KEGG   Loxodonta africana (African savanna elephant): 100665537
Entry
100665537         CDS       T04351                                 

Gene name
PRKCA
Definition
(RefSeq) protein kinase C alpha type isoform X1
  KO
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav01521  EGFR tyrosine kinase inhibitor resistance
lav04010  MAPK signaling pathway
lav04012  ErbB signaling pathway
lav04014  Ras signaling pathway
lav04015  Rap1 signaling pathway
lav04020  Calcium signaling pathway
lav04066  HIF-1 signaling pathway
lav04070  Phosphatidylinositol signaling system
lav04071  Sphingolipid signaling pathway
lav04072  Phospholipase D signaling pathway
lav04150  mTOR signaling pathway
lav04151  PI3K-Akt signaling pathway
lav04261  Adrenergic signaling in cardiomyocytes
lav04270  Vascular smooth muscle contraction
lav04310  Wnt signaling pathway
lav04360  Axon guidance
lav04370  VEGF signaling pathway
lav04510  Focal adhesion
lav04540  Gap junction
lav04613  Neutrophil extracellular trap formation
lav04650  Natural killer cell mediated cytotoxicity
lav04664  Fc epsilon RI signaling pathway
lav04666  Fc gamma R-mediated phagocytosis
lav04670  Leukocyte transendothelial migration
lav04713  Circadian entrainment
lav04720  Long-term potentiation
lav04723  Retrograde endocannabinoid signaling
lav04724  Glutamatergic synapse
lav04725  Cholinergic synapse
lav04726  Serotonergic synapse
lav04727  GABAergic synapse
lav04728  Dopaminergic synapse
lav04730  Long-term depression
lav04750  Inflammatory mediator regulation of TRP channels
lav04911  Insulin secretion
lav04912  GnRH signaling pathway
lav04916  Melanogenesis
lav04918  Thyroid hormone synthesis
lav04919  Thyroid hormone signaling pathway
lav04921  Oxytocin signaling pathway
lav04925  Aldosterone synthesis and secretion
lav04926  Relaxin signaling pathway
lav04928  Parathyroid hormone synthesis, secretion and action
lav04929  GnRH secretion
lav04933  AGE-RAGE signaling pathway in diabetic complications
lav04935  Growth hormone synthesis, secretion and action
lav04960  Aldosterone-regulated sodium reabsorption
lav04961  Endocrine and other factor-regulated calcium reabsorption
lav04970  Salivary secretion
lav04971  Gastric acid secretion
lav04972  Pancreatic secretion
lav05017  Spinocerebellar ataxia
lav05022  Pathways of neurodegeneration - multiple diseases
lav05031  Amphetamine addiction
lav05032  Morphine addiction
lav05143  African trypanosomiasis
lav05146  Amoebiasis
lav05161  Hepatitis B
lav05163  Human cytomegalovirus infection
lav05164  Influenza A
lav05170  Human immunodeficiency virus 1 infection
lav05171  Coronavirus disease - COVID-19
lav05200  Pathways in cancer
lav05205  Proteoglycans in cancer
lav05206  MicroRNAs in cancer
lav05214  Glioma
lav05223  Non-small cell lung cancer
lav05225  Hepatocellular carcinoma
lav05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100665537 (PRKCA)
   04012 ErbB signaling pathway
    100665537 (PRKCA)
   04014 Ras signaling pathway
    100665537 (PRKCA)
   04015 Rap1 signaling pathway
    100665537 (PRKCA)
   04310 Wnt signaling pathway
    100665537 (PRKCA)
   04370 VEGF signaling pathway
    100665537 (PRKCA)
   04066 HIF-1 signaling pathway
    100665537 (PRKCA)
   04020 Calcium signaling pathway
    100665537 (PRKCA)
   04070 Phosphatidylinositol signaling system
    100665537 (PRKCA)
   04072 Phospholipase D signaling pathway
    100665537 (PRKCA)
   04071 Sphingolipid signaling pathway
    100665537 (PRKCA)
