KEGG ORTHOLOGY: K24041

ORTHOLOGY: K24041

Entry

K24041                      KO

Symbol

yxeI

Name

penicillin V amidase [EC:3.5.1.11]

Pathway

map00311

Penicillin and cephalosporin biosynthesis

map01110

Biosynthesis of secondary metabolites

Reaction

R02170

penicillin amidohydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K24041  yxeI; penicillin V amidase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K24041  yxeI; penicillin V amidase
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.11  penicillin amidase
     K24041  yxeI; penicillin V amidase
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C59
   K24041  yxeI; penicillin V amidase

Other DBs

COG:

COG3049

GO:

0008953

Genes

CYS:	NYP54_00340

SDO:	SD1155_05675

AFC:	AFAEC_0049

BSU:	BSU39540(yxeI)

BSR:

I33_4122

BSL:

A7A1_1988

BSH:	BSU6051_39540(yxeI)

BSY:	I653_19430

BSUT:

BSUB_04196(yxeI)

BSUL:

BSUA_04196(yxeI)

BSUS:

Q433_21830

BSO:	BSNT_10638(yxeI)

BSN:	BSn5_10795

BSQ:	B657_39540(yxeI)

BSX:

C663_3873

BSP:	U712_20000

BSS:	BSUW23_19725(yxeI)

BST:

GYO_4361

BIT:	BIS30_09645

BLI:	BL00216(yxeI)

BLD:	BLi04217(yxeI)

BLH:	BaLi_c42090(yxeI)

BAY:	RBAM_035950

BAQ:	BACAU_3617(yxeI)

BYA:	BANAU_3777(yxeI)

BAMP:

B938_18415

BQY:	MUS_4270(yxeI)

BAML:

BAM5036_3515(yxeI)

BAMA:

RBAU_3724(yxeI)

BAMN:

BASU_3503(yxeI)

BAMB:

BAPNAU_3791(yxeI)

BAMT:

AJ82_20290

BAMY:

V529_38680(yxeI)

BMP:	NG74_03770

BAO:	BAMF_3707(yxeI)

BAZ:	BAMTA208_19605(yxeI)

BQL:	LL3_04025(yxeI)

BXH:	BAXH7_04020(yxeI)

BAMI:

BAMC:

BAMF:

BSIA:

BAE:	BATR1942_17775

BVM:	B9C48_18375

BSON:

S101395_04928

BHT:	DIC78_11150

BMOJ:

HC660_38730(yxeI)

BIQ:	AN935_20115

BSTR:

QI003_23330(yxeI)

BAN:

BA_3898

BAR:

GBAA_3898

BAT:

BAS3611

BAH:	BAMEG_0733

BAI:

BAA_3923

BAX:	H9401_3712

BANT:

BANR:

BANS:

BANH:

BANV:

DJ46_2601(cbh)

BCE:

BC1015

BCA:

BCE_3801

BCR:	BCAH187_A3807

BCB:	BCB4264_A1046

BCU:	BCAH820_3779

BCG:	BCG9842_B4255

BCQ:	BCQ_3553(cbaH)

BCX:

BCA_3864

BAL:	BACI_c37120(cbaH)

BNC:

BCF:

BCER:

BCEF:

BTK:	BT9727_3508(cbaH)

BTL:

BALH_3395

BTB:	BMB171_C0890

BTT:

HD73_1165

BTHR:

YBT1520_05825

BTHI:

BTK_05880

BTC:	CT43_CH0954

BTF:	YBT020_18465

BTM:

MC28_G097

BTG:	BTB_c10700

BTI:

BTG_15890

BTN:	BTF1_02815

BTHT:

H175_ch0967

BTHU:

YBT1518_06110

BTW:	BF38_4937(cbh)

BTHY:

AQ980_25070

BWE:	BcerKBAB4_3538

BWW:	bwei_1191(cbh)

BMYO:

BG05_2256

BBY:	CY96_04355 CY96_29070

BWD:	CT694_20300

BTRO:

BMOB:

BPAC:

BPAN:

