KEGG   VARIANT: 1956v1Help
Entry
1956v1                      Variant                                

Name
EGFR amplification
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 59680 59682
dbVar: nsv532206 nsv532208
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06220  Calcium signaling
nt06265  Bladder cancer
nt06273  Glioma
  Element
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
Reference
  Authors
Miller JJ, Wen PY
  Title
Emerging targeted therapies for glioma.
  Journal
Expert Opin Emerg Drugs 21:441-452 (2016)
DOI:10.1080/14728214.2016.1257609
Reference
  Authors
Szerlip NJ, Pedraza A, Chakravarty D, Azim M, McGuire J, Fang Y, Ozawa T, Holland EC, Huse JT, Jhanwar S, Leversha MA, Mikkelsen T, Brennan CW
  Title
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response.
  Journal
Proc Natl Acad Sci U S A 109:3041-6 (2012)
DOI:10.1073/pnas.1114033109
Reference
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
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