KEGG   Manis javanica (Malayan pangolin): 108395842
Entry
108395842         CDS       T06054                                 

Gene name
KRAS
Definition
(RefSeq) GTPase KRas
  KO
K07827  GTPase KRas
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv01522  Endocrine resistance
mjv04010  MAPK signaling pathway
mjv04012  ErbB signaling pathway
mjv04014  Ras signaling pathway
mjv04015  Rap1 signaling pathway
mjv04062  Chemokine signaling pathway
mjv04068  FoxO signaling pathway
mjv04071  Sphingolipid signaling pathway
mjv04072  Phospholipase D signaling pathway
mjv04137  Mitophagy - animal
mjv04140  Autophagy - animal
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
mjv04211  Longevity regulating pathway
mjv04213  Longevity regulating pathway - multiple species
mjv04218  Cellular senescence
mjv04360  Axon guidance
mjv04370  VEGF signaling pathway
mjv04371  Apelin signaling pathway
mjv04540  Gap junction
mjv04550  Signaling pathways regulating pluripotency of stem cells
mjv04625  C-type lectin receptor signaling pathway
mjv04650  Natural killer cell mediated cytotoxicity
mjv04660  T cell receptor signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04714  Thermogenesis
mjv04720  Long-term potentiation
mjv04722  Neurotrophin signaling pathway
mjv04725  Cholinergic synapse
mjv04726  Serotonergic synapse
mjv04730  Long-term depression
mjv04810  Regulation of actin cytoskeleton
mjv04910  Insulin signaling pathway
mjv04912  GnRH signaling pathway
mjv04914  Progesterone-mediated oocyte maturation
mjv04915  Estrogen signaling pathway
mjv04916  Melanogenesis
mjv04917  Prolactin signaling pathway
mjv04919  Thyroid hormone signaling pathway
mjv04921  Oxytocin signaling pathway
mjv04926  Relaxin signaling pathway
mjv04929  GnRH secretion
mjv04933  AGE-RAGE signaling pathway in diabetic complications
mjv04935  Growth hormone synthesis, secretion and action
mjv04960  Aldosterone-regulated sodium reabsorption
mjv05010  Alzheimer disease
mjv05022  Pathways of neurodegeneration - multiple diseases
mjv05034  Alcoholism
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05163  Human cytomegalovirus infection
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05200  Pathways in cancer
mjv05203  Viral carcinogenesis
mjv05205  Proteoglycans in cancer
mjv05206  MicroRNAs in cancer
mjv05210  Colorectal cancer
mjv05211  Renal cell carcinoma
mjv05212  Pancreatic cancer
mjv05213  Endometrial cancer
mjv05214  Glioma
mjv05215  Prostate cancer
mjv05216  Thyroid cancer
mjv05218  Melanoma
mjv05219  Bladder cancer
mjv05220  Chronic myeloid leukemia
mjv05221  Acute myeloid leukemia
mjv05223  Non-small cell lung cancer
mjv05224  Breast cancer
mjv05225  Hepatocellular carcinoma
mjv05226  Gastric cancer
mjv05230  Central carbon metabolism in cancer
mjv05231  Choline metabolism in cancer
mjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108395842 (KRAS)
   04012 ErbB signaling pathway
    108395842 (KRAS)
   04014 Ras signaling pathway
    108395842 (KRAS)
   04015 Rap1 signaling pathway
    108395842 (KRAS)
   04370 VEGF signaling pathway
    108395842 (KRAS)
   04371 Apelin signaling pathway
    108395842 (KRAS)
   04068 FoxO signaling pathway
    108395842 (KRAS)
   04072 Phospholipase D signaling pathway
    108395842 (KRAS)
   04071 Sphingolipid signaling pathway
    108395842 (KRAS)
   04151 PI3K-Akt signaling pathway
    108395842 (KRAS)
   04150 mTOR signaling pathway
    108395842 (KRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108395842 (KRAS)
   04137 Mitophagy - animal
    108395842 (KRAS)
  09143 Cell growth and death
   04210 Apoptosis
    108395842 (KRAS)
   04218 Cellular senescence
    108395842 (KRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    108395842 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    108395842 (KRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108395842 (KRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    108395842 (KRAS)
