KEGG ORTHOLOGY: K09637

ORTHOLOGY: K09637

Entry

K09637                      KO

Symbol

TMPRSS6

Name

transmembrane protease serine 6 [EC:3.4.21.-]

Disease

H01278

Iron-refractory iron deficiency anemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K09637  TMPRSS6; transmembrane protease serine 6
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K09637  TMPRSS6; transmembrane protease serine 6

Genes

HSA:	164656(TMPRSS6)

PTR:	458805(TMPRSS6)

PPS:	100991084(TMPRSS6)

GGO:	101138107(TMPRSS6)

PON:	100460608(TMPRSS6)

NLE:	100581044(TMPRSS6)

HMH:	116458673(TMPRSS6)

MCC:	696094(TMPRSS6)

MCF:	102139590(TMPRSS6)

MTHB:

126963705

MNI:	105464499(TMPRSS6)

CSAB:

103223267(TMPRSS6)

CATY:

105575814(TMPRSS6)

PANU:

101013972(TMPRSS6)

TGE:	112633274(TMPRSS6)

MLEU:

105538907(TMPRSS6)

RRO:	104682497(TMPRSS6)

RBB:	108512724(TMPRSS6)

TFN:	117069998 117096515(TMPRSS6)

PTEH:

111549079(TMPRSS6)

CANG:

105527811(TMPRSS6)

CJC:	100394553(TMPRSS6)

SBQ:	101031384(TMPRSS6)

CIMI:

108289464(TMPRSS6)

CSYR:

103258831(TMPRSS6)

MMUR:

105883736(TMPRSS6)

LCAT:

123639297(TMPRSS6)

PCOQ:

105805208(TMPRSS6)

OGA:	100958128(TMPRSS6)

MMU:	71753(Tmprss6)

MCAL:

110310168(Tmprss6)

MPAH:

110334977(Tmprss6)

RNO:	315388(Tmprss6)

MCOC:

116075420(Tmprss6)

ANU:	117718737(Tmprss6)

MUN:	110548467(Tmprss6)

CGE:	100762768(Tmprss6)

MAUA:

101831200(Tmprss6)

PROB:

127225751(Tmprss6)

PLEU:

114694228(Tmprss6)

MORG:

121461160(Tmprss6)

MFOT:

126515705

AAMP:

119824004(Tmprss6)

NGI:	103748620(Tmprss6)

HGL:	101726737(Tmprss6)

CPOC:

100730361(Tmprss6)

CCAN:

109698252(Tmprss6)

DORD:

105992036(Tmprss6)

DSP:	122119236(Tmprss6)

PLOP:

125353764(Tmprss6)

NCAR:

124982498

MMMA:

107139663(Tmprss6)

OCU:

127490197

OPI:	101532873(TMPRSS6)

TUP:	102503001(TMPRSS6)

GVR:	103602073(TMPRSS6)

CFA:	608593(TMPRSS6)

CLUD:

112668472(TMPRSS6)

VVP:	112929100(TMPRSS6)

VLG:	121490388(TMPRSS6)

NPO:	129511825(TMPRSS6)

AML:	100468980(TMPRSS6)

UMR:	103676412(TMPRSS6)

UAH:	113255955(TMPRSS6)

UAR:	123780841(TMPRSS6)

ELK:

111157540

LLV:

125106147

MPUF:

101677828(TMPRSS6)

MNP:	132019256(TMPRSS6)

MLK:	131839434(TMPRSS6)

NVS:	122891616(TMPRSS6)

ORO:	101387010(TMPRSS6)

EJU:	114218338(TMPRSS6)

ZCA:	113922591(TMPRSS6)

MLX:	117998720(TMPRSS6)

NSU:	110578108(TMPRSS6)

LWW:	102733101(TMPRSS6)

FCA:	101092375(TMPRSS6)

PYU:	121026677 121026679

PCOO:

112863354(TMPRSS6)

PBG:	122472703(TMPRSS6)

PVIV:

125170778(TMPRSS6)

LRUF:

124501004

PTG:	102962212(TMPRSS6)

