KEGG   ORTHOLOGY: K19448
Entry
K19448                      KO                                     
Symbol
UL39
Name
Simplexvirus ribonucleoside-diphosphate reductase large subunit [EC:1.17.4.1]
Pathway
map05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06524  Apoptosis
  Element
N00579  HSV ICP6 to extrinsic apoptotic pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit
Viral proteins [BR:ko03200]
 dsDNA viruses
  Human herpes simplex virus 1/2
   K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit
Other DBs
GO: 0004748
Genes
VG: 1487325(UL39) 1487434(UL39) 18533931(UL39) 19621683(UL39) 26828076(UL39) 26887604(AZ249_gp43) 2703361(UL39) 3190322(UL39) 32707792(UL39) 3850222(UL39) 9829317(UL39)
Reference
PMID:18990579
  Authors
Lembo D, Brune W
  Title
Tinkering with a viral ribonucleotide reductase.
  Journal
Trends Biochem Sci 34:25-32 (2009)
DOI:10.1016/j.tibs.2008.09.008
  Sequence
[vg:1487325]
Reference
PMID:29321311
  Authors
Mostafa HH, Thompson TW, Konen AJ, Haenchen SD, Hilliard JG, Macdonald SJ, Morrison LA, Davido DJ
  Title
Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation.
  Journal
J Virol 92:e01654-17 (2018)
DOI:10.1128/JVI.01654-17
  Sequence
[vg:2703361]
LinkDB

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