   04650 Natural killer cell mediated cytotoxicity
    108395842 (KRAS)
   04660 T cell receptor signaling pathway
    108395842 (KRAS)
   04662 B cell receptor signaling pathway
    108395842 (KRAS)
   04664 Fc epsilon RI signaling pathway
    108395842 (KRAS)
   04062 Chemokine signaling pathway
    108395842 (KRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108395842 (KRAS)
   04929 GnRH secretion
    108395842 (KRAS)
   04912 GnRH signaling pathway
    108395842 (KRAS)
   04915 Estrogen signaling pathway
    108395842 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    108395842 (KRAS)
   04917 Prolactin signaling pathway
    108395842 (KRAS)
   04921 Oxytocin signaling pathway
    108395842 (KRAS)
   04926 Relaxin signaling pathway
    108395842 (KRAS)
   04935 Growth hormone synthesis, secretion and action
    108395842 (KRAS)
   04919 Thyroid hormone signaling pathway
    108395842 (KRAS)
   04916 Melanogenesis
    108395842 (KRAS)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    108395842 (KRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    108395842 (KRAS)
   04726 Serotonergic synapse
    108395842 (KRAS)
   04720 Long-term potentiation
    108395842 (KRAS)
   04730 Long-term depression
    108395842 (KRAS)
   04722 Neurotrophin signaling pathway
    108395842 (KRAS)
  09158 Development and regeneration
   04360 Axon guidance
    108395842 (KRAS)
  09149 Aging
   04211 Longevity regulating pathway
    108395842 (KRAS)
   04213 Longevity regulating pathway - multiple species
    108395842 (KRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    108395842 (KRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108395842 (KRAS)
   05206 MicroRNAs in cancer
    108395842 (KRAS)
   05205 Proteoglycans in cancer
    108395842 (KRAS)
   05203 Viral carcinogenesis
    108395842 (KRAS)
   05230 Central carbon metabolism in cancer
    108395842 (KRAS)
   05231 Choline metabolism in cancer
    108395842 (KRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108395842 (KRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108395842 (KRAS)
   05212 Pancreatic cancer
    108395842 (KRAS)
   05225 Hepatocellular carcinoma
    108395842 (KRAS)
   05226 Gastric cancer
    108395842 (KRAS)
   05214 Glioma
    108395842 (KRAS)
   05216 Thyroid cancer
    108395842 (KRAS)
   05221 Acute myeloid leukemia
    108395842 (KRAS)
   05220 Chronic myeloid leukemia
    108395842 (KRAS)
   05218 Melanoma
    108395842 (KRAS)
   05211 Renal cell carcinoma
    108395842 (KRAS)
   05219 Bladder cancer
    108395842 (KRAS)
   05215 Prostate cancer
    108395842 (KRAS)
   05213 Endometrial cancer
    108395842 (KRAS)
   05224 Breast cancer
    108395842 (KRAS)
   05223 Non-small cell lung cancer
    108395842 (KRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108395842 (KRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    108395842 (KRAS)
  09165 Substance dependence
   05034 Alcoholism
    108395842 (KRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    108395842 (KRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108395842 (KRAS)
   05170 Human immunodeficiency virus 1 infection
    108395842 (KRAS)
   05161 Hepatitis B
    108395842 (KRAS)
   05160 Hepatitis C
    108395842 (KRAS)
   05163 Human cytomegalovirus infection
    108395842 (KRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108395842 (KRAS)
   05165 Human papillomavirus infection
    108395842 (KRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108395842 (KRAS)
   01522 Endocrine resistance
    108395842 (KRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mjv04131]
    108395842 (KRAS)
