KEGG   ORTHOLOGY: K24866
Entry
K24866                      KO                                     
Symbol
sirC
Name
precorrin-2 dehydrogenase [EC:1.3.1.76]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Reaction
R03947  S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K24866  sirC; precorrin-2 dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.76  precorrin-2 dehydrogenase
     K24866  sirC; precorrin-2 dehydrogenase
Other DBs
COG: COG1648
GO: 0043115
Genes
XCC: XCC2003(cysG)
XCB: XC_2181
XCA: xcc-b100_2303
XCP: XCR_2283
XCV: XCV2089
XAX: XACM_2067
XAC: XAC2159(cysG)
XCI: XCAW_01542
XCT: J151_02318
XCJ: J158_02307
XOM: XOO2947(XOO2947)
XOO: XOO3102(cysG)
XOP: PXO_01486
XOR: XOC_2454
XPH: XppCFBP6546_02685(XppCFBP6546P_02685)
XHD: LMG31886_22860(cysG_3)
PSUW: WQ53_08775
VCH: VC_1363
VCS: MS6_1138
VCI: O3Y_06335
VVU: VV1_2702
VVY: VV1558
VPA: VP1619
VPB: VPBB_1478
VAG: N646_0644
VSP: VS_1404
VAN: VAA_01887
VSC: VSVS12_01653(cysG)
VTA: A0751
VAQ: FIV01_07055(cysG1)
VSR: Vspart_01650(cysG_2)
VPL: SA104470976_01110(cysG_2)
VSY: K08M4_15830(cysG_1)
VFI: VF_1531
PPR: PBPRB0870(COBA2)
SON: SO_3108
SDN: Sden_1407
SFR: Sfri_2695
SAZ: Sama_2187
SBL: Sbal_2781
SLO: Shew_2332
SSE: Ssed_2886
SPL: Spea_1476
SHL: Shal_1560
SWD: Swoo_1762
SWP: swp_1684
SVO: SVI_1580
SPSW: Sps_03603
SKH: STH12_01925(cysG_1)
FBL: Fbal_2772
MVS: MVIS_3945(cysG)
BTRM: SAMEA390648702155(cysG)
PLA: Plav_2776
RBS: RHODOSMS8_01379(cysG)
CCR: CC_0024
CAK: Caul_0048
CSE: Cseg_0047
PZU: PHZ_c0287(ysG)
TSV: DSM104635_03089(sirC)
RAP: RHOA_5511
ALI: AZOLI_0773(cysG)
TXI: TH3_03325
TMO: TMO_2335(cysG)
SUA: Saut_0826
SULC: CVO_00330
SULR: B649_07105
SMUL: SMUL_1568(sirC)
SHAL: SHALO_1532
SULJ: SJPD1_1544
ATP: ATR_0634
ACIB: ACBT_1723
ACRE: ACRYA_1447
ATHR: ATH_0442
APOC: APORC_0454
ALK: ALEK_0577
AMYT: AMYT_0451
AMAR: AMRN_0476
ACAA: ACAN_0497
AMOL: AMOL_0409
APAI: APAC_0354
HBV: ABIV_0418
HYO: NNO_0553
HCJ: HCR_19640(cysG)
SUN: SUN_0295
NIS: NIS_1777
GSU: GSU3282(cysG)
GSK: KN400_3222(cysG)
GME: Gmet_3231(cysG)
GEM: GM21_0405
GEB: GM18_3975
GUR: Gura_0362
GEO: Geob_1302(cysG)
TAMM: GEAMG1_2540(cysG)
GBM: Gbem_0405(cysG)
GBN: GEOBRER4_03990(cysG)
PCA: Pcar_3066(cysG-1)
