KEGG ORTHOLOGY: K08522

ORTHOLOGY: K08522

Entry

K08522                      KO

Symbol

CGA

Name

glycoprotein hormones alpha chain

Pathway

map04024

cAMP signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04912

GnRH signaling pathway

map04913

Ovarian steroidogenesis

map04917

Prolactin signaling pathway

map04918

Thyroid hormone synthesis

map04923

Regulation of lipolysis in adipocytes

map04929

GnRH secretion

map05320

Autoimmune thyroid disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K08522  CGA; glycoprotein hormones alpha chain
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K08522  CGA; glycoprotein hormones alpha chain
   04081 Hormone signaling
    K08522  CGA; glycoprotein hormones alpha chain
09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K08522  CGA; glycoprotein hormones alpha chain
   04929 GnRH secretion
    K08522  CGA; glycoprotein hormones alpha chain
   04912 GnRH signaling pathway
    K08522  CGA; glycoprotein hormones alpha chain
   04913 Ovarian steroidogenesis
    K08522  CGA; glycoprotein hormones alpha chain
   04917 Prolactin signaling pathway
    K08522  CGA; glycoprotein hormones alpha chain
   04918 Thyroid hormone synthesis
    K08522  CGA; glycoprotein hormones alpha chain
09160 Human Diseases
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K08522  CGA; glycoprotein hormones alpha chain
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K08522  CGA; glycoprotein hormones alpha chain
Cytokines and neuropeptides [BR:ko04052]
Neuropeptides
  GPCR binding
   K08522  CGA; glycoprotein hormones alpha chain

Other DBs

GO:

0016913

Genes

HSA:

1081(CGA)

PTR:	462868(CGA)

PPS:	100987945(CGA)

GGO:	101123865(CGA)

PON:	100462106(CGA)

PPYG:

129038799(CGA)

NLE:	100582786(CGA)

HMH:	116469471(CGA)

SSYN:

129470421(CGA)

MCC:	697859(CGA)

MCF:	102138376(CGA)

MTHB:

126951979

MNI:	105496166(CGA)

CSAB:

103240056(CGA)

CATY:

105589009(CGA)

PANU:

101023134(CGA)

TGE:	112622278(CGA)

MLEU:

105545831(CGA)

RRO:	104681605(CGA)

RBB:	108538506(CGA)

TFN:	117097051(CGA)

PTEH:

111538053(CGA)

CANG:

105511709(CGA)

CJC:	100389264(CGA)

SBQ:	101032263(CGA)

CIMI:

108311524(CGA)

ANAN:

105711484(CGA)

CSYR:

103270332(CGA)

MMUR:

105863640(CGA)

LCAT:

123633043(CGA)

PCOQ:

105805309(CGA)

OGA:	100945128(CGA)

MMU:	12640(Cga)

MCAL:

110293638(Cga)

MPAH:

110338938(Cga)

RNO:	116700(Cga)

MCOC:

116088974(Cga)

ANU:	117709376(Cga)

ASYL:

127679859(Cga)

MUN:	110551855(Cga)

CGE:	100689452(Cga)

MAUA:

101835965(Cga)

PROB:

127224456(Cga)

PLEU:

114699415(Cga)

MORG:

121458490(Cga)

MFOT:

126503682

AAMP:

119826871(Cga)

NGI:	103729473(Cga)

HGL:	101704979(Cga)

CPOC:

100135499(Cga)

CCAN:

109675369(Cga)

DORD:

105998206(Cga)

DSP:	122107797(Cga)

PLOP:

125357664(Cga)

NCAR:

124989487

MMMA:

107152608(Cga)

ITI:	101968327(Cga)

OCU:	100009481(CGA)

OPI:	101518768 101519006(CGA)

TUP:	102467691(CGA)

GVR:	103593408(CGA)

CFA:	403483(CGA)

CLUD:

112658584(CGA)

VVP:	112908403(CGA)

VLG:	121473332(CGA)

NPO:	129513092(CGA)

AML:	100480190(CGA)

UMR:	103659748(CGA)

UAH:	113264851(CGA)

UAR:	123776172(CGA)

ELK:

111158799

LLV:

125103297

MPUF:

101673443(CGA)

MNP:	132017446(CGA)

MLK:	131833124(CGA)

NVS:	122898732(CGA)

ORO:	101375408(CGA)

EJU:	114213056(CGA)

ZCA:	113927097(CGA)

MLX:	118000682(CGA)