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:mjv04031]
    108395842 (KRAS)
Membrane trafficking [BR:mjv04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    108395842 (KRAS)
GTP-binding proteins [BR:mjv04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    108395842 (KRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 MeaB FeoB_N G-alpha ATP_bind_1 Septin NPR1_interact AAA_25
Other DBs
NCBI-GeneID: 108395842
NCBI-ProteinID: XP_017513921
LinkDB
Position
Unknown
AA seq 188 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKK
SKTKCIIM
NT seq 567 nt   +upstreamnt  +downstreamnt
atgactgaatataagcttgtggtagttggagctggtggcgttggcaagagtgccttgacg
atacagctaattcagaaccactttgtggatgaatatgatcctacgatagaggattcctac
aggaaacaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctatgt
gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaata
aaaagagttaaagactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg
ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttacggaattcct
tttattgaaacatcagcaaagacaagacagggtgtcgatgatgctttctatacattagtt
cgagaaattcgaaaacataaagaaaagatgagcaaagatggtaaaaagaagaaaaagaag
tcaaagacaaagtgtataattatgtaa

KEGG   Manis javanica (Malayan pangolin): 108398047
Entry
108398047         CDS       T06054                                 

Gene name
NRAS
Definition
(RefSeq) GTPase NRas
  KO
K07828  GTPase NRas
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv01522  Endocrine resistance
mjv04010  MAPK signaling pathway
mjv04012  ErbB signaling pathway
mjv04014  Ras signaling pathway
mjv04015  Rap1 signaling pathway
mjv04062  Chemokine signaling pathway
mjv04068  FoxO signaling pathway
mjv04071  Sphingolipid signaling pathway
mjv04072  Phospholipase D signaling pathway
mjv04137  Mitophagy - animal
mjv04140  Autophagy - animal
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
mjv04211  Longevity regulating pathway
mjv04213  Longevity regulating pathway - multiple species
mjv04218  Cellular senescence
mjv04360  Axon guidance
mjv04370  VEGF signaling pathway
mjv04371  Apelin signaling pathway
mjv04540  Gap junction
mjv04550  Signaling pathways regulating pluripotency of stem cells
mjv04625  C-type lectin receptor signaling pathway
mjv04650  Natural killer cell mediated cytotoxicity
mjv04660  T cell receptor signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04714  Thermogenesis
mjv04720  Long-term potentiation
mjv04722  Neurotrophin signaling pathway
mjv04725  Cholinergic synapse
mjv04726  Serotonergic synapse
mjv04730  Long-term depression
mjv04810  Regulation of actin cytoskeleton
mjv04910  Insulin signaling pathway
mjv04912  GnRH signaling pathway
mjv04915  Estrogen signaling pathway
mjv04916  Melanogenesis
mjv04917  Prolactin signaling pathway
mjv04919  Thyroid hormone signaling pathway
mjv04921  Oxytocin signaling pathway
mjv04926  Relaxin signaling pathway
mjv04929  GnRH secretion
mjv04933  AGE-RAGE signaling pathway in diabetic complications
mjv04935  Growth hormone synthesis, secretion and action
mjv05010  Alzheimer disease
mjv05022  Pathways of neurodegeneration - multiple diseases
mjv05034  Alcoholism
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05163  Human cytomegalovirus infection
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05200  Pathways in cancer
mjv05203  Viral carcinogenesis
mjv05205  Proteoglycans in cancer
mjv05206  MicroRNAs in cancer
mjv05210  Colorectal cancer
mjv05211  Renal cell carcinoma
mjv05213  Endometrial cancer
mjv05214  Glioma
mjv05215  Prostate cancer
mjv05216  Thyroid cancer
mjv05218  Melanoma
mjv05219  Bladder cancer
mjv05220  Chronic myeloid leukemia
mjv05221  Acute myeloid leukemia
mjv05223  Non-small cell lung cancer
mjv05224  Breast cancer
mjv05225  Hepatocellular carcinoma
mjv05226  Gastric cancer
mjv05230  Central carbon metabolism in cancer