PPD: Ppro_3379
DEU: DBW_3491
DVE: DESUT3_05690(cysG)
DES: DSOUD_3158(cysG)
DDS: Ddes_0961
DTR: RSDT_0392(cysG)
DFL: DFE_0908
DMA: DMR_16440
DGG: DGI_2562
DDE: Dde_2023
DAS: Daes_1537
DPI: BN4_10715
PPRF: DPRO_0399(cysG)
PNW: SYK_05830
LIP: LI0320(cysG)
LIR: LAW_00331(cysG)
DVU: DVU_1463
DVL: Dvul_1616
DVM: DvMF_0298
CLIH: KPS_000400
DBA: Dbac_1748
DRT: Dret_1463
DPS: DP3081
DSF: UWK_00429
DLM: DPPLL_24040(cysG)
DBK: DGMP_25140(cysG)
DDU: GF1_24360
DOL: Dole_3236
DAL: Dalk_3436
DAT: HRM2_10890(cysG)
DALK: DSCA_39140
DLI: dnl_03920
SAT: SYN_02276
SFU: Sfum_1588
DBR: Deba_0329
DMP: FAK_41560(cysG)
CTHI: THC_0497
MXA: MXAN_2339
SCL: sce0393
BSU: BSU15630(sirC)
BSR: I33_1750
BSL: A7A1_3522
BSH: BSU6051_15630(sirC)
BSUT: BSUB_01694(sirC)
BSUL: BSUA_01694(sirC)
BSUS: Q433_08970
BSO: BSNT_08074(ylnF)
BSQ: B657_15630(sirC)
BSX: C663_1607(sirC)
BSS: BSUW23_08045(sirC)
BST: GYO_1912
BLI: BL02289(sirA)
BLD: BLi01784(sirC)
BLH: BaLi_c18170(sirC)
BAQ: BACAU_1517(ylnF)
BYA: BANAU_1514(ylnF)
BAMP: B938_08030
BQY: MUS_1713(ylnF)
BAML: BAM5036_1482(sirC)
BAMA: RBAU_1522(sirC)
BAMN: BASU_1502(sirC)
BAMB: BAPNAU_2207(ylnF)
BAMT: AJ82_08850
BAMY: V529_15020(ylnF)
BMP: NG74_01609(sirC)
BAO: BAMF_1634(sirC)
BAZ: BAMTA208_09335(sirC)
BQL: LL3_01722(sirC)
BXH: BAXH7_01899(ylnF)
BAMI: KSO_011625
BAMC: U471_15850
BAMF: U722_08210
BSON: S101395_03169(met8)
BMOJ: HC660_16280(sirC)
BSTR: QI003_08415(sirC) QI003_11840(sirC)
BCA: BCE_1551
BCQ: BCQ_1501(cysG) BCQ_2117
BTG: BTB_c14700(sirC1) BTB_c21940(sirC2)
BWW: bwei_2890 bwei_3569(sirC)
BMYO: BG05_4463
BPU: BPUM_1462
BPUM: BW16_08175
BPUS: UP12_07610
BGY: BGLY_1778
BAER: BAE_15205
BCAB: EFK13_08640(sirC)
BRY: M0696_08495(sirC)
BJS: MY9_1709
BACW: QR42_07470
BACP: SB24_01975
BACB: OY17_10805
BACO: OXB_3545
BACY: QF06_06840
BACL: BS34A_17320(sirC)
BALM: BsLM_1661
BMQ: BMQ_4926(sirC)
BMD: BMD_4912(sirC)
BMEG: BG04_1914(sirC)
BEO: BEH_22015
BHA: BH1497
BKW: BkAM31D_06050(sirC)
BCL: ABC0617
BPF: BpOF4_14425(sirA)
OIH: OB1657
GKA: GK0404
GTN: GTNG_0379
GEA: GARCT_00444(sirC)
PCAL: BV455_01338(sirC)
PARG: PspKH34_34180(cysG)
AFL: Aflv_0310
AAMY: GFC30_822
LSP: Bsph_3435
HHD: HBHAL_2680(sirC)
HLI: HLI_01910
VPN: A21D_01519(sirC)