NSU:	110583379(CGA)

LWW:	102737633(CGA)

FCA:	751819(CGA)

PYU:	121029152(CGA)

PCOO:

112862269(CGA)

PBG:	122488978(CGA)

PVIV:

125166053(CGA)

LRUF:

124528957

LGF:	123608697(CGA)

AJU:

106972533

PTG:	102954911(CGA)

PPAD:

109263275(CGA)

PUC:

125938682

PLEZ:

122219093(CGA)

HHV:	120221839(CGA)

BTA:	280749(CGA)

BOM:	102279387(CGA)

BIU:	109563646(CGA)

BBUB:

123464610(CGA)

BBIS:

104984761(CGA)

CHX:	102181038(CGA)

OAS:	443538(CGA)

BTAX:

128053493(CGA)

CSUM:

138089885(CGA)

ODA:	120862752(CGA)

CCAD:

122422505(CGA)

MREE:

136150888(CGA)

OVR:	110128372(CGA)

MBEZ:

129561194(CGA)

SSC:	406869(CGA)

CFR:	102519852(CGA)

CBAI:

105064141(CGA)

CDK:	105095553(CGA)

VPC:	102541684(CGA)

BACU:

103006767(CGA)

BMUS:

118905202(CGA)

LVE:	103072990(CGA)

OOR:	101271158(CGA)

LALB:

132530630(CGA)

DLE:	111168620(CGA)

PCAD:

102995513(CGA)

PSIU:

116763528(CGA)

NASI:

112392167(CGA)

ECB:	100034174(CGA)

EPZ:	103547763(CGA)

EAI:	106835849(CGA)

MYB:	102239335(CGA)

MYD:	102769451(CGA)

MMYO:

118660297(CGA)

MLF:	102427356(CGA)

MDT:	132236481(CGA)

MYUM:

139013124(CGA)

PKL:	118705579(CGA)

EFUS:

103290527(CGA)

MNA:	107532807(CGA)

DRO:	112297422(CGA)

SHON:

118982323(CGA)

AJM:	119048400(CGA)

PDIC:

114495040(CGA)

PHAS:

123822019(CGA)

MMF:	118621794(CGA)

PPAM:

129067135(CGA)

RFQ:	117020427(CGA)

PALE:

102890788(CGA)

PGIG:

120594818(CGA)

PVP:	105296996(CGA)

RAY:	107501740(CGA)

MJV:	108405582(CGA)

TOD:	119253381(CGA)

SARA:

101542391(CGA)

SFUM:

130033556(CGA)

SETR:

126006779(CGA)

LAV:	100673911(CGA)

TMU:

101345506

ETF:	101640405(CGA)

DNM:	101434262(CGA)

MDO:	554198(CGA)

GAS:	123247080(CGA)

SHR:	100915093(CGA)

AFZ:

127561975

PCW:	110200891(CGA)

TVP:	118858572(CGA)

PBRV:

138143794(CGA)

OAA:	100082555(CGA)

TACU:

119940942(CGA)

GGA:	421829(CGA)

PCOC:

116240641(CGA)

MGP:	100303682(CGA)

CJO:	107311949(CGA)

TPAI:

128086072(CGA)

LMUT:

125688810(CGA)

NMEL:

110395287(CGA)

APLA:

101793145(CGA)

ACYG:

106035416(CGA)

CATA:

118254319(CGA)

AFUL:

116488181(CGA)

TGU:	100227314(CGA)

LSR:	110479175(CGA)

SCAN:

103819392(CGA)

PMOA:

120511701(CGA)

OTC:	121340013(CGA)

PRUF:

121360522(CGA)

ATRC:

139592386(CGA)

GFR:	102039413(CGA)

FAB:	101808078(CGA)

OMA:	130251495(CGA)

PHI:	102102480(CGA)

PMAJ:

107201389(CGA)

CCAE:

111926069(CGA)

CCW:	104692463(CGA)

CBRC:

103621432(CGA)

ACOE:

138107346(CGA)

ETL:	114066615(CGA)

ZAB:	102073984(CGA)

ZLE:	135446336(CGA)

ACHL:

103811569(CGA)

SVG:	106854097(CGA)

MMEA:

130582160(CGA)

HRT:	120749785(CGA)

SATI:

136358394(CGA)

CCIC:

134041716(CGA)

FPG:	101920944(CGA)

FCH:	102047327(CGA)

CCRI:

104156610(CGA)

