KEGG   ORTHOLOGY: K05611
Entry
K05611                      KO                                     

Name
UCHL1
Definition
ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]
Pathway
ko05012  Parkinson disease
ko05022  Pathways of neurodegeneration - multiple diseases
Disease
H00057  Parkinson disease
H00266  Hereditary spastic paraplegia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
   05022 Pathways of neurodegeneration - multiple diseases
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C12: ubiquitin C-terminal hydrolase family
   K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
Ubiquitin system [BR:ko04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UCH
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
Other DBs
GO: 0004843
Genes
HSA: 7345(UCHL1)
PTR: 461185(UCHL1)
PPS: 100978798(UCHL1)
GGO: 101150793(UCHL1)
PON: 100440914(UCHL1)
NLE: 100588568(UCHL1)
MCC: 701579(UCHL1)
MCF: 102133043(UCHL1)
CSAB: 103246177(UCHL1)
RRO: 104679224(UCHL1)
RBB: 108516888(UCHL1)
CJC: 100409098(UCHL1)
SBQ: 101052104(UCHL1)
MMU: 22223(Uchl1)
MCAL: 110294542(Uchl1)
MPAH: 110330551(Uchl1)
RNO: 29545(Uchl1)
MUN: 110547740(Uchl1)
CGE: 100766373(Uchl1)
NGI: 103729235(Uchl1)
HGL: 101702892(Uchl1)
CCAN: 109690785(Uchl1)
OCU: 100357806(UCHL1)
TUP: 102478017(UCHL1)
CFA: 479098(UCHL1)
VVP: 112919659(UCHL1) 112924918
AML: 100484886(UCHL1)
UMR: 103672780(UCHL1)
UAH: 113262438(UCHL1)
ORO: 101379197(UCHL1)
ELK: 111148969
FCA: 101093604(UCHL1)
PTG: 102949487(UCHL1)
PPAD: 109245853(UCHL1)
AJU: 106977844(UCHL1)
BTA: 514394(UCHL1)
BOM: 102282378(UCHL1)
BIU: 109560420(UCHL1)
BBUB: 102414729(UCHL1)
CHX: 102178714(UCHL1)
OAS: 101117250(UCHL1)
SSC: 396637(UCHL1)
CFR: 102514352(UCHL1)
CDK: 105089356(UCHL1)
BACU: 103007566(UCHL1)
LVE: 103069363(UCHL1)
OOR: 101283487(UCHL1)
DLE: 111170307(UCHL1)
PCAD: 102985886 102992459(UCHL1)
ECB: 100033838(UCHL1)
EPZ: 103566718(UCHL1)
EAI: 106841278(UCHL1)
MYB: 102262310(UCHL1)
MYD: 102769091(UCHL1)
MNA: 107532405(UCHL1)
HAI: 109381761(UCHL1)
DRO: 112316770(UCHL1)
PALE: 102881932(UCHL1)
RAY: 107518760(UCHL1)
MJV: 108391552(UCHL1)
LAV: 100662483(UCHL1)
TMU: 101353430
MDO: 100015629(UCHL1)
SHR: 100918150(UCHL1)
PCW: 110211607(UCHL1)
OAA: 114815493(UCHL1)
GGA: 770302(UCHL1)
MGP: 100549618(UCHL1)
CJO: 107313792(UCHL1)
NMEL: 110399164(UCHL1)
APLA: 101799480(UCHL1)
ACYG: 106048055(UCHL1)
TGU: 751589(UCHL1)
LSR: 110475493(UCHL1)
SCAN: 103826167(UCHL1)
GFR: 102037972(UCHL1)
FAB: 101809666(UCHL1)
PHI: 102104928(UCHL1)
PMAJ: 107202745(UCHL1)
CCAE: 111945483(UCHL1)
CCW: 104690880(UCHL1)
ETL: 114061161(UCHL1)
FPG: 101924718(UCHL1)
FCH: 102047483(UCHL1)
CLV: 102083724(UCHL1)
EGZ: 104128491(UCHL1)
NNI: 104020796(UCHL1)
ACUN: 113479207(UCHL1)
PADL: 103924019(UCHL1)
AAM: 106490166(UCHL1)
ASN: 102372366(UCHL1)
AMJ: 102576186(UCHL1)
PSS: 102451446(UCHL1)
CMY: 102945907(UCHL1)
CPIC: 101941582(UCHL1)
ACS: 100561831(uchl1)
PVT: 110075251(UCHL1)
PBI: 103058291(UCHL1)
PMUA: 114604170(UCHL1)
GJA: 107118479(UCHL1)
XLA: 108698136 735204(uchl1.L)
XTR: 496780(uchl1)
NPR: 108790863 108793718(UCHL1)
DRE: 325119(uchl1)
SANH: 107701450 107702299(uchl1)
IPU: 108260831(uchl1)
PHYP: 113544228(uchl1)
AMEX: 103023920(uchl1)
EEE: 113587695(uchl1)
TRU: 101069774(uchl1)
LCO: 104934202(uchl1)
NCC: 104942986(uchl1)
MZE: 101482896(uchl1)
ONL: 100534475(uchl1)
OLA: 101155828(uchl1)
XMA: 102233947(uchl1)
XCO: 114145390(uchl1)
PRET: 103459450(uchl1)
CVG: 107090463(uchl1)
NFU: 107395703
KMR: 108231227(uchl1)
ALIM: 106526179(uchl1)
AOCE: 111583015(uchl1)
CSEM: 103383638(uchl1)
POV: 109638250(uchl1)
LCF: 108893111(uchl1)
SDU: 111216625(uchl1)
SLAL: 111657345(uchl1)
HCQ: 109511321(uchl1)
BPEC: 110167608(uchl1)
MALB: 109955542(uchl1)
SASA: 100196868(uchl1)
OTW: 112240461
ELS: 105007816(uchl1)
SFM: 108924328(uchl1) 108930794
PKI: 111833704 111853044(uchl1)
LCM: 102365585(UCHL1)
CMK: 103175870(uchl1)
RTP: 109929852
CPV: cgd8_3200
 » show all
Reference
  Authors
Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr
  Title
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
  Journal
Cell 111:209-18 (2002)
DOI:10.1016/S0092-8674(02)01012-7
  Sequence
[hsa:7345]
Reference
PMID:2163617
  Authors
Day IN, Hinks LJ, Thompson RJ
  Title
The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase.
  Journal
Biochem J 268:521-4 (1990)
DOI:10.1042/bj2680521
  Sequence
[hsa:7345]
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