PASA: BAOM_4948
BLEN: NCTC4824_00849(sirC)
BAG: Bcoa_0995
BCOA: BF29_2738
SAU: SA2412
SAV: SAV2619
SAW: SAHV_2603
SAM: MW2539
SAS: SAS2505
SAR: SAR2697
SAC: SACOL2638
SAX: USA300HOU_2617(cysG)
SAE: NWMN_2517(cysG)
SAD: SAAV_2686
SUK: SAA6008_02677(cysG)
SUZ: MS7_2624
SUG: SAPIG2667
SAUA: SAAG_00439
SAUE: RSAU_002460(cysG)
SAUS: SA40_2374
SAUU: SA957_2458
SAUG: SA268_2555
SAUF: X998_2601
SAB: SAB2493c
SAUB: C248_2682
SAUC: CA347_2695
SAUR: SABB_02029
SAUI: AZ30_13700
SAUD: CH52_05915
SAMS: NI36_13145
SER: SERP2188
SEP: SE_2177
SEPP: SEB_02179
SEPS: DP17_1113
SHA: SH0417
SHH: ShL2_00324(cysG)
SSP: SSP2404
SCA: SCA_1898(sirA)
SDT: SPSE_0394
SDP: NCTC12225_00463(sirC_1)
SPAS: STP1_1134
SHU: SHYC_02445(sirC)
SCAP: AYP1020_1804(sirC)
SSCH: LH95_02210
SSCZ: RN70_02495
SAGQ: EP23_07695
SARL: SAP2_03020
SPIC: SAMEA4384060_0631(sirA)
SSH: NCTC13712_02573(sirC)
SSIM: SAMEA4384339_2425(sirC)
SSTE: SAMEA4384403_0185(sirC_1) SAMEA4384403_0220(sirC_2)
MCL: MCCL_1341
MCAK: MCCS_17510(sirC)
LMO: lmo1141
LMOE: BN418_1341
LMOB: BN419_1338
LMOD: LMON_1134
LMOW: AX10_14210
LMOM: IJ09_04630
LMP: MUO_05900
LMOX: AX24_03070
LMQ: LMM7_1147(cysG)
LMS: LMLG_2812
LMOK: CQ02_05870
LIN: lin1105
LWE: lwe1099
LSG: lse_1017
LIV: LIV_1071
LGZ: NCTC10812_00739(sirC)
PPY: PPE_03680
PPO: PPM_3900(M1_4295)
PPOL: X809_35525
PPOY: RE92_17770
PMW: B2K_30880
PLV: ERIC2_c28500(sirC)
PSAB: PSAB_18445
PRI: PRIO_5401
PSWU: SY83_13755
PALO: E6C60_1244
PKP: SK3146_06021(sirC)
ASOC: CB4_00859(sirC)
AAC: Aaci_2427
AAD: TC41_2713
BTS: Btus_0651
JEO: JMA_24770
KUR: ASO14_987
KZO: NCTC404_02669(cysG_2)
SSA: SSA_0483
SMEN: SAMEA4412692_0372(sirC)
LRE: Lreu_1704
LRF: LAR_1592
PCE: PECL_1417(sirA)
CAC: CA_C0096(hemW)
CAE: SMB_G0097(cysG)
CAY: CEA_G0097(hemW)
CPE: CPE1436
CPF: CPF_1689
CPR: CPR_1423
CTC: CTC_00726
CBO: CBO0919
CBA: CLB_0960
CBH: CLC_0974
CBY: CLM_1067
CBL: CLK_0357
CBK: CLL_A2908
CBB: CLD_3640
CBI: CLJ_B0970
CBN: CbC4_2013
CBT: CLH_2650
CBF: CLI_1006
CBM: CBF_0978
CBE: Cbei_1284
CBZ: Cbs_1284
CBEI: LF65_01416
CKL: CKL_2909(sirC)
CKR: CKR_2579
CLJ: CLJU_c31990(sirC)
CLS: CXIVA_15050(CysG)
CSR: Cspa_c14900(sirC)
CPAS: Clopa_4355
CPAT: CLPA_c35340(cysG)
CPAE: CPAST_c35340(cysG)