mjv05231  Choline metabolism in cancer
mjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108398047 (NRAS)
   04012 ErbB signaling pathway
    108398047 (NRAS)
   04014 Ras signaling pathway
    108398047 (NRAS)
   04015 Rap1 signaling pathway
    108398047 (NRAS)
   04370 VEGF signaling pathway
    108398047 (NRAS)
   04371 Apelin signaling pathway
    108398047 (NRAS)
   04068 FoxO signaling pathway
    108398047 (NRAS)
   04072 Phospholipase D signaling pathway
    108398047 (NRAS)
   04071 Sphingolipid signaling pathway
    108398047 (NRAS)
   04151 PI3K-Akt signaling pathway
    108398047 (NRAS)
   04150 mTOR signaling pathway
    108398047 (NRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108398047 (NRAS)
   04137 Mitophagy - animal
    108398047 (NRAS)
  09143 Cell growth and death
   04210 Apoptosis
    108398047 (NRAS)
   04218 Cellular senescence
    108398047 (NRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    108398047 (NRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    108398047 (NRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108398047 (NRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    108398047 (NRAS)
   04650 Natural killer cell mediated cytotoxicity
    108398047 (NRAS)
   04660 T cell receptor signaling pathway
    108398047 (NRAS)
   04662 B cell receptor signaling pathway
    108398047 (NRAS)
   04664 Fc epsilon RI signaling pathway
    108398047 (NRAS)
   04062 Chemokine signaling pathway
    108398047 (NRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108398047 (NRAS)
   04929 GnRH secretion
    108398047 (NRAS)
   04912 GnRH signaling pathway
    108398047 (NRAS)
   04915 Estrogen signaling pathway
    108398047 (NRAS)
   04917 Prolactin signaling pathway
    108398047 (NRAS)
   04921 Oxytocin signaling pathway
    108398047 (NRAS)
   04926 Relaxin signaling pathway
    108398047 (NRAS)
   04935 Growth hormone synthesis, secretion and action
    108398047 (NRAS)
   04919 Thyroid hormone signaling pathway
    108398047 (NRAS)
   04916 Melanogenesis
    108398047 (NRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    108398047 (NRAS)
   04726 Serotonergic synapse
    108398047 (NRAS)
   04720 Long-term potentiation
    108398047 (NRAS)
   04730 Long-term depression
    108398047 (NRAS)
   04722 Neurotrophin signaling pathway
    108398047 (NRAS)
  09158 Development and regeneration
   04360 Axon guidance
    108398047 (NRAS)
  09149 Aging
   04211 Longevity regulating pathway
    108398047 (NRAS)
   04213 Longevity regulating pathway - multiple species
    108398047 (NRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    108398047 (NRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108398047 (NRAS)
   05206 MicroRNAs in cancer
    108398047 (NRAS)
   05205 Proteoglycans in cancer
    108398047 (NRAS)
   05203 Viral carcinogenesis
    108398047 (NRAS)
   05230 Central carbon metabolism in cancer
    108398047 (NRAS)
   05231 Choline metabolism in cancer
    108398047 (NRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108398047 (NRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108398047 (NRAS)
   05225 Hepatocellular carcinoma
    108398047 (NRAS)
   05226 Gastric cancer
    108398047 (NRAS)
   05214 Glioma
    108398047 (NRAS)
   05216 Thyroid cancer
    108398047 (NRAS)
   05221 Acute myeloid leukemia
    108398047 (NRAS)
   05220 Chronic myeloid leukemia
    108398047 (NRAS)
   05218 Melanoma
    108398047 (NRAS)
   05211 Renal cell carcinoma
    108398047 (NRAS)
   05219 Bladder cancer
    108398047 (NRAS)
   05215 Prostate cancer
    108398047 (NRAS)
   05213 Endometrial cancer
    108398047 (NRAS)
   05224 Breast cancer
    108398047 (NRAS)
   05223 Non-small cell lung cancer