NNT:	104409954(CGA)

SHAB:

115609626(CGA)

ACUN:

113478295(CGA)

TALA:

104356711(CGA)

ACHC:

115333740(CGA)

HALD:

104319285(CGA)

HLE:	104830645(CGA)

AGEN:

126046081

HHAR:

128139342(CGA)

GCL:

127015121

CSTI:

104560361(CGA)

LDI:	104341971(CGA)

MNB:	103774247(CGA)

DPUB:

104306610(CGA)

PPUS:

135189198(CGA)

AVIT:

104269628(CGA)

BRHI:

104496225(CGA)

EGZ:	104135351(CGA)

NNI:	104021959(CGA)

PCRI:

104026516(CGA)

PCAO:

104050176(CGA)

PADL:

103924571(CGA)

AFOR:

103901116(CGA)

FGA:	104072080(CGA)

GSTE:

104252915(CGA)

CBOY:

140649982(CGA)

CLV:	102090935(CGA)

MUI:	104535611(CGA)

PGUU:

104463238(CGA)

PLET:

104627102(CGA)

EHS:	104510117(CGA)

CMAC:

104475034(CGA)

CUCA:

104062693(CGA)

TEO:	104383281(CGA)

BREG:

104635521(CGA)

OHA:	104330424(CGA)

ACAR:

104524397(CGA)

CPEA:

104391267(CGA)

CVF:	104288652(CGA)

RTD:	128906927(CGA)

CRID:

134513407(CGA)

AAM:	106489639(CGA)

AROW:

112964479(CGA)

NPD:	112946582(CGA)

TGT:	104564661(CGA)

DNE:	112979318(CGA)

SCAM:

104139913(CGA)

ASN:	102369642(CGA)

AMJ:	102563579(CGA)

CPOO:

109311841(CGA)

GGN:	109299891(CGA)

PSS:	102457567(CGA)

CMY:	102931360(CGA)

CCAY:

125634399(CGA)

DCC:	119853553(CGA)

CPIC:

101931903(CGA)

TST:	117875648(CGA)

CABI:

116819829(CGA)

MRV:	120401391(CGA)

ACS:	100557664(cga)

ASAO:

132762038(CGA)

PVT:	110077363(CGA)

SUND:

121917349 121917455

PBI:	103061936(CGA)

PMUR:

107284754(CGA)

CTIG:

120307855(CGA)

PGUT:

117660741(CGA)

APRI:

131188919(CGA)

PTEX:

113455406(CGA)

NSS:	113411450(CGA)

VKO:	123019295(CGA)

PMUA:

114593929(CGA)

PRAF:

128410318(CGA)

ZVI:	118082872(CGA)

HCG:	128341124(CGA)

GJA:	107121763(CGA)

STOW:

125431784(CGA)

EMC:	129328599(CGA)

XLA:	378681(cga.S) 432256(cga.L)

XTR:	100488153(cga)

NPR:	108785310(CGA)

RTEM:

120937093(CGA)

BBUF:

120998167(CGA)

BGAR:

122936191(CGA)

PWL:	138297385(CGA)

MUO:	115465242(CGA)

GSH:	117357993(CGA)

DRE:	402987(cga)

SRX:	107728960 107744957

SANH:

107672353(cga)

SGH:	107573322(cga)

CCAR:

109081150(cga) 122148212

CAUA:

113095973 113116998(cga)

CGIB:

128031495

PTET:

122361724(cga)

LROH:

127180244(cga)

OMC:	131523787(cga)

PPRM:

120462390(cga)

RKG:	130088925(cga)

MAMB:

125268196(cga)

CIDE:

127498603

CERY:

137007123(cga)

MASI:

127454921

TROS:

130560854(cga)

TDW:	130436833(cga)

MANU:

129417427(cga)

PDAB:

135748963(cga)

IPU:	100304479(cga)

IFU:	128612732(cga)

PHYP:

113538808(cga)

SMEO:

124390138(cga)

TFD:	113659675(cga)

TVC:	132852328(cga)

CGAR:

128535897(cga)

NGRA:

132893958(cga)

TRN:	134324921(cga)

AMEX:

103028076(cga)

CMAO:

118823510(cga)

EEE:	113572662(cga)

CHAR:

105896037(cga)

SPIL:

134060208 134067745(cga)

TRU:	101075135(cga)

TFS:	130513274(cga)

TNG:	GSTEN00032138G001

LCO:	104922151(cga)