CBV: U729_146
CSQ: CSCA_5059
CACE: CACET_c00480(cysG)
CTYK: CTK_C09370(hemW)
CRW: CROST_002940(cysG_1)
CFB: CLFE_000200(cysG_2)
CAUN: CLAUR_027160(cysG_2)
CNN: CNEO_1769
HHW: NCTC503_00578(cysG_1)
CTH: Cthe_2526
HSC: HVS_02695(sirC)
RUM: CK1_12340
RUS: RBI_I00191(cysG)
SWO: Swol_0683
SLP: Slip_1429
SALQ: SYNTR_0456
DSY: DSY2227(cysG)
DHD: Dhaf_3356
SGY: Sgly_0516
PTH: PTH_0970(CysG)
DRM: Dred_2165
DAE: Dtox_1249
DAU: Daud_1349
AACX: DEACI_2415
HMO: HM1_1963
ELM: ELI_0770
SAY: TPY_1377
CTHM: CFE_1690
BPRS: CK3_28890
CCT: CC1_32780
ROB: CK5_24610
BPRO: PMF13cell1_04245(sirC)
BCOC: BLCOC_32730(sirC)
BHV: BLHYD_14490(sirC)
CSCI: HDCHBGLK_00100(sirC)
BPRL: CL2_13310
EHL: EHLA_0215
ACEL: acsn021_29360(cysG)
ERT: EUR_19590
ERA: ERE_21930
AMT: Amet_0059
CDF: CD630_34180(sirC)
PDC: CDIF630_03726(sirC)
PDF: CD630DERM_34180(sirC)
PHX: KGNDJEFE_00436(cysG)
TMY: TEMA_36730(sirC)
TEB: T8CH_0265(sirC)
THX: Thet_0364
TIT: Thit_0364
TKI: TKV_c03340(cysG)
CHY: CHY_0754
ADG: Adeg_1261
TPZ: Tph_c15350(cysG)
TTM: Tthe_1596
TSH: Tsac_1653
MTA: Moth_1251
MTHO: MOTHE_c12320(cysG)
MTHZ: MOTHA_c13180(cysG)
NCD: ACONDI_00756(sirC)
HPRF: HLPR_10640
CSC: Csac_1650
ATE: Athe_1196
CDIA: CaldiYA01_13110(hemW)
PHAR: NCTC13077_00899(sirC)
PIV: NCTC13079_00960(sirC)
CAD: Curi_c24680(sirC)
VPR: Vpar_1427
VRM: 44547418_01504(cysG_2)
VDN: NCTC11831_01533(cysG_2)
MED: MELS_1867
PUF: UFO1_0015
PFT: JBW_04489
MANA: MAMMFC1_00905(cysG)
STED: SPTER_41990(cysG_2)
PFAC: PFJ30894_00529(sirC)
LPIL: LIP_3357
ELE: Elen_2072
GPA: GPA_16730
RXY: Rxyl_1980
BALA: DSM104299_05748(cysG_1)
CWO: Cwoe_5870
SBAE: DSM104329_05672(cysG_1)
CAU: Caur_0688
HAU: Haur_1745
TTR: Tter_0580
DGE: Dgeo_2129
DGO: DGo_CA2388(cysG)
TTH: TT_C0311
TTJ: TTHA0670(TTHA0670)
TSC: TSC_c11770(cysG)
TAQ: TO73_0876
MRB: Mrub_0854
VAB: WPS_16040
TACI: TDSAC_0880
MTAR: DF168_00486(cysG)
GES: VT84_34705(sirC)
FTJ: FTUN_5013
ULI: ETAA1_36530(sirC)
IPA: Isop_3697
SACI: Sinac_0212
AGV: OJF2_47800(sirC)
KST: KSMBR1_3803(cysG)
BPIT: BPIT_21300
PCOR: KS4_17600(sirC)
MCAD: Pan265_21400(sirC)
ALUS: STSP2_01674(cysG)
LIL: LA_4217(cysG)
LIE: LIF_A3364(cysG)
LIC: LIC_13368(cysG)
LIS: LIL_13473
LBJ: LBJ_2838(cysG)
