KEGG   ORTHOLOGY: K15467
Entry
K15467                      KO                                     
Symbol
rif14
Name
27-O-demethylrifamycin SV methyltransferase [EC:2.1.1.315]
Pathway
map01051  Biosynthesis of ansamycins
map01052  Type I polyketide structures
map01110  Biosynthesis of secondary metabolites
Reaction
R06998  S-adenosyl-L-methionine:27-O-demethylrifamycin-SV 27-O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15467  rif14; 27-O-demethylrifamycin SV methyltransferase
   01051 Biosynthesis of ansamycins
    K15467  rif14; 27-O-demethylrifamycin SV methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15467  rif14; 27-O-demethylrifamycin SV methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.315  27-O-demethylrifamycin SV methyltransferase
     K15467  rif14; 27-O-demethylrifamycin SV methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K15467  rif14; 27-O-demethylrifamycin SV methyltransferase
Genes
ETB: N7L95_28790
SGRF: SGFS_005370 SGFS_005510
SOV: QZH56_34125
AMD: AMED_0650
AMN: RAM_03320
AMM: AMES_0648
AMZ: B737_0649
SAQ: Sare_1271
Reference
PMID:9512878
  Authors
August PR, Tang L, Yoon YJ, Ning S, Muller R, Yu TW, Taylor M, Hoffmann D, Kim CG, Zhang X, Hutchinson CR, Floss HG
  Title
Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.
  Journal
Chem Biol 5:69-79 (1998)
DOI:10.1016/S1074-5521(98)90141-7
  Sequence
[amn:RAM_03320]
Reference
PMID:12623077
  Authors
Xu J, Mahmud T, Floss HG
  Title
Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.
  Journal
Arch Biochem Biophys 411:277-88 (2003)
DOI:10.1016/S0003-9861(03)00004-3
LinkDB

DBGET integrated database retrieval system