KEGG ORTHOLOGY: K12337

ORTHOLOGY: K12337

Entry

K12337                      KO

Symbol

MRVI1, IRAG

Name

inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate

Pathway

map04022

cGMP-PKG signaling pathway

map04270

Vascular smooth muscle contraction

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K12337  MRVI1, IRAG; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12337  MRVI1, IRAG; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate

Genes

HSA:	10335(IRAG1)

PTR:	451025(MRVI1)

PPS:	100987349(IRAG1)

GGO:	101128034(MRVI1)

PON:	100444150(MRVI1)

NLE:	100592244(MRVI1)

HMH:	116476515(IRAG1)

MCC:	702830(MRVI1)

MCF:	102133824(IRAG1)

MTHB:

126935645

MNI:	105488774(MRVI1)

CSAB:

103240251(MRVI1)

CATY:

105595695(MRVI1)

PANU:

101005326(MRVI1)

TGE:	112605609(MRVI1)

MLEU:

105531905(MRVI1)

RRO:	104679290(MRVI1)

RBB:	108512623(MRVI1)

TFN:	117080999(IRAG1)

PTEH:

111524710(MRVI1)

CANG:

105515751(MRVI1)

CJC:	100389827(IRAG1)

SBQ:	101051847(MRVI1)

CIMI:

108283752(IRAG1)

CSYR:

103271791(MRVI1)

MMUR:

105866491(MRVI1)

LCAT:

123642437(IRAG1)

PCOQ:

105818294(MRVI1)

OGA:	100952022(MRVI1)

MMU:	17540(Irag1)

MCAL:

110297929(Mrvi1)

MPAH:

110328767(Mrvi1)

RNO:	308899(Irag1)

MCOC:

116102798(Mrvi1)

ANU:	117721895(Irag1)

MUN:	110540932(Irag1)

CGE:	100757809(Irag1)

MAUA:

101839738(Irag1)

PROB:

127228199(Irag1)

PLEU:

114697583(Irag1)

MORG:

121457899(Irag1)

MFOT:

126514463

AAMP:

119815414(Irag1)

HGL:	101708783(Mrvi1)

CPOC:

100734048(Mrvi1)

CCAN:

109699576(Mrvi1)

DORD:

105995059(Mrvi1)

DSP:	122117858(Irag1)

PLOP:

125361162(Irag1)

NCAR:

124959841

MMMA:

107135647(Irag1)

OCU:	100008940(IRAG1)

OPI:	101527668(IRAG1)

TUP:	102499608(MRVI1)

CFA:	100855453(IRAG1)

CLUD:

112667626(IRAG1)

VVP:	112927067(MRVI1)

VLG:	121476062(IRAG1)

NPO:	129504982(IRAG1)

AML:	100466702(IRAG1)

UMR:	103656392(IRAG1)

UAH:	113245787(MRVI1)

UAR:	123786570(IRAG1)

ELK:

111159481

LLV:

125079574

MPUF:

101680860(MRVI1)

MNP:	132023080(IRAG1)

MLK:	131809228(IRAG1)

NVS:	122912725(IRAG1)

ORO:	101363761(MRVI1)

EJU:	114219407(MRVI1)

ZCA:	113914434(IRAG1)

MLX:	118004038(IRAG1)

NSU:	110576577(IRAG1)

LWW:	102741333(MRVI1)

FCA:	101088106(IRAG1)

PYU:	121018219(IRAG1)

PCOO:

112865095(MRVI1)

PBG:	122483562(IRAG1)

PVIV:

125176029(IRAG1)

LRUF:

124504905

PTG:	102959580(MRVI1)

PPAD:

109271130(MRVI1)

PUC:

125936129

AJU:	106971834(IRAG1)

HHV:	120237522(IRAG1)

BTA:	281918(IRAG1)

BOM:	102278336(MRVI1)

BIU:	109569717(MRVI1)

BBUB:

102406743(IRAG1)

BBIS:

104980572(MRVI1)