LBL: LBL_0233(cysG)
LBI: LEPBI_I1178(sirA)
LBF: LBF_1135(cysG)
LST: LSS_08234
LKB: LPTSP3_g11300(cysG)
ACA: ACP_3018
SUS: Acid_1039
ABAC: LuPra_02143(cysG_3)
FNU: FN0539
FPOL: ERS445057_01764(sirC)
LBA: Lebu_1979
TAI: Taci_0045
FSC: FSU_0300
APS: CFPG_283
DORI: FH5T_12710
ANF: AQPE_0020
MBAS: ALGA_0792
CPI: Cpin_6615
SMIZ: 4412673_02155(cysG_1)
SDJ: NCTC13534_03109(cysG_1)
STHA: NCTC11429_04457(cysG_2)
MGOT: MgSA37_02810(cysG)
CHU: CHU_2635(cysG)
SLI: Slin_0478
PSEZ: HME7025_02440(met8)
LBY: Lbys_1792
DFE: Dfer_4780
FAE: FAES_4453
FLM: MY04_1859
PPSV: PEPS_40300(cysG)
ATK: AUTU_47370(cysG)
GFO: GFO_0329
GFL: GRFL_2109
FJO: Fjoh_1506
FJG: BB050_01111(cysG)
FBR: FBFL15_2618(cysG)
ZPR: ZPR_3629
MARM: YQ22_07830
CBAL: M667_07045
CBAT: M666_07085
ZGA: ZOBELLIA_1640(sirC)
POM: MED152_06150(cysG)
WIN: WPG_0731
TJE: TJEJU_3522(sirC)
TMAR: MARIT_2611(sirC)
AALG: AREALGSMS7_02109(cysG)
KAN: IMCC3317_37370(cysG)
MARF: CJ739_2129
MESQ: C7H62_0589
MLT: VC82_2058
SPON: HME9304_02256(met8)
FBU: UJ101_00250(MET8)
BBL: BLBBGE_281(sirBC)
CTE: CT2239
CPC: Cpar_0038
CCH: Cag_1943
CLI: Clim_0708
PVI: Cvib_0052
PLT: Plut_0049
PPH: Ppha_2307
PAA: Paes_0042
PROC: Ptc2401_00041(sirC)
RMR: Rmar_1669
AAE: aq_1237(cysG)
HTH: HTH_0950(cysG)
TAL: Thal_1555
TTK: TST_1527(mET8)
TME: Tmel_0710
TAF: THA_1080
NDE: NIDE2764
NJA: NSJP_3598
LFC: LFE_0038
LFI: LFML04_0061(cysG)
SCHV: BRCON_2208
MJA: MJ_0140
MMP: MMP0089
MMD: GYY_00455
MMAD: MMJJ_10050(cysG)
MAE: Maeo_0053
MVO: Mvol_1442
MTH: MTH_1013
MMG: MTBMA_c13950(cysG2)
MTEE: MTTB_04110
METC: MTCT_0921
METE: tca_00974(sirC)
MST: Msp_1407
MRU: mru_1852(cysG)
MSI: Msm_0968
MEB: Abm4_1482(cysG)
MMIL: sm9_1930(cysG)
MEYE: TL18_09110
MOL: YLM1_1307
METH: MBMB1_0195
MFC: BRM9_2105(cysG)
MCUB: MCBB_0210
MFV: Mfer_0314
MKA: MK1495(cysG_1)
AFU: AF_1592
FPL: Ferp_0012
GAC: GACE_1260
GAH: GAH_01503
MBAR: MSBR2_1950
MBAK: MSBR3_1995
MAC: MA_0576(cysG)
MMA: MM_1740
MMAC: MSMAC_1495
METM: MSMTP_2887
MTHR: MSTHT_2090
MTHE: MSTHC_1194
MHOR: MSHOH_3651
MBU: Mbur_1230(cysGB)
MMET: MCMEM_1682
MMH: Mmah_1457
MPY: Mpsy_2491
MEHF: MmiHf6_16000(cysG)
MEES: MmiEs2_01150(cysG)
MCJ: MCON_1503
MHI: Mhar_0165
MHU: Mhun_2563
MLA: Mlab_0522
MBG: BN140_1910(cysG)