PPAD:

109265526(TMPRSS6)

PUC:

125919565

AJU:

106981028

HHV:	120241148(TMPRSS6)

BTA:	614844(TMPRSS6)

BOM:	102278375(TMPRSS6)

BIU:	109558530 109559532(TMPRSS6)

BBUB:

102391322(TMPRSS6)

BBIS:

105003411(TMPRSS6)

CHX:	102178888(TMPRSS6)

OAS:	101102553(TMPRSS6)

BTAX:

128048497(TMPRSS6)

ODA:	120858562 120861187

CCAD:

122423964(TMPRSS6)

MBEZ:

129536324(TMPRSS6)

SSC:	100516673(TMPRSS6)

CFR:	102519836(TMPRSS6)

CBAI:

105073157(TMPRSS6)

CDK:	105101577(TMPRSS6)

VPC:	102541222(TMPRSS6)

BACU:

103008188(TMPRSS6)

BMUS:

118902226(TMPRSS6)

LVE:	103077358(TMPRSS6)

OOR:	101290328(TMPRSS6)

DLE:	111186274(TMPRSS6)

PCAD:

102991591 114485200

PSIU:

116760807(TMPRSS6)

NASI:

112410815(TMPRSS6)

ECB:	100069647(TMPRSS6)

EPZ:	103542657(TMPRSS6)

EAI:	106837579(TMPRSS6)

MYB:	102241421(TMPRSS6)

MYD:	102752236(TMPRSS6)

MMYO:

118651129(TMPRSS6)

MLF:	102417077(TMPRSS6)

PKL:	118730451(TMPRSS6)

EFUS:

103288896(TMPRSS6)

MNA:	107545302(TMPRSS6)

DRO:	112321714(TMPRSS6)

SHON:

119002322(TMPRSS6)

AJM:	119060315(TMPRSS6)

PDIC:

114513455(TMPRSS6)

PHAS:

123816269(TMPRSS6)

MMF:	118624179(TMPRSS6)

PPAM:

129071323(TMPRSS6)

HAI:	109394513(TMPRSS6)

RFQ:	117029313(TMPRSS6)

PALE:

102884593(TMPRSS6) 102885180

PGIG:

120614852(TMPRSS6)

PVP:	105288309(TMPRSS6)

RAY:	107519304(TMPRSS6)

MJV:	108392660(TMPRSS6)

TOD:	119248241(TMPRSS6)

SARA:

101539864(TMPRSS6)

SETR:

126006211(TMPRSS6)

LAV:	100669423(TMPRSS6)

TMU:

101344116

ETF:	101664417(TMPRSS6)

DNM:	101421062(TMPRSS6)

MDO:	100025330(TMPRSS6)

SHR:	100935245(TMPRSS6)

AFZ:

127538168

PCW:	110205741(TMPRSS6)

OAA:	100092848(TMPRSS6)

GGA:	418046(TMPRSS6)

PCOC:

116233234(TMPRSS6)

MGP:	100538769(TMPRSS6)

CJO:	107313761(TMPRSS6)

TPAI:

128073634(TMPRSS6)

LMUT:

125699585(TMPRSS6)

NMEL:

110393208(TMPRSS6)

APLA:

101792037(TMPRSS6)

ACYG:

106035770(TMPRSS6)

CATA:

118250666(TMPRSS6)

AFUL:

116501560(TMPRSS6)

TGU:	100220511(TMPRSS6)

LSR:	110483868(TMPRSS6)

SCAN:

103813229(TMPRSS6)

PMOA:

120510080(TMPRSS6)

OTC:	121342389(TMPRSS6)

PRUF:

121361169(TMPRSS6)

GFR:	102031334(TMPRSS6)

FAB:	101809510(TMPRSS6)

OMA:	130248313(TMPRSS6)

PHI:	102106193(TMPRSS6)

PMAJ:

107204848(TMPRSS6)

CCAE:

111935367(TMPRSS6)

CCW:	104696291(TMPRSS6)

CBRC:

103618065(TMPRSS6)