   04151 PI3K-Akt signaling pathway
    100665537 (PRKCA)
   04150 mTOR signaling pathway
    100665537 (PRKCA)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100665537 (PRKCA)
   04540 Gap junction
    100665537 (PRKCA)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100665537 (PRKCA)
   04650 Natural killer cell mediated cytotoxicity
    100665537 (PRKCA)
   04664 Fc epsilon RI signaling pathway
    100665537 (PRKCA)
   04666 Fc gamma R-mediated phagocytosis
    100665537 (PRKCA)
   04670 Leukocyte transendothelial migration
    100665537 (PRKCA)
  09152 Endocrine system
   04911 Insulin secretion
    100665537 (PRKCA)
   04929 GnRH secretion
    100665537 (PRKCA)
   04912 GnRH signaling pathway
    100665537 (PRKCA)
   04921 Oxytocin signaling pathway
    100665537 (PRKCA)
   04926 Relaxin signaling pathway
    100665537 (PRKCA)
   04935 Growth hormone synthesis, secretion and action
    100665537 (PRKCA)
   04918 Thyroid hormone synthesis
    100665537 (PRKCA)
   04919 Thyroid hormone signaling pathway
    100665537 (PRKCA)
   04928 Parathyroid hormone synthesis, secretion and action
    100665537 (PRKCA)
   04916 Melanogenesis
    100665537 (PRKCA)
   04925 Aldosterone synthesis and secretion
    100665537 (PRKCA)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100665537 (PRKCA)
   04270 Vascular smooth muscle contraction
    100665537 (PRKCA)
  09154 Digestive system
   04970 Salivary secretion
    100665537 (PRKCA)
   04971 Gastric acid secretion
    100665537 (PRKCA)
   04972 Pancreatic secretion
    100665537 (PRKCA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100665537 (PRKCA)
   04961 Endocrine and other factor-regulated calcium reabsorption
    100665537 (PRKCA)
  09156 Nervous system
   04724 Glutamatergic synapse
    100665537 (PRKCA)
   04727 GABAergic synapse
    100665537 (PRKCA)
   04725 Cholinergic synapse
    100665537 (PRKCA)
   04728 Dopaminergic synapse
    100665537 (PRKCA)
   04726 Serotonergic synapse
    100665537 (PRKCA)
   04720 Long-term potentiation
    100665537 (PRKCA)
   04730 Long-term depression
    100665537 (PRKCA)
   04723 Retrograde endocannabinoid signaling
    100665537 (PRKCA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100665537 (PRKCA)
  09158 Development and regeneration
   04360 Axon guidance
    100665537 (PRKCA)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100665537 (PRKCA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100665537 (PRKCA)
   05206 MicroRNAs in cancer
    100665537 (PRKCA)
   05205 Proteoglycans in cancer
    100665537 (PRKCA)
   05231 Choline metabolism in cancer
    100665537 (PRKCA)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100665537 (PRKCA)
   05214 Glioma
    100665537 (PRKCA)
   05223 Non-small cell lung cancer
    100665537 (PRKCA)
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    100665537 (PRKCA)
   05022 Pathways of neurodegeneration - multiple diseases
    100665537 (PRKCA)
  09165 Substance dependence
   05031 Amphetamine addiction
    100665537 (PRKCA)
   05032 Morphine addiction
    100665537 (PRKCA)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100665537 (PRKCA)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100665537 (PRKCA)
   05161 Hepatitis B
    100665537 (PRKCA)
   05171 Coronavirus disease - COVID-19
    100665537 (PRKCA)
   05164 Influenza A
    100665537 (PRKCA)
   05163 Human cytomegalovirus infection
    100665537 (PRKCA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100665537 (PRKCA)