CHX:	102174494(MRVI1)

OAS:	101102086(IRAG1)

BTAX:

128060476(IRAG1)

ODA:	120876460(IRAG1)

CCAD:

122449969(IRAG1)

MBEZ:

129554512(IRAG1)

SSC:	100739522(MRVI1)

CFR:	102514873(MRVI1)

CBAI:

105076631(MRVI1)

CDK:	105086610(MRVI1)

VPC:	102529740(MRVI1)

BACU:

103019200(MRVI1)

BMUS:

118900104(IRAG1)

LVE:	103089431(MRVI1)

OOR:	101278262(IRAG1)

DLE:	111165289(MRVI1)

PCAD:

102990115(IRAG1)

PSIU:

116757756(MRVI1)

NASI:

112407680(MRVI1)

ECB:	100071324(MRVI1)

EPZ:	103542199(MRVI1)

EAI:	106833097(IRAG1)

MYB:	102245935(MRVI1)

MYD:	102772387(MRVI1)

MMYO:

118664826(IRAG1)

MLF:	102438199(MRVI1)

PKL:	118712830(IRAG1)

EFUS:

103294623(IRAG1)

MNA:	107532275(MRVI1)

DRO:	112303301(MRVI1)

SHON:

118989752(IRAG1)

AJM:	119040754(IRAG1)

PDIC:

114500651(IRAG1)

PHAS:

123810120(IRAG1)

MMF:	118628193(IRAG1)

PPAM:

129078121(IRAG1)

HAI:	109390128(MRVI1)

RFQ:	117030336(IRAG1)

PALE:

102878953(MRVI1)

PGIG:

120603198(IRAG1)

PVP:	105303545(MRVI1)

RAY:	107512136(MRVI1)

MJV:	108386037(IRAG1)

TOD:	119255468(IRAG1)

SARA:

101538015(MRVI1)

SETR:

126018899(IRAG1)

LAV:	100675762(MRVI1)

TMU:

101350255

ETF:	101648395(IRAG1)

DNM:	101446759(MRVI1)

MDO:	100029875(MRVI1)

GAS:	123252532(IRAG1)

SHR:	100918494(MRVI1)

AFZ:

127540183

PCW:	110218914(MRVI1)

OAA:	100078702(IRAG1)

GGA:	423037(MRVI1)

PCOC:

116242878(MRVI1)

MGP:	100542275(MRVI1)

CJO:	107314605(MRVI1)

TPAI:

128086751(IRAG1)

LMUT:

125694750(IRAG1)

NMEL:

110401592(MRVI1)

APLA:

101804622(IRAG1)

ACYG:

106040905(IRAG1)

CATA:

118249845(IRAG1)

AFUL:

116490249(MRVI1)

TGU:	100226740(IRAG1)

LSR:	110470090(MRVI1)

SCAN:

103826806(MRVI1)

PMOA:

120501269(IRAG1)

OTC:	121341580(IRAG1)

PRUF:

121352083(IRAG1)

GFR:	102045647(MRVI1)

FAB:	101816570(MRVI1)

OMA:	130254536(IRAG1)

PHI:	102099235(MRVI1)

PMAJ:

107206234(IRAG1)

CCAE:

111930523(MRVI1)

CCW:	104683089(IRAG1)

CBRC:

103625456(MRVI1)

ETL:	114057812(MRVI1)

ZAB:	102073083(MRVI1)

ACHL:

103807936(MRVI1)

SVG:	106853202(MRVI1)

MMEA:

130582982 130586792

HRT:	120753701(IRAG1)

FPG:	101919522(MRVI1)

FCH:	102047590(MRVI1)

CLV:	102085663(MRVI1)

EGZ:	104123176(MRVI1)

NNI:	104009451(MRVI1)

PCRI:

104026958(MRVI1)

PLET:

104625740(MRVI1)

EHS:	104503547(MRVI1)

PCAO:

104051333

ACUN:

113481261(MRVI1)

TALA:

104360936(IRAG1)

PADL:

103920743(MRVI1)

AFOR:

103906773(MRVI1)

ACHC:

115352056(IRAG1)

HALD:

104320141(MRVI1)

HLE:	104829504(MRVI1)

AGEN:

126047441

GCL:

127016910

CCRI:

104156205

CSTI:

104561425(MRVI1)

CMAC:

104473951(MRVI1)

MUI:	104547321(MRVI1)

BREG:

104633859

FGA:

104070972

GSTE:

104254494(MRVI1)

LDI:	104347337(MRVI1)

MNB:

103781576

OHA:	104326406(MRVI1)

NNT:	104405520(MRVI1)

SHAB:

115607136(IRAG1)

DPUB:

104304419(MRVI1)

PGUU:

104463546(MRVI1)

ACAR:

104530003(MRVI1)

CPEA:

104385748(MRVI1)

AVIT:

104268597

CVF:	104293168(MRVI1)

RTD:	128909035(IRAG1)

CUCA:

104068862(MRVI1)

TEO:	104375957(MRVI1)

BRHI:

104501446(MRVI1)

AAM:	106497113(MRVI1)

AROW:

112968462(MRVI1)

NPD:	112943524(MRVI1)

TGT:	104566380(MRVI1)

DNE:	112985702(MRVI1)

SCAM:

104147511(MRVI1)

ASN:	102376170(MRVI1)

AMJ:	102570186(MRVI1)

CPOO:

109321107(MRVI1)

GGN:	109299080(MRVI1)

PSS:	102449736(MRVI1)

CMY:	102943262(IRAG1)

CCAY:

125637761(IRAG1)

DCC:	119856649(IRAG1)

CPIC:

101940361(IRAG1)

TST:	117877174(IRAG1)

CABI:

116814613(IRAG1)

MRV:	120405394(IRAG1)

ACS:	100559176(mrvi1)

ASAO:

132770066(IRAG1)

PVT:	110077157(MRVI1)

SUND:

121927605(IRAG1)

PBI:	103053529(MRVI1)

PMUR:

107292141(MRVI1)

CTIG:

120306679(IRAG1)

TSR:	106537528(MRVI1)

PGUT:

117665333(IRAG1)

APRI:

131186395(IRAG1)

PTEX:

113439623(MRVI1)

NSS:	113410215(MRVI1)

VKO:	123021410(IRAG1)

PMUA:

114597883(MRVI1)

PRAF:

128415221(IRAG1)

ZVI:	118086973(IRAG1)

HCG:	128326098(IRAG1)

GJA:	107106771(MRVI1)

STOW:

125425738(IRAG1)

EMC:	129323453(IRAG1)

XLA:	108713734(irag1.L) 108715288(irag1.S)

XTR:	100488966(mrvi1)

NPR:	108785922(MRVI1)

RTEM:

120916997(IRAG1)

BBUF:

120980960(IRAG1)

BGAR:

122921094(IRAG1)

MUO:	115468882(MRVI1)

GSH:	117352272(IRAG1)

DRE:	100331961(mrvi1)

SRX:	107715451 107738352

SANH:

107670788 107681203

SGH:	107552971 107584697

CCAR:

109081561

CAUA:

113051858 113106469

CGIB:

127962041 128016503

PTET:

122348388(mrvi1)

LROH:

127168002(mrvi1)

OMC:	131544261(mrvi1)

PPRM:

120492677(mrvi1)

RKG:	130100321(mrvi1)

MAMB:

125265796(mrvi1)

CIDE:

127515454

MASI:

127412660 127422810

TROS:

130559787(mrvi1)

TDW:	130422849(mrvi1)

IPU:	108270884(mrvi1)

IFU:	128613341(mrvi1)

PHYP:

113536769(mrvi1)

TVC:	132837903(mrvi1)

AMEX:

103045672(mrvi1)

CMAO:

118819229(mrvi1)

EEE:	113578199(mrvi1)

CHAR:

105912343(mrvi1)

TRU:	101066361(mrvi1)