MEMA: MMAB1_2465(cysG)
MPI: Mpet_1530
MAQE: RJ40_00095
MBN: Mboo_1239
MPL: Mpal_1729
MPD: MCP_2929(cysG)
MEZ: Mtc_0325(cysG)
RCI: RCIX909
HAL: VNG_1775C
HSL: OE_3498R(sirC)
HHB: Hhub_3078(sirC)
HALH: HTSR_1834(cysG2)
HHSR: HSR6_1903(cysG)
SALI: L593_09715
HARA: AArcS_2706(cysG)
HMA: rrnAC1709(hemX)
HHI: HAH_2244(hemX)
NPH: NP_4500A(sirC)
NMO: Nmlp_3269(sirC)
HUT: Huta_1755
HTI: HTIA_1355
HASV: SVXHr_2802(sirC)
HABN: HBNXHr_2741(sirC)
HMU: Hmuk_1613
HALL: LC1Hm_0660(cysG2)
HWA: HQ_3335A(sirC)
HWC: Hqrw_3864(sirC)
HVO: HVO_2312(sirC)
HME: HFX_2322(cysG)
HLN: SVXHx_2300(sirC)
HLA: Hlac_2131
HDF: AArcSl_3196(cysG)
HTU: Htur_3247
NMG: Nmag_1220(sirC)
NAT: NJ7G_2498
MELU: MTLP_04290
TAC: Ta0652
TVO: TVG0976073(TVG0976073)
FAI: FAD_0614
MARC: AR505_1046
APE: APE_1491.1(sirC)
ACJ: ACAM_0937(sirC)
IHO: Igni_0483
IIS: EYM_03450
HBU: Hbut_0510
PABI: PABY_22660
PARE: PYJP_07320
STO: STK_02110
SOL: Ssol_1159
SSOA: SULA_1195
SSOL: SULB_1196
SSOF: SULC_1194
SCAS: SACC_00940
SAI: Saci_0776
SID: M164_1964
SII: LD85_2216
SIH: SiH_1901
SIR: SiRe_1829
SIC: SiL_1810
MSE: Msed_0213
MEMJ: MJ1HA_0298
MCN: Mcup_1859
AHO: Ahos_0624
ACIH: HS5_19760
CSTY: KN1_16760
STEP: IC006_1875
SAHS: HS7_17200
PAI: PAE0585
PIS: Pisl_0119
PCL: Pcal_1710
PAS: Pars_2248
PYR: P186_2099
POG: Pogu_2613
TNE: Tneu_1896
CMA: Cmaq_1731
TTN: TTX_1556
TUZ: TUZN_1982
VDI: Vdis_0749
VMO: VMUT_1599
ASC: ASAC_0114
NMR: Nmar_0511
NCT: NMSP_1163
NEV: NTE_01383
TAA: NMY3_01278(sirC)
NFN: NFRAN_2251(sirC)
NCV: NCAV_0217
NBV: T478_0463
NDV: NDEV_0470
CCAI: NAS2_0061
NCON: LC1Nh_1141
LOKI: Lokiarch_29950(cysG_1)
 » show all
Reference
  Authors
Raux E, Leech HK, Beck R, Schubert HL, Santander PJ, Roessner CA, Scott AI, Martens JH, Jahn D, Thermes C, Rambach A, Warren MJ
  Title
Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium.
  Journal
Biochem J 370:505-16 (2003)
DOI:10.1042/BJ20021443
  Sequence
[bmq:BMQ_4926]
Reference
  Authors
Schubert HL, Rose RS, Leech HK, Brindley AA, Hill CP, Rigby SE, Warren MJ
  Title
Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase.
  Journal
Biochem J 415:257-63 (2008)
DOI:10.1042/BJ20080785
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