KEGG T04351: 100662511

KEGG Orthology (KO) [BR:lav00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100662511 (MAP2K6)
   04015 Rap1 signaling pathway
    100662511 (MAP2K6)
   04668 TNF signaling pathway
    100662511 (MAP2K6)
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    100662511 (MAP2K6)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100662511 (MAP2K6)
   04664 Fc epsilon RI signaling pathway
    100662511 (MAP2K6)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100662511 (MAP2K6)
   04935 Growth hormone synthesis, secretion and action
    100662511 (MAP2K6)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100662511 (MAP2K6)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100662511 (MAP2K6)
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100662511 (MAP2K6)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    100662511 (MAP2K6)
   05022 Pathways of neurodegeneration - multiple diseases
    100662511 (MAP2K6)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100662511 (MAP2K6)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100662511 (MAP2K6)
   05135 Yersinia infection
    100662511 (MAP2K6)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100662511 (MAP2K6)
   05161 Hepatitis B
    100662511 (MAP2K6)
   05163 Human cytomegalovirus infection
    100662511 (MAP2K6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100662511 (MAP2K6)
   05169 Epstein-Barr virus infection
    100662511 (MAP2K6)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100662511 (MAP2K6)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lav01001]
    100662511 (MAP2K6)
Enzymes [BR:lav01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100662511 (MAP2K6)
Protein kinases [BR:lav01001]
Serine/threonine kinases: STE group
  STE7 family
   100662511 (MAP2K6)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Kinase-like Seadorna_VP7 Pkinase_fungal DUF4344 Choline_kinase APH

Other DBs

NCBI-GeneID:

100662511

NCBI-ProteinID:

XP_003417334

UniProt:

G3UEC7

LinkDB

Position

Unknown

AA seq 334 aa
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKSQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKATDVATFVKLILGD

NT seq 1005 nt +upstreamnt +downstreamnt
atgtctcagtcgaaaggcaagaagcgaaaccctggccttaagatccccaaagaagcattt
gaacaacctcagaccagttccacgccacctcgagatttagactctaaggcttgcatttct
attggaaatcagaactttgaagtgaaggctgatgacctagagcctataatggaactgggg
cgaggggcgtacggcgtggtggagaagatgcggcatgtgcccagtgagcagatcatggcg
gtgaagcggatccgggccacagtaaatagccaggagcagaaaaggctactgatggatttg
gatatttccatgaggacagtggactgtccttttacagtcaccttttatggcgcactcttc
cgggagggtgatgtgtggatttgcatggagctcatggatacatcactagataaattctat
aagcaagtcatcgataaaagccaaacgattccagaggacatcttagggaaaatagcagtt
tctattgttaaggcattagaacacttacacagtaagctgtctgtgattcatcgagacgtc
aagccttcgaacgtgctgatcaatgctctgggccaagtgaagatgtgtgattttggaatc
agcggctaccttgtggactctgttgctaaaacgatcgacgcaggctgcaaaccctacatg
gctcctgaacgaataaacccagagctcaaccagaagggatacagtgtgaaatctgacatt
tggagtcttggcatcacaatgattgagttggccatcctccggtttccctatgattcatgg
ggaaccccctttcagcagctcaaacaggtggtagaagagccatcgccacagctcccagca
gacaagttctccgcagagtttgttgactttacctcacagtgcttgaagaagaattccaaa
gaaaggccaacgtatccagagcttatgcaacatccttttttcaccctacacgaatccaaa
gcaacagatgtggcaacttttgtaaaactgattcttggagactaa

Loxodonta africana (African savanna elephant): 100675607

Entry

100675607 CDS T04351

Gene name

MAP2K3

Definition

(RefSeq) dual specificity mitogen-activated protein kinase kinase 3 isoform X1

K04432

mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]

Organism

lav Loxodonta africana (African savanna elephant)