BALU:

BGY:

BRY:	M0696_20155

BJS:

BACP:

BACB:

BACY:

BACL:

BALM:

BACS:

BGI:	BGM20_14040

AXL:

AXY_05200

LSP:

Bsph_3261

LGY:	T479_10275

LYB:	C3943_18900

LPAK:

GDS87_10250

LYC:	FH508_0017090

VNT:	OLD84_02120

BLEN:

NCTC4824_00975(yxeI)

SA0264

SAV:

SAV0275

SAW:

SAHV_0273

SAH:	SaurJH1_0266

SAJ:	SaurJH9_0259

SAM:

SAS:

SAR:

SAC:

SAX:	USA300HOU_0288

SAA:	SAUSA300_0269

SAO:	SAOUHSC_00247

SAE:

NWMN_0209

SAD:

SAAV_0243

SUU:	M013TW_0256

SUV:	SAVC_01120

SUE:

SAOV_0216

SUJ:	SAA6159_00253

SUK:	SAA6008_00249

SUC:

ECTR2_236

SUT:	SAT0131_00270

SUQ:	HMPREF0772_10225

SUZ:

MS7_0266

SUD:	ST398NM01_0290

SUX:	SAEMRSA15_02340

SUW:	SATW20_02770

SUG:

SAPIG0290

SUF:	SARLGA251_02390

SAUA:

SAUE:

SAUN:

SAUS:

SAUU:

SAUG:

SAUZ:

SAUT:

SAUJ:

SAUK:

SAUQ:

SAUV:

SAUW:

SAUX:

SAUY:

SAUF:

SAB:

SUY:	SA2981_0275

SAUB:

SAUM:

SAUC:

SAUR:

SAUI:

SAUD:

SAMS:

SUH:	SAMSHR1132_02410

SER:

SEP:

SEPP:

SEPS:

SHA:

SHH:	ShL2_00215

SSP:

SSP0146

SCA:

SCA_0210

SLG:	SLGD_02308

SLN:	SLUG_22250

SWA:	A284_10405

SPAS:

STP1_1666

SXY:	BE24_11305

SXL:	SXYLSMQ121_0157

SXO:	SXYL_00151

SCAP:

AYP1020_2330

SEQO:

SE1039_24220

SSIF:

AL483_08795 AL483_08800

SCV:	A4G25_06625

SPET:

CEP67_07275

SCOH:

BZ166_05320

SNL:	BJD96_01090

SKL:	C7J89_12555

SCAR:

DWB96_11630

SARL:

SAP2_21850

SPIC:

SAMEA4384060_2314(yxeI)

SSH:	NCTC13712_00220(yxeI)

SSIM:

SAMEA4384339_0239(yxeI)

SDB:	CNQ82_12925

SLLO:

SAUL:

SSAC:

SPSD:

STAS:

SURY:

SEDA:

SCAQ:

SDEV:

SROT:

STAP:

LMO:

LMN:	LM5578_0479

LMY:	LM5923_0478

LMT:	LMRG_00138

LMOC:

LMOSLCC5850_0448

LMOD:

LMON_0453

LMOW:

AX10_10785

LMR:	LMR479A_0455

LMOM:

IJ09_08100

LMG:	LMKG_01463

LMS:

LMLG_1979

LMW:	LMOSLCC2755_0451

LMX:	LMOSLCC2372_0450

LMZ:	LMOSLCC2482_0450

LMON:

LMOSLCC2376_0445

LMOY:

LMOSLCC2479_0449

LWI:	UE46_12875 UE46_12880 UE46_12930

LNW:	OTR81_09040 OTR81_09045

BTHS:

CNY62_12745

PALR:

HGI30_20340

KUR:

ASO14_140

KZO:	NCTC404_01294(yxeI)

LLA:	L149164(pacA) L86424(pacB)

LLK:	LLKF_1160(pacA) LLKF_2027(pacB)

LLT:	CVCAS_1106(pacA) CVCAS_1771(pacB)

LLS:	lilo_1036(pacA) lilo_1838(pacB)

