Loxodonta africana (African savanna elephant): 100658990
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Entry
100658990 CDS
T04351
Gene name
PLCG2
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
lav
Loxodonta africana (African savanna elephant)
Pathway
lav00562
Inositol phosphate metabolism
lav01100
Metabolic pathways
lav01521
EGFR tyrosine kinase inhibitor resistance
lav04012
ErbB signaling pathway
lav04014
Ras signaling pathway
lav04020
Calcium signaling pathway
lav04062
Chemokine signaling pathway
lav04064
NF-kappa B signaling pathway
lav04066
HIF-1 signaling pathway
lav04070
Phosphatidylinositol signaling system
lav04072
Phospholipase D signaling pathway
lav04360
Axon guidance
lav04370
VEGF signaling pathway
lav04380
Osteoclast differentiation
lav04611
Platelet activation
lav04613
Neutrophil extracellular trap formation
lav04625
C-type lectin receptor signaling pathway
lav04650
Natural killer cell mediated cytotoxicity
lav04662
B cell receptor signaling pathway
lav04664
Fc epsilon RI signaling pathway
lav04666
Fc gamma R-mediated phagocytosis
lav04670
Leukocyte transendothelial migration
lav04722
Neurotrophin signaling pathway
lav04750
Inflammatory mediator regulation of TRP channels
lav04919
Thyroid hormone signaling pathway
lav04933
AGE-RAGE signaling pathway in diabetic complications
lav04935
Growth hormone synthesis, secretion and action
lav05167
Kaposi sarcoma-associated herpesvirus infection
lav05169
Epstein-Barr virus infection
lav05170
Human immunodeficiency virus 1 infection
lav05171
Coronavirus disease - COVID-19
lav05200
Pathways in cancer
lav05205
Proteoglycans in cancer
lav05206
MicroRNAs in cancer
lav05214
Glioma
lav05223
Non-small cell lung cancer
lav05225
Hepatocellular carcinoma
Module
lav_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
lav00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100658990 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
100658990 (PLCG2)
04014 Ras signaling pathway
100658990 (PLCG2)
04370 VEGF signaling pathway
100658990 (PLCG2)
04064 NF-kappa B signaling pathway
100658990 (PLCG2)
04066 HIF-1 signaling pathway
100658990 (PLCG2)
04020 Calcium signaling pathway
100658990 (PLCG2)
04070 Phosphatidylinositol signaling system
100658990 (PLCG2)
04072 Phospholipase D signaling pathway
100658990 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100658990 (PLCG2)
04613 Neutrophil extracellular trap formation
100658990 (PLCG2)
04625 C-type lectin receptor signaling pathway
100658990 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
100658990 (PLCG2)
04662 B cell receptor signaling pathway
100658990 (PLCG2)
04664 Fc epsilon RI signaling pathway
100658990 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
100658990 (PLCG2)
04670 Leukocyte transendothelial migration
100658990 (PLCG2)
04062 Chemokine signaling pathway
100658990 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
100658990 (PLCG2)
04919 Thyroid hormone signaling pathway
100658990 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
100658990 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
100658990 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
100658990 (PLCG2)
04380 Osteoclast differentiation
100658990 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100658990 (PLCG2)
05206 MicroRNAs in cancer
100658990 (PLCG2)
05205 Proteoglycans in cancer
100658990 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
100658990 (PLCG2)
05214 Glioma
100658990 (PLCG2)
05223 Non-small cell lung cancer
100658990 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100658990 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100658990 (PLCG2)
05171 Coronavirus disease - COVID-19
100658990 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
100658990 (PLCG2)
05169 Epstein-Barr virus infection
100658990 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100658990 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
lav04131
]
100658990 (PLCG2)
Enzymes [BR:
lav01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
100658990 (PLCG2)
Membrane trafficking [BR:
lav04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
100658990 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
100658990 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
C2
SH3_1
SH3_9
PH
SH3_2
PH_12
PH_14
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
100658990
NCBI-ProteinID:
XP_003418136
UniProt:
G3SPA6
LinkDB
All DBs
Position
Unknown
AA seq
1265 aa
AA seq
DB search
MTTMVSVDTLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKSSKDFERAKTVRQKEDCCFTIFYGTQFVLSTLSLAADSKEDAV
KWLSGLKILHQEAMSASTPTVIESWLRKQIYSVDQTRRNSISLRELKTILPMVNFKVSSA
KLLKDKFVEIGAHRDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGSTDRPDASA
VHLHDFQRFLLHEQQEVWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVEMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYVRSLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEQHCSVEQQRYMAKV
FKEVLDDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEELPQDTPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCAESGGKDGTFLVRESETYPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLMFTSIYALIQHYRESHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRVPRDGAFLVRKREGADSYAITFRARSKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMKLRYPVTPELLERYNMERDVNSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGARIQQYFPSNYVEDISTVDVDELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIVRQKPIDLLKYNQKGLTRVYPKGQRVDSSNYDPLRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPLPPEPQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWASTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgacgaccatggtcagcgtggacacccttccggagtatgagaagagtcagatcaagagg
gccctggagctggggacggtgatgaccgtgttcagcttccgcaagtccacgcctgagcgc
cggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagacggctgacaag
atcgagggctttttggatatcatggaaataaaggagatccgcccagggaaaagctccaag
gactttgagcgtgcaaaaacagtccgccagaaagaagactgctgcttcaccattttctat
ggcacccagtttgtcctcagcacactaagtttagcagcggactctaaggaggatgcagtt
aagtggctttcgggcttgaagatcttacaccaagaagcaatgagcgcctccacacccacg
gttattgagagttggctgagaaagcagatttattctgtggatcaaaccaggagaaacagc
atcagcctccgagagttgaagaccatcttgcccatggtcaactttaaagtgagcagtgcc
aagctcctcaaagataagtttgtggaaataggcgcgcacagagatgagctcagctttgaa
cagttccatctcttctataaaaaactcatgtttgaacagcaaaaatcgattcttgacgaa
ttcaagaaagattcttccgtcttcatcctggggagcaccgaccggccagatgcctccgct
gttcacctgcacgacttccagaggtttctcttacatgaacagcaggaggtttgggctcag
gatctaaacaaagtccgcgagcggatgaccaagtttattgatgacacaatgagggaaacg
gctgagcccttcttgtttgttgatgagttcctcacatacctgttctcacgagaaaacagt
atctgggatgagaagtatgatgtggtcgagatgcaggacatgaataaccccttgtctcac
tactggatctcctcttcacataacacgtatctcacgggtgaccagctgcggagcgagtcg
tccacggaggcatacgtccgctctctgcgaatgggctgtcgctgcattgagctggactgc
tgggatgggccagacgggaaacccattatctaccatggctggacgaggaccaccaagatc
aagtttgacgatgttgtgcaggccatcaaagaccacgcctttgtcacctcaagcttcccc
gtgatcctgtccattgagcagcactgcagtgtggagcagcagcgctacatggccaaggtg
ttcaaggaggtgctggatgacctgctgctcaccaagcccacggaggccagcgccgaccag
ctgccctcgcccagccagctgcgtgagaagatcattatcaagcataagaagctaggcccc
cgaggcgatgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggtgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgcgctattgctgat
gccaagctgtccttcagtgatgatattgagcagacagttgaagaggagctgccccaggac
acgccccccacagagctgcactttggggagaagtggttccacaaaaaggttgaaaagagg
accagtgccgagaagctgctgcaggagtactgtgctgagtcggggggcaaggacgggacc
ttcttggtgcgggagagtgagacctaccccaacgactacacgctgtccttctggcggtcg
ggccgggtccagcactgccgcatccggtccaccatggagggcgggaccctgaagtactac
ctgactgacaacctcatgttcaccagcatctatgccctcatccagcactaccgcgagagc
cacctgcgctgcgctgagttcgagctgcggctcaccgaccccgtgcccaaccccaacccg
cacgagtcgaagccgtggtactacgacagtctgagccgtggggaagcagaggacatgctg
atgagggtcccccgggacggggccttcctggtacggaagcgagaaggtgctgattcctac
gccatcaccttcagggccaggagcaaggtgaagcactgtcgcatcaaccgggacggccga
cactttgtgctggggacctcagcctacttcgagagcctggtggagctggtcagctactat
gagaagcacgcgctctaccgcaagatgaagctgcgctaccctgtgacccctgagctactg
gagcgctacaacatggaaagagatgtaaactccctctatgacgtcagcaggatgtatgtg
gatccaagtgaaatcaatccttccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgacgagcttagcttctgccgtggtgctctcatccacaatgtctcc
aaggagcctgggggctggtggaaaggtgactatggggcccgaatccagcagtacttcccg
tcgaactatgtcgaggacatttcaacagttgacgtcgacgagctagaaaagcagatcatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagccccacaagggaaaaaccagaagtctttcgtcttcatcctggagcccaagaag
cagggtgaccccccggtggagttcgccacagacagggtggaggagctctttgagtggttc
cagagcatccgagagatcacctggaagatcgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtcaatcgccattgagctctctgatctggttgtctactgcaaaccaacc
agcaaaaccaaggataacttagaaaaccccgacttccgagaaatccgctccttcgtggag
accaaggcagacagcatcgtcagacagaagcccatcgatctcctgaagtacaaccagaag
ggcctgacccgtgtttaccccaagggacaaagggttgactcttcaaactatgaccctctt
cgcctctggctatgtggctcccagatggtggcgctcaacttccagacggcagataagtac
atgcagatgaatcacgccttattttccctcaatgggcgaacgggctacgtcctacagccc
gagagcatgaggaccgagaagtatgaccccctgccgcccgagccccagaggaagatcctg
atgactctgacagtcaaggttctcggcgcccgccatctccccaagctcggacgaagcatc
gcctgtccttttgtagaggtggaaatatgtggagccgagtatgacaacaacaagtttaag
acaacagttgtgaatgataatggcttaagtcctgtctgggcttcaacacaggagaaggtg
acgtttgaaatttatgacccaaacctcgcgtttctgcgctttgtggtttacgaggaagat
atgttcagcgatcccaacttccttgctcatgctacttaccccattaagggaatcaaatca
ggatttagatcagttcctctcaagaacgggtacagtgaagacatagagctggcgtccctc
ctggttttctgtgaaatgcggcctgtcctggagagtgaagaggaactttactcctcctgt
cgccagctgcggaggcggcaagaagagctgaacaaccagctctttttgtatgacacacac
cagaacttacgcaacgccaaccgggacgccctggttaaggagttcaatgtcaatgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttgagagagaagagagtcagcaac
agcaagttttactcatag
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integrated database retrieval system