ETL:	114055418(TMPRSS6)

ZAB:	102071477(TMPRSS6)

ACHL:

103811053(TMPRSS6)

SVG:	106858520(TMPRSS6)

MMEA:

130586753(TMPRSS6)

HRT:	120752059(TMPRSS6)

FPG:	101915089(TMPRSS6)

FCH:	102058575(TMPRSS6)

CLV:	102091291(TMPRSS6)

EGZ:	104134298(TMPRSS6)

NNI:	104021586(TMPRSS6)

PCRI:

104035329(TMPRSS6)

PLET:

104623812(TMPRSS6)

EHS:	104515453(TMPRSS6)

PCAO:

104047661(TMPRSS6)

ACUN:

113491336(TMPRSS6)

TALA:

104362149(TMPRSS6)

PADL:

103924178(TMPRSS6)

AFOR:

103907723(TMPRSS6)

ACHC:

115352723(TMPRSS6)

HALD:

104316500(TMPRSS6)

HLE:	104842805(TMPRSS6)

AGEN:

126047794

GCL:

127016947

CCRI:

104169332(TMPRSS6)

CSTI:

104557105(TMPRSS6)

CMAC:

104487051(TMPRSS6)

MUI:	104545015(TMPRSS6)

BREG:

104636091(TMPRSS6)

FGA:	104074076(TMPRSS6)

GSTE:

104260061(TMPRSS6)

LDI:	104343968(TMPRSS6)

MNB:	103771297(TMPRSS6)

OHA:	104332365(TMPRSS6)

NNT:	104409152(TMPRSS6)

SHAB:

115604927(TMPRSS6)

DPUB:

104302046(TMPRSS6)

PGUU:

104465981(TMPRSS6)

ACAR:

104520855(TMPRSS6)

CPEA:

104395981(TMPRSS6)

AVIT:

104273384(TMPRSS6)

CVF:	104283650(TMPRSS6)

RTD:	128904189(TMPRSS6)

CUCA:

104065860(TMPRSS6)

TEO:	104376811(TMPRSS6)

BRHI:

104501042(TMPRSS6)

AAM:	106488413(TMPRSS6)

AROW:

112969310(TMPRSS6)

NPD:	112947749(TMPRSS6)

TGT:	104576728(TMPRSS6)

DNE:	112993905(TMPRSS6)

SCAM:

104150236(TMPRSS6)

ASN:	102377108(TMPRSS6)

AMJ:	102571953(TMPRSS6)

CPOO:

109316633(TMPRSS6)

GGN:	109296053(TMPRSS6)

PSS:	102444568(TMPRSS6)

CMY:	102943942(TMPRSS6)

CCAY:

125628232(TMPRSS6)

DCC:	119857174(TMPRSS6)

CPIC:

101951084(TMPRSS6)

TST:	117880789(TMPRSS6)

CABI:

116824118(TMPRSS6)

MRV:	120393405(TMPRSS6)

ACS:	100560846(tmprss6)

ASAO:

132775910(TMPRSS6)

PVT:	110075956(TMPRSS6)

SUND:

121931316(TMPRSS6)

PBI:	103060257(TMPRSS6)

PMUR:

107302576(TMPRSS6)

CTIG:

120312415(TMPRSS6)

PGUT:

117655804(TMPRSS6)

APRI:

131201630(TMPRSS6)

PTEX:

113433297(TMPRSS6)

NSS:	113432758(TMPRSS6)

VKO:	123028868(TMPRSS6)

PMUA:

114604982(TMPRSS6)

PRAF:

128422868(TMPRSS6)

ZVI:	118090826(TMPRSS6)

HCG:	128327548(TMPRSS6)

GJA:	107123255(TMPRSS6)

STOW:

125434914(TMPRSS6)

EMC:	129335397(TMPRSS6)

XLA:	108714560(tmprss6.L) 108715798(tmprss6.S)

XTR:	100489045(tmprss6)

NPR:	108783676(TMPRSS6)

RTEM:

120945329(TMPRSS6)

BBUF:

120978930(TMPRSS6)