TFS:	130520652(mrvi1)

TNG:	GSTEN00017783G001

LCO:	104930102(mrvi1)

NCC:	104962970(mrvi1)

TBEN:

117471563(mrvi1)

CGOB:

115005343(mrvi1)

PGEO:

117467524(mrvi1)

GACU:

117533278(mrvi1)

EMAC:

134862861(mrvi1)

ELY:	117268210(mrvi1)

EFO:	125878732(mrvi1)

PLEP:

121942937(mrvi1)

SLUC:

116067712(mrvi1)

ECRA:

117946542(mrvi1)

ESP:	116691968(mrvi1)

PFLV:

114554263(mrvi1)

GAT:	120813088(mrvi1)

PPUG:

119229320(mrvi1)

AFB:	129105958(mrvi1)

CLUM:

117751502(mrvi1)

PSWI:

130192625(mrvi1)

MSAM:

119890572(mrvi1)

SCHU:

122878879(mrvi1)

CUD:	121509657(mrvi1)

ALAT:

119017750(mrvi1)

MZE:	101480449(mrvi1)

ONL:	100693951(mrvi1)

OAU:	116317245(mrvi1)

OLA:	101163648(mrvi1)

OML:	112161248(mrvi1)

CSAI:

133461968(mrvi1)

XMA:	102236021(mrvi1)

XCO:	114142541(mrvi1)

XHE:	116718117(mrvi1)

PRET:

103462468(mrvi1)

PFOR:

103139471(mrvi1)

PLAI:

106946802(mrvi1)

PMEI:

106923856(mrvi1)

GAF:	122819625(mrvi1)

PPRL:

129364156(mrvi1)

CVG:	107090193(mrvi1)

CTUL:

119791558(mrvi1)

GMU:	124866898(mrvi1)

NFU:	107381414(mrvi1)

KMR:	108251150(mrvi1)

ALIM:

106531132(mrvi1)

NWH:	119428011(mrvi1)

AOCE:

111576886(mrvi1)

MCEP:

125005284(mrvi1)

CSEM:

103398426(mrvi1)

POV:	109636763(mrvi1)

SSEN:

122772379(mrvi1)

HHIP:

117757922(mrvi1)

HSP:	118111210(mrvi1)

SMAU:

118302961(mrvi1)

LCF:	108874577(mrvi1)

SDU:	111236579(mrvi1)

SLAL:

111658367(mrvi1)

XGL:	120789979(mrvi1)

HCQ:	109525836(mrvi1)

SSCV:

125967057

SBIA:

133497670(mrvi1)

PEE:	133399379(mrvi1)

PTAO:

133466557(mrvi1)

BPEC:

110172997(mrvi1)

MALB:

109964938(mrvi1)

BSPL:

114852408(mrvi1)

SJO:	128363296(mrvi1)

SASA:

106562099 106587202

STRU:

115167298 115203049

OTW:	112249146 112263670

OMY:	110506477 110526367

OGO:	124028403 124033489 124035767

ONE:	115112532 115113632

OKE:	118393830(mrvi1)

SALP:

111974904(mrvi1)

SNH:	120025173 120046672

CCLU:

121555731(mrvi1)

ELS:	105016944(mrvi1)

SFM:	108934518 108942186

PKI:	111832971 111850538(mrvi1)

PSPA:

121295000 121330391

PSEX:

120535598(mrvi1)

LCM:	102349520(MRVI1)

CMK:	103189090(mrvi1)

CPLA:

122557738(mrvi1)

HOC:	132824463(mrvi1)

PMRN:

LRJ:

BFO:

BBEL:

CLEC:

NLU:

DFR:

SDM:

PVUL:

HRJ:

OBI:

OSN:

Reference

PMID:14729908

Authors

Fritsch RM, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhoringer A, Hofmann F, Allescher HD

Title

InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle.

Journal

J Biol Chem 279:12551-9 (2004)
DOI:10.1074/jbc.M313365200

Sequence

[hsa:10335]

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