   05143 African trypanosomiasis
    100665537 (PRKCA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100665537 (PRKCA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lav01001]
    100665537 (PRKCA)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lav04131]
    100665537 (PRKCA)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     100665537 (PRKCA)
Protein kinases [BR:lav01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   100665537 (PRKCA)
Membrane trafficking [BR:lav04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    100665537 (PRKCA)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C C1_2 Kinase-like APH
Other DBs
NCBI-GeneID: 100665537
NCBI-ProteinID: XP_003417343
UniProt: G3SWW4
LinkDB
Position
Unknown
AA seq 671 aa
MADVFPSNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLRVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNEAFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSEDRKPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGT
EELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVN
GGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIAD
FGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYAKSVDWWAYGVLLYEMLAGQPPFDGE
DEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRID
WEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP
QFMHPILQSAV
NT seq 2016 nt   +upstreamnt  +downstreamnt
atggctgacgttttcccgtccaacgactccacggcgtctcaggacgtggccaaccggttc
gcccgcaaaggggcgctgaggcagaagaacgtgcacgaggtgaaggaccacaaattcatc
gcccgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctgggggttt
gggaaacaaggcttccagtgccaagtttgctgttttgtggttcacaagaggtgccatgag
tttgttactttttcttgcccgggtgccgataagggacctgacactgacgacccaaggagc
aagcacaaatttaaaatccacacttatggaagccccaccttctgtgatcattgtgggtca
ttgctgtacggactcattcaccaagggatgaaatgtgacacctgcgacatgaacgttcac
aagcagtgtgtaataaatgtccccagcctctgtggaatggatcacacagagaagagaggg
cgaatttacctgaaggctgaagttgctgatgagaagctccgcgtcacagtacgagatgca
aaaaatctaatccctatggatccaaatgggctttcagatccttacgtgaagctgaaactt
attcctgatcctaagaatgaaagcaaacaaaaaaccaaaaccatccgctctacactaaac
cctcagtggaatgaggccttcacattcaaattaaagccttcagacaaagaccgacgattg
tctgtagaaatctgggactgggatcgaacaacaagaaatgacttcatgggatccctttcc
tttggagtttcagagctgatgaagatgccggccagtggatggtacaagttgcttaaccaa
gaagaaggtgagtactacaatgtacccattccagaaggggatgaagaaggaaatatggag
ctcaggcagaaatttgagaaagccaagcttggccccgctgggaacaaagtgatcagtcct
tcagaagataggaaaccttccaacaacctggatcgagtaaaactcacggacttcaatttc
ctcatggtcctagggaaggggagttttggaaaggtgatgcttgctgacaggaagggcaca
gaagagctgtatgctatcaagattctcaagaaggacgtggtgatccaggatgacgacgtg
gagtgcaccatggtggagaagcgagttctggccctgctcgacaagcctccattcctgacg
cagctccactcctgcttccagacagtggatcgcctgtacttcgtcatggagtatgtcaac
ggtggggacctcatgtaccacattcagcaagtcgggaaatttaaggagccacaagcagta
ttctatgcagcagagatttccattggattgttctttcttcataaaagaggaatcatttat
agggatctgaaattagataatgtcatgctggattcggaaggacatatcaagattgccgac
tttgggatgtgcaaggagcacatgatggatggcgtcacaaccaggaccttctgtgggact
ccagattatattgccccggagataatcgcttatcagccgtatgcgaaatccgtggactgg
tgggcgtatggcgtcctattatacgaaatgctagctggccagcctccctttgatggcgaa
gatgaagatgaactctttcagtctataatggagcataacgtgtcctatccaaaatccttg
tccaaggaggccgtttccatctgcaaaggactgatgaccaaacaccccgccaagcggctg
ggctgtgggcctgagggtgagagggatgtaagagagcatgccttcttccggagaatcgac
tgggagaaactggagaaccgggagatccagccgccgttcaagcccaaagtgtgtggcaaa
ggagcagaaaactttgacaagttcttcacgcgagggcagcctgtcttaacgccgcctgac
cagctggtcattgctaatatagatcagtctgattttgaagggttctcatatgtcaacccc
cagtttatgcaccccatcttacagagcgcagtatga

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