LLD:	P620_06155 P620_10375

LLX:	NCDO2118_1135(pacA) NCDO2118_1956(pacB)

LLJ:	LG36_1247(pacA) LG36_1791(pacB)

LLM:	llmg_1422(pacA)

LLR:

llh_6275

LLN:	LLNZ_07335

LLW:

kw2_1081

LGR:

LCGT_0048

LGV:

LCGL_0048

LPK:	LACPI_0841(cbh)

LACT:

D7I46_04140

LACK:

FLP15_09210

LTI:	JW886_03435 JW886_05565

LCAR:

BHS00_06760

LPAA:

BHS01_07355

LPET:

lgb_00043(yxeI)

LFO:	LMK00_00225

LAPI:

DKL56_02205

LPAI:

GYM71_03180

LXO:	KIM322_04350(pacB)

LPL:	lp_0067(pva1) lp_2572(pva3) lp_3362(pva2)

LPJ:	JDM1_0076(bsh2) JDM1_2068(bsh4) JDM1_2695(bsh3)

LPT:	zj316_0023(pva2) zj316_0281(pva1) zj316_2493(pva3)

LPS:	LPST_C0055(bsh2) LPST_C2118(bsh4) LPST_C2764(bsh3)

LPR:	LBP_cg0055 LBP_cg2117 LBP_cg2742

LPZ:	Lp16_0067 Lp16_2042 Lp16_2646

LPB:	SH83_00290 SH83_10910 SH83_13975

LPX:	ASU28_10940 ASU28_13400

LPG:	BB562_00295 BB562_04760 BB562_15350

LARG:

LPA65_00285 LPA65_11220 LPA65_14460

LFE:

LAF_0941

LFR:

LC40_0616

LFF:

LBFF_1007

LMU:	LBLM1_05385

LOR:	AYI71_14245

LVA:	LV515_01085

LPON:

LGAS:

LPAS:

LPOR:

LNG:	BSQ50_05990

LHW:	BSQ49_09490

LBH:	Lbuc_0220 Lbuc_1960

LBN:	LBUCD034_0261(bsh) LBUCD034_2047

LPAR:

FAM21731_00765 FAM21731_01456

LCU:	PL11_005440

LKF:	DNL43_07440 DNL43_07545

LHIL:

G8J22_02252(yxeI_2) G8J22_02490(yxeI_3)

LBR:	LVIS_1962 LVIS_2132

LBK:	LVISKB_1943 LVISKB_2189

LKO:	ABN16_06680 ABN16_08360

LZY:	LZ3411_1986 LZ3411_2194

LSUA:

H3M12_00795 H3M12_01745 H3M12_04085

LNA:	RIN67_01550 RIN67_02820

LBT:	AYR52_08030

LHO:	LOOC260_101390

LNN:	F0161_02275

LPD:	AYR62_15280

LMAE:

FGL90_05405

PDM:	ADU72_1015

PIO:	PI20285_10305

LROS:

LROSL1_0507 LROSL1_2459

LGN:	ABM34_07110

LHI:	JP39_10140

LCT:	BI355_1918

LALW:

BTM29_04535

LALI:

LA20249_09720

LFM:	LF20184_01775

LZH:	D1B17_10985

LFT:	FG051_01390

CPAB:

G6534_00315

LSA:

LCA_0210

BOG:	MOO47_03720

BFP:	MOO45_06225

OOE:

OEOE_1038

OEN:	DSM07_00650

OSI:	DLJ48_04590

WKO:

WKK_03790

ESS:	ATZ33_12135

ERAF:

J9537_15750

EIE:	ENLAB_11290

VTE:	BHY08_05135

VPI:	BW732_00380 BW732_03940

VAH:	G7081_00485 G7081_03595 G7081_03635

VCP:	H9L18_10830

VHY:	G7082_09920

VFV:	K5K99_06825

VLU:	M2919_07085

VLC:	G314FT_15200(yxeI)