BGAR:

122943610(TMPRSS6)

MUO:	115474634(TMPRSS6)

GSH:	117354877(TMPRSS6)

DRE:

100005420

SRX:	107705912(tmprss6) 107724765

SANH:

107673319 107676729(tmprss6)

SGH:	107554700(tmprss6)

CCAR:

109075509(tmprss6)

CAUA:

113059410 113095154(tmprss6)

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:	108272331 108278024

IFU:

128616170

PHYP:

113525556 113538293(tmprss6)

SMEO:

124388540

TFD:

113634482

TVC:

132844911

AMEX:

103036174(tmprss6) 111197381

CMAO:

118807885

EEE:	113580369(tmprss6)

TRU:	101063402(tmprss6)

TFS:

130526777

TNG:	GSTEN00034830G001

LCO:	104925441(tmprss6)

NCC:	104943494(tmprss6)

TBEN:

117496537

CGOB:

115005485(tmprss6)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116700872(tmprss6)

PFLV:

114547077(tmprss6)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101464220(tmprss6)

ONL:	100708847(tmprss6) 102082417

OAU:

116329129

OLA:	101162577(tmprss6)

OML:

112137093

CSAI:

133442526

XMA:	102235853(tmprss6) 111608141

XCO:	114139631 114143838(tmprss6)

XHE:	116719314(tmprss6)

PRET:

103477882 103478195(tmprss6)

PFOR:

103156072(tmprss6)

PLAI:

106936824(tmprss6)

PMEI:

106919789(tmprss6)

GAF:

122830323

PPRL:

129367324

CVG:	107083554 107084268(tmprss6)

CTUL:

119798244

GMU:

124868419

NFU:	107375159(tmprss6)

KMR:	108236269 108240329

ALIM:

106522492(tmprss6) 106530058

NWH:

119423150

AOCE:

111579868(tmprss6)

MCEP:

125003838

CSEM:

103383424(tmprss6)

POV:	109633082 109639254(tmprss6)

SSEN:

HHIP:

HSP:

SMAU:

LCF:	108889055 108899424

SDU:	111216629(tmprss6)

SLAL:

111671818(tmprss6)

XGL:

120800341

BPEC:

110157758

MALB:

109975045(tmprss6)

BSPL:

114860163

SJO:

128370380

SASA:

106592627

STRU:

115177913 115181701(tmprss6)

OTW:

121845347

OMY:	110487257 110494898

OGO:	124002815 124024590

OKI:	109878994 109879002

OKE:	127927222 127931938

SALP:

111964677

SNH:	120032926 120032927

CCLU:

121555847

ELS:	105009014(tmprss6)

SFM:	108930688(tmprss6)

PKI:	111845213(tmprss6)

AANG:

118217831

LOC:	102688318(tmprss6)

PSPA:

121309366

PSEX:

120536975

LCM:	102366556(TMPRSS6) 106705517

CMK:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

SCLV:

SOC:

AEC:

ACEP:

VEM:

NVI:	100120125(SP67)

PTRU:

CSCU:

PTEP:

TSP:

LGI:	LOTGIDRAFT_104147

PCAN:

112574799

MYI:

110465206

OVI:	T265_09328

NVE:

5511325

EPA:	110233036 110239604 110242890 110253551

ATEN:

116290560 116302412

AMIL:

114962996

PDAM:

113664816 113665346 113667498

SPIS:

111320578 111335944 111335949

DGT:

114516205

» show all

Reference

PMID:12149247

Authors

Velasco G, Cal S, Quesada V, Sanchez LM, Lopez-Otin C

Title

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins.

Journal

J Biol Chem 277:37637-46 (2002)
DOI:10.1074/jbc.M203007200

Sequence

[hsa:164656]

Reference

PMID:18408718

Authors

Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, Mayo MM, Samuel SM, Strouse JJ, Markianos K, Andrews NC, Fleming MD

Title

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA).

Journal

Nat Genet 40:569-71 (2008)
DOI:10.1038/ng.130

LinkDB

DBGET integrated database retrieval system