KEGG   Lemur catta (Ring-tailed lemur): 123640770
Entry
123640770         CDS       T08326                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
lcat  Lemur catta (Ring-tailed lemur)
Pathway
lcat01522  Endocrine resistance
lcat04010  MAPK signaling pathway
lcat04015  Rap1 signaling pathway
lcat04068  FoxO signaling pathway
lcat04071  Sphingolipid signaling pathway
lcat04114  Oocyte meiosis
lcat04148  Efferocytosis
lcat04218  Cellular senescence
lcat04261  Adrenergic signaling in cardiomyocytes
lcat04370  VEGF signaling pathway
lcat04380  Osteoclast differentiation
lcat04550  Signaling pathways regulating pluripotency of stem cells
lcat04611  Platelet activation
lcat04613  Neutrophil extracellular trap formation
lcat04620  Toll-like receptor signaling pathway
lcat04621  NOD-like receptor signaling pathway
lcat04622  RIG-I-like receptor signaling pathway
lcat04625  C-type lectin receptor signaling pathway
lcat04657  IL-17 signaling pathway
lcat04658  Th1 and Th2 cell differentiation
lcat04659  Th17 cell differentiation
lcat04660  T cell receptor signaling pathway
lcat04664  Fc epsilon RI signaling pathway
lcat04668  TNF signaling pathway
lcat04670  Leukocyte transendothelial migration
lcat04714  Thermogenesis
lcat04722  Neurotrophin signaling pathway
lcat04723  Retrograde endocannabinoid signaling
lcat04728  Dopaminergic synapse
lcat04750  Inflammatory mediator regulation of TRP channels
lcat04912  GnRH signaling pathway
lcat04914  Progesterone-mediated oocyte maturation
lcat04917  Prolactin signaling pathway
lcat04926  Relaxin signaling pathway
lcat04932  Non-alcoholic fatty liver disease
lcat04933  AGE-RAGE signaling pathway in diabetic complications
lcat04935  Growth hormone synthesis, secretion and action
lcat04936  Alcoholic liver disease
lcat05014  Amyotrophic lateral sclerosis
lcat05020  Prion disease
lcat05022  Pathways of neurodegeneration - multiple diseases
lcat05132  Salmonella infection
lcat05133  Pertussis
lcat05135  Yersinia infection
lcat05140  Leishmaniasis
lcat05142  Chagas disease
lcat05145  Toxoplasmosis
lcat05152  Tuberculosis
lcat05161  Hepatitis B
lcat05163  Human cytomegalovirus infection
lcat05167  Kaposi sarcoma-associated herpesvirus infection
lcat05169  Epstein-Barr virus infection
lcat05170  Human immunodeficiency virus 1 infection
lcat05171  Coronavirus disease - COVID-19
lcat05205  Proteoglycans in cancer
lcat05208  Chemical carcinogenesis - reactive oxygen species
lcat05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lcat05415  Diabetic cardiomyopathy
lcat05417  Lipid and atherosclerosis
lcat05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lcat00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123640770 (MAPK12)
   04015 Rap1 signaling pathway
    123640770 (MAPK12)
   04370 VEGF signaling pathway
    123640770 (MAPK12)
   04668 TNF signaling pathway
    123640770 (MAPK12)
   04068 FoxO signaling pathway
    123640770 (MAPK12)
   04071 Sphingolipid signaling pathway
    123640770 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    123640770 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    123640770 (MAPK12)
   04218 Cellular senescence
    123640770 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    123640770 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123640770 (MAPK12)
   04613 Neutrophil extracellular trap formation
    123640770 (MAPK12)
   04620 Toll-like receptor signaling pathway
    123640770 (MAPK12)
   04621 NOD-like receptor signaling pathway
    123640770 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    123640770 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    123640770 (MAPK12)
   04660 T cell receptor signaling pathway
    123640770 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    123640770 (MAPK12)
   04659 Th17 cell differentiation
    123640770 (MAPK12)
   04657 IL-17 signaling pathway
    123640770 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    123640770 (MAPK12)
   04670 Leukocyte transendothelial migration
    123640770 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    123640770 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    123640770 (MAPK12)