    108398047 (NRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108398047 (NRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    108398047 (NRAS)
  09165 Substance dependence
   05034 Alcoholism
    108398047 (NRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    108398047 (NRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108398047 (NRAS)
   05170 Human immunodeficiency virus 1 infection
    108398047 (NRAS)
   05161 Hepatitis B
    108398047 (NRAS)
   05160 Hepatitis C
    108398047 (NRAS)
   05163 Human cytomegalovirus infection
    108398047 (NRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108398047 (NRAS)
   05165 Human papillomavirus infection
    108398047 (NRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108398047 (NRAS)
   01522 Endocrine resistance
    108398047 (NRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mjv04131]
    108398047 (NRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mjv04147]
    108398047 (NRAS)
   04031 GTP-binding proteins [BR:mjv04031]
    108398047 (NRAS)
Membrane trafficking [BR:mjv04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    108398047 (NRAS)
Exosome [BR:mjv04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   108398047 (NRAS)
  Exosomal proteins of other body fluids (saliva and urine)
   108398047 (NRAS)
  Exosomal proteins of breast cancer cells
   108398047 (NRAS)
  Exosomal proteins of colorectal cancer cells
   108398047 (NRAS)
GTP-binding proteins [BR:mjv04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    108398047 (NRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Septin ParA Ldh_1_N
Other DBs
NCBI-GeneID: 108398047
NCBI-ProteinID: XP_017517293
LinkDB
Position
Unknown
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM
NT seq 570 nt   +upstreamnt  +downstreamnt
atgactgagtacaaactggtggtggttggagcaggtggtgttggaaaaagcgcactgaca
atccagctaatccagaaccactttgtagatgaatatgatcccaccatagaggattcttac
cgaaaacaggtcgttatagatggtgaaacctgtctgttggacatactggatacagctgga
caagaggagtacagtgccatgagagaccaatacatgaggacaggcgaaggcttcctctgt
gtatttgccatcaataatagcaaatcatttgcagatattaacctttacagggaacagatt
aaacgagtaaaagattcagatgatgtacctatggtgctagtaggaaacaagtgtgatttg
ccaacaaggacagttgacacaaaacaagcccatgaactggccaagagttatgggattccg
ttcattgaaacctcagccaagacgagacagggtgttgaagatgccttttacacactggta
agagaaatccgtcagtatcgaatgaagaaactcaacagcagtgatgatgggactcaaggt
tgtatggggttgccatgtgtggtgatgtaa

KEGG   Manis javanica (Malayan pangolin): 108408627
Entry
108408627         CDS       T06054                                 

Gene name
HRAS
Definition
(RefSeq) GTPase HRas isoform X1
  KO
K02833  GTPase HRas
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv01522  Endocrine resistance
mjv04010  MAPK signaling pathway
mjv04012  ErbB signaling pathway
mjv04014  Ras signaling pathway
mjv04015  Rap1 signaling pathway
mjv04062  Chemokine signaling pathway
mjv04068  FoxO signaling pathway
mjv04071  Sphingolipid signaling pathway
mjv04072  Phospholipase D signaling pathway
mjv04137  Mitophagy - animal
mjv04140  Autophagy - animal
mjv04144  Endocytosis
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
mjv04211  Longevity regulating pathway
mjv04213  Longevity regulating pathway - multiple species
mjv04218  Cellular senescence
mjv04360  Axon guidance
mjv04370  VEGF signaling pathway
mjv04371  Apelin signaling pathway
mjv04510  Focal adhesion
mjv04540  Gap junction
mjv04550  Signaling pathways regulating pluripotency of stem cells
mjv04625  C-type lectin receptor signaling pathway
mjv04630  JAK-STAT signaling pathway
mjv04650  Natural killer cell mediated cytotoxicity
mjv04660  T cell receptor signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04714  Thermogenesis
mjv04720  Long-term potentiation
mjv04722  Neurotrophin signaling pathway
mjv04725  Cholinergic synapse
mjv04726  Serotonergic synapse
mjv04730  Long-term depression
mjv04810  Regulation of actin cytoskeleton
