KEGG ORTHOLOGY: K01317

ORTHOLOGY: K01317

Entry

K01317                      KO

Symbol

ACR

Name

acrosin [EC:3.4.21.10]

Disease

H01282

Spermatogenic failure

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01317  ACR; acrosin
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01317  ACR; acrosin
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.10  acrosin
     K01317  ACR; acrosin
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K01317  ACR; acrosin
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    K01317  ACR; acrosin

Genes

HSA:

49(ACR)

PTR:	458950(ACR)

PPS:	100979160(ACR)

GGO:	101144239(ACR)

PON:	100448292(ACR)

PPYG:

129023123(ACR)

NLE:	100586140(ACR)

HMH:	116458999(ACR)

SSYN:

129467815(ACR)

MCC:	716579(ACR)

MCF:	102115325(ACR)

MTHB:

126964017

MNI:	105489733(ACR)

CSAB:

103223579 103223651(ACR)

PANU:

101010633 116270711

TGE:	112633283(ACR)

MLEU:

105543589(ACR)

RRO:	104655563(ACR)

RBB:	108545017(ACR)

TFN:	117096242(ACR)

PTEH:

111549166(ACR)

CANG:

105512002(ACR)

CJC:	100406660(ACR)

SBQ:	101047167(ACR)

CIMI:

108286851(ACR)

ANAN:

105706695(ACR)

CSYR:

103271503(ACR)

MMUR:

105884990(ACR)

LCAT:

123640348(ACR)

PCOQ:

105813926(ACR)

OGA:	100963151(ACR)

MMU:	11434(Acr)

MCAL:

110310440(Acr)

MPAH:

110334980(Acr)

RNO:	24163(Acr)

MCOC:

116078085(Acr)

ANU:	117718981(Acr)

ASYL:

127667705(Acr)

MUN:	110566471(Acr)

CGE:	100754856(Acr)

MAUA:

101839533(Acr)

PROB:

127225965(Acr)

PLEU:

114693039(Acr)

MORG:

121461410(Acr)

AAMP:

119823273(Acr)

NGI:	103735496(Acr)

HGL:	101712354(Acr)

CPOC:

100717414(Acr)

CCAN:

109693070(Acr)

DORD:

105992722(Acr)

DMER:

138811929(Acr)

NCAR:

124982996

MMMA:

107160221(Acr)

ITI:	101961747(Acr)

OCU:	100009184(ACR)

OPI:	101522965(ACR)

TUP:	102477933(ACR)

GVR:	103591321(ACR)

CFA:	606765(ACR)

CLUD:

112665305(ACR)

VVP:	112935879(ACR)

VLG:	121492162(ACR)

NPO:	129512087(ACR)

AML:	100482745(ACR)

UMR:	103674103(ACR)

UAH:	113241583(ACR)

UAR:	123803812(ACR)

ELK:

111157685

MPUF:

101682369(ACR)

MNP:	132020422(ACR)

MLK:	131839677(ACR)

NVS:	122891694(ACR)

ORO:	101363888 101379789(ACR)

EJU:	114203158 114203159 114203316 114218308(ACR)

ZCA:	113909159 113909160 113922803 113933199 113933897 118355967

MLX:	117997712(ACR)

NSU:	110578315(ACR)

LWW:	102727815(ACR)

FCA:	101083949(ACR)

PYU:	121040095(ACR)

PCOO:

112863376(ACR)

PBG:	122473012(ACR)

PVIV:

125170322(ACR)

LRUF:

124502535

LGF:	123590898(ACR)

AJU:

106987633

PTG:	102954045(ACR)

PPAD:

109265792(ACR)

PUC:

125919756

PLEZ:

122225308(ACR)

HHV:	120233554(ACR)

BTA:	280711(ACR)

BOM:	102270129(ACR)

BBUB:

102391015(ACR)

BBIS:

104980012(ACR)

CHX:	102191416(ACR)

OAS:	443195(ACR)

BTAX:

128049003(ACR)

CSUM:

138079329(ACR)

ODA:	120857786(ACR)

CCAD:

122423039(ACR)

MREE:

136160680(ACR)

OVR:	110125051(ACR)

MBEZ:

129537237(ACR)

SSC:	397098(ACR)

CFR:	102504353(ACR)

CBAI:

105070825(ACR)

CDK:	105106149(ACR)

VPC:	102543078(ACR)

BACU:

103017313(ACR)

BMUS:

118902739(ACR)

LVE:	103072664(ACR)

OOR:	101282422(ACR)

LALB:

132529224(ACR)

GMF:	115852559(ACR)

DDP:	132434361(ACR)

DLE:	111186384(ACR)

PCAD:

102982720(ACR)

PSIU:

116760485(ACR)

PPHC:

136130748(ACR)

NASI:

112394593(ACR)

ECB:	100057028(ACR)

EPZ:	103543987(ACR)

EAI:	106846026(ACR)

MYB:	102256900(ACR)