NCC:	104945545(cga)

TBEN:

117497981(cga)

CGOB:

115027197(cga)

PGEO:

117467854(cga)

GACU:

117549964(cga)

EMAC:

134881595(cga)

ELY:	117266815 117266817(cga)

EFO:	125901164(cga)

PLEP:

121953465(cga)

SLUC:

116035667(cga)

ECRA:

117936361(cga)

ESP:	116670087(cga)

PFLV:

114546598(cga)

GAT:	120833424(cga)

PPUG:

119228123(cga)

AFB:	129103267(cga)

CLUM:

117751466(cga)

PSWI:

130201476(cga)

CANA:

137787562(cga)

CVE:	137884538(cga) 137890232

MSAM:

119909832(cga)

SCHU:

122861404(cga)

CUD:	121526247(cga)

SPUL:

138590965(cga)

LMIX:

132993405(cga)

ALAT:

119004618(cga)

ASTR:

137610860(cga)

MZE:	101464445(cga)

ONL:	100534503(cga)

OAU:	116334742(cga)

OLA:	100144350(cga)

OML:	112150314(cga)

CSAI:

133461972(cga)

XMA:	102222175(cga)

XCO:	114134705(cga)

XHE:	116708546(cga)

PRET:

103458809(cga)

PFOR:

103153293(cga)

PLAI:

106945634(cga)

PMEI:

106926302(cga)

GAF:	122845896(cga)

PPRL:

129374678(cga)

CVG:	107091324(cga)

CTUL:

119797779(cga)

GMU:	124855694(cga)

NFU:	107392255(cga)

KMR:	108236176(cga)

ALIM:

106521971(cga)

NWH:	119427391(cga)

AOCE:

111577951(cga)

EJA:	138199993(cga)

BFRE:

138633053(cga)

MCEP:

125023790(cga)

CSEM:

103378053(cga)

POV:	109627943(cga)

SSEN:

122783168(cga)

SSOE:

131444903(cga)

HHIP:

117756452(cga)

HSP:	118115927(cga)

PPLT:

128450872(cga)

SMAU:

118286258(cga)

LCF:

108874911

SDU:	111225463(cga)

SLAL:

111644793(cga)

XGL:	120795593(cga)

HCQ:	109507742(cga)

SSCV:

125980534(cga)

SBIA:

133513316(cga)

PEE:	133413040(cga)

PTAO:

133487785(cga)

BPEC:

110155579 110156402

ENY:

140370394

MALB:

109955066(cga)

BSPL:

114848865(cga)

SJO:	128375100(cga)

SSCO:

134000582(cga)

GMH:	115543754(cga)

SASA:

100136440(glha2) 100286517(glha1) 106610036 106610688

STRU:

115162552 115172139 115192044 115202069

OTW:	112231694 112256487 112262040 112262281

OMY:	100135808 110498128 110505305 118941356

OGO:	124001863 124012863 124046287

ONE:	115137690 115138932 115146561 115146673

OKI:	109893863 109894655 109900335 109903873

OKE:	118362297 118368504 118395337 127913424

OMM:	135506674 135508419 135526069

OCLA:

139374168 139374332 139419659

SALP:

111968361 112068117 112068548 112069922

SNH:	120023515 120035033 120051953 120059830

CCLU:

121545109 123484126 123484152 123485549

ELS:	105016032(cga)

OEP:	134026451(cga)

SFM:	108922770(cga)

PKI:	111857962(cga)

AANG:

118209618

AROT:

135253776(cga)

CCOG:

133134431 133134710

LOC:	102687678(cga)

PSPA:

121315434 121317611

ARUT:

117403278 117410805

PSEX:

120526828(cga)

LCM:	102359455(CGA)

CMK:	103178889(cga)

RTP:

CPLA:

HOC:

LERI:

PSYT:

Reference

PMID:22280541

Authors

Aussedat B, Fasching B, Johnston E, Sane N, Nagorny P, Danishefsky SJ

Title

Total synthesis of the alpha-subunit of human glycoprotein hormones: toward fully synthetic homogeneous human follicle-stimulating hormone.

Journal

J Am Chem Soc 134:3532-41 (2012)
DOI:10.1021/ja2111459

Reference

PMID:481597

Authors

Fiddes JC, Goodman HM

Title

Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.

Journal

Nature 281:351-6 (1979)
DOI:10.1038/281351a0

Sequence

[hsa:1081]

LinkDB

DBGET integrated database retrieval system