VIE:	OL234_05575

FHM:	R0V13_07820

CML:	BN424_1618(bsh3) BN424_344(yxeI) BN424_349(yxeI) BN424_3599(yxeI)

CDJ:	BFC22_01065

CVD:	LHA31_07770

CBK:

CBT:

CBE:

CBZ:

CBEI:

CLS:	CXIVA_19040

CSR:	Cspa_c31260

CSB:	CLSA_c09530

CSQ:

CSCA_3421

CCK:	Ccar_24095

CDRK:

B9W14_02555

CIA:	BEN51_12230

CDY:	F3K33_18815

CGEL:

CINT:

PROQ:

ESR:

ESU:

RUM:	CK1_27720 CK1_38360

RUS:	RBI_I00324(cbaH)

RUJ:	E5Z56_01385

FPRA:

CG447_06965

FDU:	GXM22_01965

CARL:

PXC00_07515

SMAN:

C12CBH8_21870(pacB)

PFAA:

MM59RIKEN_05330(yxeI)

VCOP:

MM50RIKEN_08370(cbh3)

CAPR:

EQM14_07275

CFEM:

HCR03_03790

EVN:	NQ558_11135(bsh)

AWO:	Awo_c31760(yxeI1) Awo_c33710(yxeI2)

AWI:	CHL1_003273

BPEN:

NQ488_14435(bsh)

BPRS:

CK3_08870

BCRO:

NQ527_02850(bsh)

RHO:	RHOM_14915 RHOM_15180

RIX:	RO1_19550 RO1_33910

RIM:	ROI_05990 ROI_07010

RRK:	H8S51_005400(bsh)

COO:

CCU_14250

CCT:

CC1_30750

CCOM:

I6K69_02210(bsh) I6K69_06355(bsh)

CEV:	LK421_09525(bsh)

ROB:	CK5_10630 CK5_18830

BLAB:

EYS05_02485

BMAS:

LK422_03435(bsh)

BHV:	BLHYD_18040(yxeI) BLHYD_31900

LACY:

A4V08_10945

CSH:	Closa_0510

BPRL:

CL2_15710

ARF:	AR1Y2_2216

ACAC:

EYQ97_06905

EHL:	EHLA_1602 EHLA_2245

ACEL:

acsn021_35240

EEL:	EUBELI_01636 EUBELI_20651

RGN:	RGna_01955

CBOL:

CGC65_09410 CGC65_25200

CASP:

NQ535_25950

DLO:	K5I24_10170(bsh) K5I24_15435(bsh)

WCP:	H9Q76_09090

SSUN:

H9Q77_16330

QDO:	H9Q78_09555

ERE:	EUBREC_2835

ERT:

EUR_24390

ERA:

ERE_09840

KIB:	RBB56_11255

CBIL:

EUBC25_22920(pacB)

CPRO:

CPRO_20980

ETM:	CE91St48_32950

KPAR:

JL105_06315

TIS:	P3962_08775

TIZ:	RBU61_04890

ERH:

ERH_0215

ERS:	K210_08260

ERD:	G7062_02020

EIO:	H9L01_09050 H9L01_09200

LCG:	L3BBH23_04060

FIT:	Fi14EGH31_09040

TSF:	NQ543_01510

APAL:

BN85412790(pacB)

RUFI:

K0V07_15160

MARO:

MarbSA_06010

» show all

Reference

PMID:16511127

Authors

Rathinaswamy P, Pundle AV, Prabhune AA, Sivaraman H, Brannigan JA, Dodson GG, Suresh CG

Title

Cloning, purification, crystallization and preliminary structural studies of penicillin V acylase from Bacillus subtilis.

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun 61:680-3 (2005)
DOI:10.1107/S1744309105017987

Sequence

[bsu:BSU39540]

Reference

PMID:9009066

Authors

Pundle A, SivaRaman H

Title

Bacillus sphaericus penicillin V acylase: purification, substrate specificity, and active-site characterization.

Journal

Curr Microbiol 34:144-8 (1997)
DOI:10.1007/s002849900159

LinkDB

DBGET integrated database retrieval system