgtggtactgctaactcgagtgattctgtcatacaaactggatttt
ctcattcctttgtccaaggtggatgaaaatatgaaggtggcccagaaaagagatgctgtt
cggcagggaatgttttacttcagaaaggatatttgcaaaggtggaaatgtcgttgtggat
ggatgcggttctgcacaaaatgggacaggcacagacacagaagagtacaccttaatgagc
atcgatacaattataaacgggaaggaaggagtctttcctggtttgatcccgattttgaat
tcttaccttgaaaacatggaggtggatgtggacacaagatgcaccatcctaaactacctg
aagttaataaaaaagagagcatctggagaattaatgacagtcgcccgatggatgagggaa
ttcatcgcacagcacccagactacaagcaggatagcgtgataacagatgaaatgaattac
agcctcatttggaaatgcaaccaaatcgcacaaggccaggcagaatgtccagaactgttg
ggggtagcatttaacaagaagccaagtggaaacaaaactgaccctttgtaa
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