mjv04910  Insulin signaling pathway
mjv04912  GnRH signaling pathway
mjv04915  Estrogen signaling pathway
mjv04916  Melanogenesis
mjv04917  Prolactin signaling pathway
mjv04919  Thyroid hormone signaling pathway
mjv04921  Oxytocin signaling pathway
mjv04926  Relaxin signaling pathway
mjv04929  GnRH secretion
mjv04933  AGE-RAGE signaling pathway in diabetic complications
mjv04935  Growth hormone synthesis, secretion and action
mjv05010  Alzheimer disease
mjv05022  Pathways of neurodegeneration - multiple diseases
mjv05034  Alcoholism
mjv05132  Salmonella infection
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05163  Human cytomegalovirus infection
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05200  Pathways in cancer
mjv05203  Viral carcinogenesis
mjv05205  Proteoglycans in cancer
mjv05206  MicroRNAs in cancer
mjv05210  Colorectal cancer
mjv05211  Renal cell carcinoma
mjv05213  Endometrial cancer
mjv05214  Glioma
mjv05215  Prostate cancer
mjv05216  Thyroid cancer
mjv05218  Melanoma
mjv05219  Bladder cancer
mjv05220  Chronic myeloid leukemia
mjv05221  Acute myeloid leukemia
mjv05223  Non-small cell lung cancer
mjv05224  Breast cancer
mjv05225  Hepatocellular carcinoma
mjv05226  Gastric cancer
mjv05230  Central carbon metabolism in cancer
mjv05231  Choline metabolism in cancer
mjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108408627 (HRAS)
   04012 ErbB signaling pathway
    108408627 (HRAS)
   04014 Ras signaling pathway
    108408627 (HRAS)
   04015 Rap1 signaling pathway
    108408627 (HRAS)
   04370 VEGF signaling pathway
    108408627 (HRAS)
   04371 Apelin signaling pathway
    108408627 (HRAS)
   04630 JAK-STAT signaling pathway
    108408627 (HRAS)
   04068 FoxO signaling pathway
    108408627 (HRAS)
   04072 Phospholipase D signaling pathway
    108408627 (HRAS)
   04071 Sphingolipid signaling pathway
    108408627 (HRAS)
   04151 PI3K-Akt signaling pathway
    108408627 (HRAS)
   04150 mTOR signaling pathway
    108408627 (HRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    108408627 (HRAS)
   04140 Autophagy - animal
    108408627 (HRAS)
   04137 Mitophagy - animal
    108408627 (HRAS)
  09143 Cell growth and death
   04210 Apoptosis
    108408627 (HRAS)
   04218 Cellular senescence
    108408627 (HRAS)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108408627 (HRAS)
   04540 Gap junction
    108408627 (HRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    108408627 (HRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108408627 (HRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    108408627 (HRAS)
   04650 Natural killer cell mediated cytotoxicity
    108408627 (HRAS)
   04660 T cell receptor signaling pathway
    108408627 (HRAS)
   04662 B cell receptor signaling pathway
    108408627 (HRAS)
   04664 Fc epsilon RI signaling pathway
    108408627 (HRAS)
   04062 Chemokine signaling pathway
    108408627 (HRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108408627 (HRAS)
   04929 GnRH secretion
    108408627 (HRAS)
   04912 GnRH signaling pathway
    108408627 (HRAS)
   04915 Estrogen signaling pathway
    108408627 (HRAS)
   04917 Prolactin signaling pathway
    108408627 (HRAS)
   04921 Oxytocin signaling pathway
    108408627 (HRAS)
   04926 Relaxin signaling pathway
    108408627 (HRAS)
   04935 Growth hormone synthesis, secretion and action
    108408627 (HRAS)
   04919 Thyroid hormone signaling pathway
    108408627 (HRAS)
   04916 Melanogenesis
    108408627 (HRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    108408627 (HRAS)
   04726 Serotonergic synapse
    108408627 (HRAS)
   04720 Long-term potentiation
    108408627 (HRAS)
   04730 Long-term depression
    108408627 (HRAS)
   04722 Neurotrophin signaling pathway
    108408627 (HRAS)
