KEGG   ORTHOLOGY: K00509Help
Entry
K00509                      KO                                     

Name
PTGS1, COX1
Definition
prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]
Pathway
ko00590  Arachidonic acid metabolism
ko01100  Metabolic pathways
ko04611  Platelet activation
ko04726  Serotonergic synapse
ko04923  Regulation of lipolysis in adipocytes
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00590 Arachidonic acid metabolism
    K00509  PTGS1, COX1; prostaglandin-endoperoxide synthase 1
 Organismal Systems
  Immune system
   04611 Platelet activation
    K00509  PTGS1, COX1; prostaglandin-endoperoxide synthase 1
  Endocrine system
   04923 Regulation of lipolysis in adipocyte
    K00509  PTGS1, COX1; prostaglandin-endoperoxide synthase 1
  Nervous system
   04726 Serotonergic synapse
    K00509  PTGS1, COX1; prostaglandin-endoperoxide synthase 1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     K00509  PTGS1, COX1; prostaglandin-endoperoxide synthase 1
BRITE hierarchy
Other DBs
RN: R00073 R01590
GO: 0004666
Genes
HSA: 5742(PTGS1)
PTR: 464713(PTGS1)
PPS: 100993705(PTGS1)
GGO: 101141060(PTGS1)
PON: 100437175(PTGS1)
NLE: 100585600(PTGS1)
MCC: 698213(PTGS1)
MCF: 102144094(PTGS1)
CSAB: 103218890(PTGS1)
RRO: 104655861(PTGS1)
RBB: 108537103(PTGS1)
CJC: 100393715(PTGS1)
SBQ: 101033759(PTGS1)
MMU: 19224(Ptgs1)
RNO: 24693(Ptgs1)
CGE: 100770867(Ptgs1)
NGI: 103734478(Ptgs1)
HGL: 101698854(Ptgs1)
CCAN: 109692474(Ptgs1)
OCU: 100009407(PTGS1)
TUP: 102497535(PTGS1)
CFA: 403544(PTGS1)
AML: 100481235(PTGS1)
UMR: 103670355(PTGS1)
ORO: 101370362(PTGS1)
FCA: 101092557(PTGS1)
PTG: 102964670(PTGS1)
AJU: 106986637(PTGS1)
BTA: 282022(PTGS1)
BOM: 102287995(PTGS1)
BIU: 109566428(PTGS1)
PHD: 102319508(PTGS1)
CHX: 102170328(PTGS1)
OAS: 443551(PTGS1)
SSC: 397541(PTGS1)
CFR: 102507716(PTGS1)
CDK: 105104317(PTGS1)
BACU: 103003952(PTGS1)
LVE: 103070077(PTGS1)
OOR: 101274585(PTGS1)
ECB: 100034087(PTGS1)
EPZ: 103555394(PTGS1)
EAI: 106842002(PTGS1)
MYB: 102259554(PTGS1)
MYD: 102755037(PTGS1)
HAI: 109374968(PTGS1)
RSS: 109447178(PTGS1)
PALE: 102889003(PTGS1)
LAV: 100653633(PTGS1)
TMU: 101353557
MDO: 100016853
SHR: 100914094
OAA: 100081492(PTGS1)
GGA: 427752(PTGS1)
MGP: 100549847(PTGS1)
CJO: 107321839(PTGS1)
APLA: 101798526(PTGS1)
ACYG: 106040639(PTGS1)
TGU: 100226968(PTGS1)
GFR: 102035566(PTGS1)
FAB: 101806256(PTGS1)
PHI: 102109794(PTGS1)
PMAJ: 107211923(PTGS1)
CCW: 104688375(PTGS1)
FPG: 101919862(PTGS1)
FCH: 102046609(PTGS1)
CLV: 102088222(PTGS1)
EGZ: 104135209(PTGS1)
AAM: 106495973(PTGS1)
ASN: 102386481(PTGS1)
AMJ: 102567925(PTGS1)
PSS: 102456040
CMY: 102933336(PTGS1)
CPIC: 101945575(PTGS1)
ACS: 100558584(ptgs1)
PVT: 110078807(PTGS1)
PBI: 103060436(PTGS1)
GJA: 107116524(PTGS1)
XLA: 100037245(ptgs1.S)
XTR: 100493073(ptgs1)
NPR: 108805018(PTGS1)
DRE: 246226(ptgs1)
IPU: 108255976
AMEX: 103025268(ptgs1)
LCO: 104923661 104924489(ptgs1)
SASA: 100195345(pgh1) 106585418
ELS: 105014126
SFM: 108936098(ptgs1) 108938933
LCM: 102361862(PTGS1)
CMK: 103184666(ptgs1)
MGR: MGG_10859
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Rouzer CA, Marnett LJ
  Title
Cyclooxygenases: structural and functional insights.
  Journal
J Lipid Res 50 Suppl:S29-34 (2009)
DOI:10.1194/jlr.R800042-JLR200
Reference
PMID:3125548
  Authors
DeWitt DL, Smith WL
  Title
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
  Journal
Proc Natl Acad Sci U S A 85:1412-6 (1988)
DOI:10.1073/pnas.85.5.1412
  Sequence
[oas:443551]
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