KEGG   Heterocephalus glaber (naked mole rat): 101704397
Entry
101704397         CDS       T02812                                 

Gene name
Tgfbr2
Definition
(RefSeq) transforming growth factor beta receptor 2
  KO
K04388  TGF-beta receptor type-2 [EC:2.7.11.30]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
hgl04010  MAPK signaling pathway
hgl04060  Cytokine-cytokine receptor interaction
hgl04068  FoxO signaling pathway
hgl04144  Endocytosis
hgl04218  Cellular senescence
hgl04350  TGF-beta signaling pathway
hgl04380  Osteoclast differentiation
hgl04390  Hippo signaling pathway
hgl04520  Adherens junction
hgl04659  Th17 cell differentiation
hgl04926  Relaxin signaling pathway
hgl04933  AGE-RAGE signaling pathway in diabetic complications
hgl05142  Chagas disease
hgl05161  Hepatitis B
hgl05166  Human T-cell leukemia virus 1 infection
hgl05200  Pathways in cancer
hgl05202  Transcriptional misregulation in cancer
hgl05210  Colorectal cancer
hgl05212  Pancreatic cancer
hgl05220  Chronic myeloid leukemia
hgl05225  Hepatocellular carcinoma
hgl05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101704397 (Tgfbr2)
   04350 TGF-beta signaling pathway
    101704397 (Tgfbr2)
   04390 Hippo signaling pathway
    101704397 (Tgfbr2)
   04068 FoxO signaling pathway
    101704397 (Tgfbr2)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    101704397 (Tgfbr2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    101704397 (Tgfbr2)
  09143 Cell growth and death
   04218 Cellular senescence
    101704397 (Tgfbr2)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    101704397 (Tgfbr2)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    101704397 (Tgfbr2)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    101704397 (Tgfbr2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101704397 (Tgfbr2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101704397 (Tgfbr2)
   05202 Transcriptional misregulation in cancer
    101704397 (Tgfbr2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101704397 (Tgfbr2)
   05212 Pancreatic cancer
    101704397 (Tgfbr2)
   05225 Hepatocellular carcinoma
    101704397 (Tgfbr2)
   05226 Gastric cancer
    101704397 (Tgfbr2)
   05220 Chronic myeloid leukemia
    101704397 (Tgfbr2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101704397 (Tgfbr2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101704397 (Tgfbr2)
   05161 Hepatitis B
    101704397 (Tgfbr2)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    101704397 (Tgfbr2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101704397 (Tgfbr2)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     101704397 (Tgfbr2)
Protein kinases [BR:hgl01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   101704397 (Tgfbr2)
SSDB
Motif
Pfam: ecTbetaR2 PK_Tyr_Ser-Thr Pkinase Pkinase_fungal APH
Other DBs
NCBI-GeneID: 101704397
NCBI-ProteinID: XP_004857873
LinkDB
Position
Un
AA seq 611 aa
MGRRLLRGLWPLHIVLWTRIASTIPPQVQKSGSERQIIRRDLAAEQVPMTDMEVEARKDE
TIFLSCNRTIHSLNLFNNDMMATETNGAVKFSQLCKFCDVRSSTCDNQKSCMSNCSITSI
CEKSHEVCVAVWRKNDENITLETVCHDPELPYHGFILEDATSLKCIMKEKKVLGETFFMC
SCSADECNDHIIFSEEYAASSPDLWLVIFQVTGVSLLPPLGIAIAVIIIFYCYRVHRQQK
LSPSWESSKPRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFA
EVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTE
LGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIV
HRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNL
ENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRG
RPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSRRSCSEEK
IPEDGSLNTTK
NT seq 1836 nt   +upstreamnt  +downstreamnt
atgggtcggcggctgctccggggcctgtggccgctgcacatcgtcctgtggacgcgcatc
gccagcacgatcccaccgcaagttcagaagtcggggtcagagcgacaaatcatcagaagg
gatttagctgcagagcaagtgcctatgactgatatggaagtggaggcccggaaagatgaa
accatcttcttaagctgtaataggaccattcattcactgaacctgtttaataatgacatg
atggccaccgaaacgaatggtgcagtcaagttttcacaactctgcaaattttgtgatgtg
agatcttccacctgtgacaaccagaaatcctgcatgagcaactgcagcatcacatccatc
tgtgagaagtcacatgaagtctgtgtggccgtatggcggaagaatgacgagaacataaca
ctagagacggtttgccatgaccctgagctcccctaccatggatttattctggaagatgct
acttcgttgaagtgcattatgaaggaaaaaaaagtgcttggcgagactttctttatgtgc
tcctgtagtgctgatgaatgcaacgaccacatcatcttctcagaagaatatgctgcaagc
agtcctgacttgtggttagtcatattccaagtgacaggagtcagtcttctgccgcctctg
ggaatcgccatagctgtcatcattattttctactgctaccgtgttcaccggcagcagaag
ctgagcccatcctgggagagtagcaagccacgaaagctcatggagttcagtgagcactgt
gccatcattctggaagatgaccgctctgacatcagctccacatgtgccaataacatcaac
cacaacacggagctcctgcccatcgagctggacacactggtgggcaaaggccgcttcgct
gaggtttacaaggccaagttgaagcagaacacttcagagcagttcgagactgtagcagtc
aagatcttcccctatgaggagtatgcctcttggaagacagagaaagacatcttctcagac
atcaacctgaagcatgagaatatcctccagtttctcacagctgaggaacggaagacagag
ttggggaaacagtactggttgatcactgccttccatgccaagggcaaccttcaggagtac
ctcacccggcatgtcatcagctgggaggacctgcgcaagttgggcagttcccttgcccgg
ggcatcgcccacctccatagtgaccacacaccatgtgggagacctaaaatgcccatcgtg
cacagagatctcaagagctccaacatcctcgtgaagaatgatctgacctgctgcctctgc
gactttgggctttccctgcgtctggaccctactctgtctgtagatgacctggccaacagt
gggcaggtgggaactgcaagatacatggccccagaagtcctggaatccaggatgaacttg
gagaatgttgagtccttcaagcagaccgatgtttactctatggctttggtgctctgggaa
atgacatctcgctgtaatgctgtgggagaggtaaaagattatgagcctccatttggttcc
aaggtgcgggagcacccttgtgttgagagcatgaaggacaatgtgttaagagacagagga
cgaccagaaattcccagcttctggctcaaccaccagggcatccagatggtgtgtgagaca
ctgacagagtgctgggaccacgacccagaggcgcgtctcacggcccaatgtgtggcggaa
cgctttagcgagctggagcacctggacagactctcccggaggagctgctcggaggagaag
attcccgaagatggctcgctgaacactaccaaatag

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