  09158 Development and regeneration
   04360 Axon guidance
    108408627 (HRAS)
  09149 Aging
   04211 Longevity regulating pathway
    108408627 (HRAS)
   04213 Longevity regulating pathway - multiple species
    108408627 (HRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    108408627 (HRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108408627 (HRAS)
   05206 MicroRNAs in cancer
    108408627 (HRAS)
   05205 Proteoglycans in cancer
    108408627 (HRAS)
   05203 Viral carcinogenesis
    108408627 (HRAS)
   05230 Central carbon metabolism in cancer
    108408627 (HRAS)
   05231 Choline metabolism in cancer
    108408627 (HRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108408627 (HRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108408627 (HRAS)
   05225 Hepatocellular carcinoma
    108408627 (HRAS)
   05226 Gastric cancer
    108408627 (HRAS)
   05214 Glioma
    108408627 (HRAS)
   05216 Thyroid cancer
    108408627 (HRAS)
   05221 Acute myeloid leukemia
    108408627 (HRAS)
   05220 Chronic myeloid leukemia
    108408627 (HRAS)
   05218 Melanoma
    108408627 (HRAS)
   05211 Renal cell carcinoma
    108408627 (HRAS)
   05219 Bladder cancer
    108408627 (HRAS)
   05215 Prostate cancer
    108408627 (HRAS)
   05213 Endometrial cancer
    108408627 (HRAS)
   05224 Breast cancer
    108408627 (HRAS)
   05223 Non-small cell lung cancer
    108408627 (HRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108408627 (HRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    108408627 (HRAS)
  09165 Substance dependence
   05034 Alcoholism
    108408627 (HRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    108408627 (HRAS)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108408627 (HRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108408627 (HRAS)
   05170 Human immunodeficiency virus 1 infection
    108408627 (HRAS)
   05161 Hepatitis B
    108408627 (HRAS)
   05160 Hepatitis C
    108408627 (HRAS)
   05163 Human cytomegalovirus infection
    108408627 (HRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108408627 (HRAS)
   05165 Human papillomavirus infection
    108408627 (HRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108408627 (HRAS)
   01522 Endocrine resistance
    108408627 (HRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mjv04131]
    108408627 (HRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mjv04147]
    108408627 (HRAS)
   04031 GTP-binding proteins [BR:mjv04031]
    108408627 (HRAS)
Membrane trafficking [BR:mjv04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    108408627 (HRAS)
Exosome [BR:mjv04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   108408627 (HRAS)
  Exosomal proteins of colorectal cancer cells
   108408627 (HRAS)
GTP-binding proteins [BR:mjv04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    108408627 (HRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Gtr1_RagA G-alpha ATP_bind_1 Septin Ldh_1_N AAA_25 AAA_16
Other DBs
NCBI-GeneID: 108408627
NCBI-ProteinID: XP_017534296
LinkDB
Position
Unknown
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKARKLSPPDEGGPG
CMSCKCLLS
NT seq 570 nt   +upstreamnt  +downstreamnt
atgacggaatataagctggtggtggtgggcgctgggggcgtggggaagagtgccctgacc
atccagctcatccagaaccacttcgtggacgagtatgaccccaccatcgaggattcctac
cggaagcaagtggtcattgatggggagacgtgtctgctagacatcctggacacggcgggc
caggaggagtacagcgccatgcgggaccagtacatgcgtactggggagggcttcctctgt
gtgttcgccatcaacaacaccaaatcttttgaggacatccaccaatacagggagcagatc
aagcgagtgaaggactcagacgatgtgcccatggtcctagtcgggaacaagtgtgacctg
gctgcacgcactgtggagtctcggcaggcacaggaccttgcccgaagctatggcatcccc
tacatagagacatcggccaagacgcgccagggcgtggaggatgccttctacaccctggtg
cgtgagatccggcagcacaaggcgcgcaaactgagcccgccggacgagggcggcccgggc
tgcatgagctgcaagtgcctgctctcctga

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