Pathway

lav04010

MAPK signaling pathway

lav04015

Rap1 signaling pathway

lav04218

Cellular senescence

lav04620

Toll-like receptor signaling pathway

lav04664

Fc epsilon RI signaling pathway

lav04668

TNF signaling pathway

lav04714

Thermogenesis

lav04750

Inflammatory mediator regulation of TRP channels

lav04912

GnRH signaling pathway

lav04935

Growth hormone synthesis, secretion and action

lav05014

Amyotrophic lateral sclerosis

lav05022

Pathways of neurodegeneration - multiple diseases

lav05132

Salmonella infection

lav05135

Yersinia infection

lav05145

Toxoplasmosis

lav05161

Hepatitis B

lav05169

Epstein-Barr virus infection

lav05170

Human immunodeficiency virus 1 infection

lav05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:lav00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100675607 (MAP2K3)
   04015 Rap1 signaling pathway
    100675607 (MAP2K3)
   04668 TNF signaling pathway
    100675607 (MAP2K3)
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    100675607 (MAP2K3)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100675607 (MAP2K3)
   04664 Fc epsilon RI signaling pathway
    100675607 (MAP2K3)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100675607 (MAP2K3)
   04935 Growth hormone synthesis, secretion and action
    100675607 (MAP2K3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100675607 (MAP2K3)
  09159 Environmental adaptation
   04714 Thermogenesis
    100675607 (MAP2K3)
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100675607 (MAP2K3)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    100675607 (MAP2K3)
   05022 Pathways of neurodegeneration - multiple diseases
    100675607 (MAP2K3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100675607 (MAP2K3)
   05135 Yersinia infection
    100675607 (MAP2K3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100675607 (MAP2K3)
   05161 Hepatitis B
    100675607 (MAP2K3)
   05169 Epstein-Barr virus infection
    100675607 (MAP2K3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100675607 (MAP2K3)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lav01001]
    100675607 (MAP2K3)
Enzymes [BR:lav01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100675607 (MAP2K3)
Protein kinases [BR:lav01001]
Serine/threonine kinases: STE group
  STE7 family
   100675607 (MAP2K3)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Kinase-like Seadorna_VP7 Pkinase_fungal APH Choline_kinase RIO1 DUF4344

Other DBs

NCBI-GeneID:

100675607

NCBI-ProteinID:

XP_010598520

UniProt:

G3U6S9

LinkDB

Position

Unknown

AA seq 347 aa
MESPASSQPPSAPQSKGKSRKKKDLRITCVSKPPPPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS

NT seq 1044 nt +upstreamnt +downstreamnt
atggagtcgcccgcctcgagccagccccccagcgcgccccagtccaaaggaaaatccagg
aagaagaaggacttacggataacctgtgtgtccaagcctccaccacccaaccccacgccc
ccccggaaccttgattccaggaccttcatcaccataggagaccggaacttcgaggtggaa
gccgatgacctggtgaccatctcggagctgggccgtggagcctatggggtagtggagaag
gtgcgacatgcccagagtggtaccatcatggctgtgaagcggattcgagccaccgtgaac
tcacaggagcagaagaggctgctcatggacttggacatcaacatgcggacagttgactgc
ttctacactgtcaccttctacggggccctcttcagagagggtgatgtgtggatctgtatg
gagcttatggacacctctctggataaattctaccggaaggtgctggacaaaaacatgaca
attccagaggatattttgggggagattgctgtgtcgattgtgagggccctggagcacctg
cacagcaaactctccgtgatccacagagacgtgaagccctccaatgtgctcatcaacaag
gagggccatgtgaagatgtgcgactttgggattagtggctacttggtggactccgtggct
aagactatggacgccggctgcaagccctacatggcccctgagagaatcaacccggagctg
aaccagaagggctacaatgtcaagtccgatgtctggagcctcggcatcacaatgattgag
atggccatcctgcggtttccttatgagtcctgggggaccccgttccaacagctgaagcag
gtggtagaggagccgtccccccagctcccagctgaccggttctctcctgagtttgtggac
ttcactgcacagtgcctgaggaagaaccccgcggagcgcatgagctacctggagctgatg
gagcaccctttcttcaccttgcacaaaaccaagaagacagacattgctgccttcgtgaag
gagatcctgggggaggactcgtag

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