MYD:	102774021(ACR)

MMYO:

118657372(ACR)

MLF:	102426257(ACR)

MDT:	132225977(ACR)

MYUM:

139006552(ACR)

PKL:	118714759(ACR)

EFUS:

103298716(ACR)

MNA:	107536030(ACR)

DRO:	112321661(ACR)

SHON:

118989694(ACR) 119003110

AJM:	119060332(ACR)

PDIC:

114496816 114513967(ACR)

PHAS:

123816028(ACR) 123831647

MMF:	118641119(ACR)

PPAM:

129068320(ACR)

HAI:	109396613(ACR)

RFQ:	117028267(ACR)

PALE:

102886339(ACR)

PGIG:

120602806(ACR)

PVP:	105308288(ACR)

RAY:	107500248(ACR)

TOD:	119248216(ACR)

SARA:

101548761(ACR)

SFUM:

130016409(ACR)

SETR:

126006164(ACR)

LAV:	100674496(ACR)

TMU:

101350147

ETF:	101649792(ACR)

DNM:	101443016(ACR)

MDO:

103093639

GAS:	123250441(ACR)

SHR:	100916052 100932714(ACR)

AFZ:	127538776 127564743 127564929

PCW:	110201632 110202102 110205953 110213369

TVP:	118849515 118851405 118851917

PBRV:

138172437 138172984 138172997

GGA:	426864(ACR) 769176(ACRL)

PCOC:

116238651 116238654

MGP:	100539639 692129(ACR)

CJO:	107306626 107318185 107319775(ACR)

TPAI:

128091957 128091964

LMUT:

125684144 125684147

NMEL:

110392172(ACR) 110392173

APLA:

101793578 101795648

CATA:

118259617 118259630

AFUL:

116485356 116502165

TGU:	100221796 100222616 100224801 100226600 100229676 100230182 100230310 105759945 115492572 115492576 115492597 115494525 116806618 116808091

LSR:	110471229 110473210 110479258 110479484 110480942 110482998 110483008 110483013 110483020 116184413

SCAN:

103819459 103821213 103821538 103821544 103821545 103821704 103822492 103826285 115484943 115484944 115484945 115485249 115485250

PMOA:

120496586 120498862 120498864 120498865 120498866 120500129 120502776 120509454 120512090

OTC:	121334138 121334139 121334140 121334141 121334143 121334176 121334177 121334178 121334180 121337836 121338543 121339675 121339796 121347555 121347803 121347903

PRUF:

121351071 121355021 121355048 121355049 121355079 121356475 121356480 121358543 121358661 121358663 121358665 121358666 121362311 121363619 121365244

ATRC:

139585640 139585644 139587622 139587663 139587664 139588633 139589413 139589418 139589438 139589475 139592089 139600308 139600316 139600319 139600326 139600336 139601538

GFR:	102032254 102032420 102034420 102034591 102034751 102034910 102036222 102039449 102040074 102040400 102042777

FAB:	101805845 101806079 101806420 101807419 101810525(ACR) 101810913 101813807 101815502 101821184 101821498 101822159

OMA:	130248527 130248529 130248530 130248713 130250517 130250519 130250522 130250523 130250524 130250525 130252239 130262551 130263069 130264157 130265236 130265655

PHI:	102099449 102100182 102100356 102100726 102100912 102101252 102103033 102104135 102104469 102106778 102109508 102109747 102110299 102110481 102112356 106628778

PMAJ:

107198756 107199113 107201238 107201239 107203286 107204160 107204248 107215191 107215761 107215800

CCAE:

111923201 111926213 111926214 111926220 111926221 111926222 111926224 111928838 111940106 111940691 111941730 111942340 111944320 111945825

CCW:	104685158 104685740 104689773 104697239 104697783 120411926

CBRC:

103612817 103612821 103612825 103614592 103616380 103617098 103622407 103624576

ACOE:

138099179 138100218 138103526 138104447 138104451 138104509 138104510 138107181 138107182 138107184 138107185 138107186 138107805 138107807 138107809 138109456 138120518

ETL:	114056934 114056935 114057344 114060836(ACR) 114069705 114070062 114070831 114072025 114072026

ZAB:	102063828 102064750 102066368 102070519 102071220 102071394 102071579 102072285 102073834 113460530

ZLE:	135441487 135442849 135442874 135442879 135444992 135444993 135444994 135444995 135444996 135444997 135445151 135445153 135447398 135458291 135458550 135458666 135458674 135459805 135459828

ACHL:

103801502 103801658 103801918 103803315 103805198 103808654

SVG:	106853546 106855615 106855676 106859658 106861997 106862003 106862021 106862952 106862953 106864001

MMEA:

130577607 130579218 130579476 130579838 130581446 130585769 130585773 130585810 130586619 130587811

HRT:	120748066 120749750 120749752 120749754 120749758 120749760 120749761 120749762 120751486 120752061 120753126 120763828 120765488 120765605

SATI:

136358482 136358483 136358559 136358560 136358561 136358562 136358563 136358565 136358566 136358567 136361207 136361555 136361557 136361619 136362000 136362001 136372112 136373638 136374294

FPG:

101920858

FCH:	102053562 102058125

NNT:	104406223 104408143

SHAB:

115601755(ACR)

ACUN:

113479662 113487369 113487370 113489756 113490271 113490487 113490852 113490873 113490890 113490949

ACHC:

115341357 115341358 115342214(ACR)

HALD:

104322403(ACR)

HLE:	104833452(ACR)

AGEN:

126044256 126044257

HHAR:

128142596 128142597 128142603

LDI:	104348808 104349430

DPUB:

104300448 104300680 104306213

PPUS:

135174780(ACR) 135176416 135176417 135179785 135179786 135179787 135191808

EGZ:

NNI:

PCRI:

PCAO:

PADL:

103924103(ACR)

AFOR:

103893174 103895289(ACR)

FGA:

104077990

CBOY:

140643558 140643574 140649100 140649205 140649210 140651919

CLV:	102087611 102095569(ACR) 106145737

CNIC:

135995929 135999470 135999615

MUI:

104545267

PGUU:

104460770

PLET:

104627099

CMAC:

104475581 104478175 104482174

CUCA:

104061494 128849706 128850158 128850744 128850856 128852481 128852499 128852510 128852640 128852655 128852671 128852675 128852683 128853739 128853790

ACAR:

104523418 104527929

CPEA:

104388655 104389105 104389332 104391094(ACR)

RTD:	128900496 128902883 128904288 128910479

CRID:

134510472(ACR) 134511374 134512303 134512370

AAM:

106496144

AROW:

112968660 112968683

NPD:	112953970 112953971

DNE:	112989979 112989984

SCAM:

104145754

ASN:	102370826 102371080 102384412

AMJ:	102561178 102574978 106737926

GGN:	109292091(ACR)

PSS:	102455380 102455626 106731832

CMY:	102938344(ACR)

CCAY:

125625502 125637426

DCC:	119861292 119861356

CPIC:

101943992

TST:	117873481 117873487

CABI:

116838331 116838335

MRV:	120393791 120396067

ACS:	100558380 107983695

ASAO:

132775562 132775563 132775564 132775565

PVT:	110070564 110070565 110070568 110070571 110084405 110084406 110084408(ACR) 110084420

SUND:

121930811 121930815 121932298 121932299(ACR) 121932300

PBI:	103055962 103067049 107326529 112542530 112542531

PMUR:

107297332 114923114 114923390 114923503

CTIG:

120303703 120320074

TSR:

106547407

PGUT:

117672950 117672959 117672961 117672962 117676845

PCAE:

139319678 139319953

APRI:

131202625 131202626

PTEX:

113451581 113451582 113451583

NSS:	113427774 113427776 113429754

VKO:	123023716(ACR)

PMUA:

114604849 114604850 114604851 114604852 114604853 114604859 114606012

PRAF:

128421954 128421972 128421986 128421988 128421990

ZVI:	118091564 118091572 118091573 118091575

HCG:	128328407 128328408

GJA:	107118562(ACR) 107120174

STOW:

125434607 125434608

EMC:	129335733 129335736 129335737

XLA:	108695414 108695553(acr.2.L) 108707440 108707950 108713848 108714853 108719368 108719374 734611(XB5892359.L)

XTR:	100487305 100487784 100490933 100497024 100497408 100497443 101731233 101732810 101733280 108645680 108645681(acr.2) 108647852 116408674 116408790 116411577 116411715 116412122 733551

NPR:

108802724

RTEM:

120916063 120920625 120930362

ACAT:

141133926

BBUF:

120986103 120986112 120986123

BGAR:

122925776 122925777

DTC:	141063509 141095089 141095091 141095093 141100521 141100522

PWL:

138288580

MUO:	115479025 115479026

GSH:	117366883 117367084

PSPA:

121299590 121300198 121318214

ARUT:

117419697 117426277 117965962

LCM:

102354559

CMK:	103182529 103190823

CPLA:

HOC:

LERI:

HAKA:

NLU:

TCF:

ABRU:

HRF:

OED:

LJP:

Reference

PMID:22729485

Authors

Ferrer M, Rodriguez H, Zara L, Yu Y, Xu W, Oko R

Title

MMP2 and acrosin are major proteinases associated with the inner acrosomal membrane and may cooperate in sperm penetration of the zona pellucida during fertilization.

Journal

Cell Tissue Res 349:881-95 (2012)
DOI:10.1007/s00441-012-1429-1

Reference

PMID:2493394

Authors

Baba T, Watanabe K, Kashiwabara S, Arai Y

Title

Primary structure of human proacrosin deduced from its cDNA sequence.

Journal

FEBS Lett 244:296-300 (1989)
DOI:10.1016/0014-5793(89)80549-6

Sequence

[hsa:49]

LinkDB

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