   04917 Prolactin signaling pathway
    123640770 (MAPK12)
   04926 Relaxin signaling pathway
    123640770 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    123640770 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123640770 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    123640770 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    123640770 (MAPK12)
   04722 Neurotrophin signaling pathway
    123640770 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123640770 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123640770 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    123640770 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    123640770 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    123640770 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123640770 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    123640770 (MAPK12)
   05161 Hepatitis B
    123640770 (MAPK12)
   05171 Coronavirus disease - COVID-19
    123640770 (MAPK12)
   05163 Human cytomegalovirus infection
    123640770 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123640770 (MAPK12)
   05169 Epstein-Barr virus infection
    123640770 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123640770 (MAPK12)
   05135 Yersinia infection
    123640770 (MAPK12)
   05133 Pertussis
    123640770 (MAPK12)
   05152 Tuberculosis
    123640770 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    123640770 (MAPK12)
   05140 Leishmaniasis
    123640770 (MAPK12)
   05142 Chagas disease
    123640770 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    123640770 (MAPK12)
   05020 Prion disease
    123640770 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    123640770 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123640770 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    123640770 (MAPK12)
   05415 Diabetic cardiomyopathy
    123640770 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    123640770 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    123640770 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123640770 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    123640770 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lcat01001]
    123640770 (MAPK12)
Enzymes [BR:lcat01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     123640770 (MAPK12)
Protein kinases [BR:lcat01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   123640770 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 123640770
NCBI-ProteinID: XP_045411320
LinkDB
Position
6:690464..698274
AA seq 367 aa
MSSPPPARSGFYRQEVTKTAWDVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGTDHLDQLKEIMK
VTGTPSPEFVQRLQSADAKNYMKGLPELEKKDFASILTNASPLAVSLLEKMLVLDAEQRV
TAAEALAHPYFESLHDTEEAPAAQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRHLGTR
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcctgcccgcagtggcttttaccgccaggaggtgaccaagaccgcc
tgggacgtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctacggcgcg
gtgtgctcggccgtggacagccgcacgggcgccaaggtggccatcaagaagctgtaccgg
cccttccagtcagagctgtttgccaagcgcgcctaccgcgagctgcgcctcctcaaacac
atgcgccacgagaacgtgatcgggctgctggacgtgttcacgcctgacgagaccctggat
gacttcacagacttttacctggtgatgccgttcatggggaccgacctgggcaagctcatg
aagcacgagaagctgagtgaggaccggatccagttcctggtgtaccagatgctgaagggg
ctcaagtatatccacgctgctggcatcatccacagggacctgaagccgggcaacctagcg
gtgaatgaggactgtgagcttaagatcctggactttggcctggccaggcaggcagacagt
gagatgaccggatacgtggtgacgcggtggtaccgggcacccgaggtcatcttgaattgg
atgcgctacacgcagactgtggacatctggtccgtgggttgcatcatggctgagatgatt
acggggaagatactgttcaagggcaccgaccacctggaccagctgaaggagatcatgaag
gtgaccggcacgccgtcgcccgagtttgtgcagaggctgcagagtgcggatgcgaagaac
tacatgaagggcctccctgagctggagaagaaggactttgcctccatcctgaccaacgcc
agccccctggccgtgagcctcctggagaagatgctggtgctggatgcggagcagcgggtg
acggcggccgaggccctggcccacccctacttcgagtccctgcacgacacggaagaggcg
cctgcggcccagaagtacgacgactcctttgacgacgtggaccgcacgctggacgagtgg
aagcgtgtcacatacaaagaggtgctcagcttcaagccgcccaggcacctggggaccagg
gtttccaaggagacggctctgtga

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